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All Journal Jurnal Radioisotop dan Radiofarmaka Pharmaciana: Jurnal Kefarmasian
Anung Pujiyanto
Pusat Radioisotop dan Radiofarmaka-BATAN
Medicine & Pharmacology

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Clearance profile of radioactive gold nanoparticle (198Au) conjugates-poliamidoamin generation 4-nimotuzumab ; potential radio-pharmaceutical theranostic agent Halid, Nurhatidjah Awaliyah; Mutalib, Abdul; Pujiyanto, Anung; Gunawan, Adang Hardi
Pharmaciana Vol 7, No 2 (2017): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (581.999 KB) | DOI: 10.12928/pharmaciana.v7i2.6725

Abstract

Theranostic agents are agents that combine diagnostic and therapeutic capabilities into a single agent. The presence of conjugated cancer which is therapeutic agents such as nimotuzumab monoclonal antibodies with radioactive gold nanoparticles stabilized with Polyamidoamine Generation 4 (PAMAM G4) dendrimer can actively interact with specific cancer cells. Radioactive gold (198Au) as a radiation transmitter β (961 keV) capable for killing cancer cells and (412 keV) γ rays that give a golden image in the body, thus acting as a theranostic agent. The purpose of this study was to obtain confident results of conjugate safety by observing the constituent clearance of 198AuNP-PAMAM G4-Nimotuzumab. The result of the conjugate clearance will be the reference for the metabolic state as a new, stable and complete radiofarmaka upon reaching the desired target. This study began with the synthesis of the conjugate of 198AuNp-PAMAM G4-nimotuzumab and then tested the clirens and analyzed the results of urine and mouse feces that had been injected with conjugate. Total clearance was obtained about 47.38% of the 198AuNP-PAMAM G4-Nimotuzumab conjugates that have been excreted through urine (18.26%) and stool (29.11%.). Urine and feces were analyzed with SDS-PAGE giving the spot above the 150 kDa band and showing the conjugate molecular weight. FTIR analysis of urine and feces by showing aldehyde functional groups (C = O), alcoholic groups (O-H), amine groups (C-N), and amine groups (N-H) indicating the presence of AuNP-PAMAM G4-Nimotuzumab conjugates in urine and mouse feces. The results of urine and fecal excretion of the conjugate are still conjugate-shaped supported by SDS PAGE analysis, UV-Vis spectrophotometer absorption analysis and functional group analysis with FTIR that has been conducted.
PEMISAHAN Mn-54 DARI HASIL IRADIASI Fe2O3 ALAM MENGGUNAKAN RESIN PENUKAR ANION Pujiyanto, Anung; Hambali, .; Kurniasih, Dede; Endang, .; Mujinah, .
Jurnal Radioisotop dan Radiofarmaka Vol 8 (2005): JURNAL PRR 2005
Publisher : Jurnal Radioisotop dan Radiofarmaka

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (115.108 KB)

Abstract

PEMISAHAN Mn-54 DARI HASIL IRADIASI Fe2O3ALAM MENGGUNAKAN RESIN PENUKAR ANION. Pembuatan radioisotop dari iradiasi target alam mempunyai keuntungan yaitu biaya produksi lebih murah, namun radioisotop yang dihasilkan mungkin mengandung radionuklida pengotor. Pembuatan Mn-54 dari iradiasi Fe2O3 alam mempunyai masalah yaitu dihasilkan juga radioisotop Fe-59. Pemisahan Mn-54 dari iradiasi Fe2O3 alam dapat dilakukan dengan melarutkan Fe2O3 alam dengan HCl kemudian hasil pelarutan dipisahkan dengan dowex 1x 8Cl- form. Telah dilakukan proses pemisahan Mn-54 dari Fe2O3 alam yang telah diiradiasi, dengan cara melarutkan Fe2O3 alam dengan HCl kemudian hasil pelarutan dipisahkan dengan dowex 1x 8Cl- form dengan variasi waktu kontak dan kosentrasi HCl yang berbeda. Hasil pemisahan Mn-54 dari hasil iradiasi Fe2O3 menunjukkan pada konsentrasi HCl 8 N dan waktu kontak 90 menit memberikan efisiensi pemisahan yang baik yaitu 7,55 % untuk Mn-54 dan 94,13% untuk Fe-59. Kata kunci:Pemisahan, Mn-54, resin penukar anion SEPARATION of Mn-54 FROM IRRADIATED NATURAL Fe2O3 USING ANION EXCHANGE RESIN. Preparation of radiosisotope from natural target has an advantage namely the production is cheaper, but the produced radioisotope may content radionuclidic impurities. Preparation of Mn-54 from irradiated natural Fe2O3 has a problem due to Fe-59 impurity . The separation of Mn-54 from irradiated natural Fe2O3 has been carried out by means of solving irradiated target using HCl and dowex resin 1 x 8 Cl form. The separation of Mn-54 from iradiated natural Fe2O3 showed a good result by 8 N HCl concentration and 90 minute contact time and efficiency was 7,55 % Mn-54 and 94,13 % for Fe-59. Key words: Separation, Mn-54 , anion exchange resin
Co-Authors . Endang . Hambali . Mujinah Adang Hardi Gunawan Dede Kurniasih Mutalib, Abdul Nur Hatidjah Awaliyah Halid