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All Journal Acta Chimica Asiana Sasambo Journal of Pharmacy
Rizqa Fersiyana Deccati
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Chemistry Health Professions Medicine & Pharmacology

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Aktivitas antioksidan ekstrak etanol daun pecut kuda (Stachytarpheta jamaicensis (L.) Vahl) menggunakan metode ekstraksi berbasis gelombang ultrasonic Rian Jumawardi; Agus Dwi Ananto; Rizqa Fersiyana Deccati
Sasambo Journal of Pharmacy Vol. 2 No. 2 (2021): September
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (262.456 KB) | DOI: 10.29303/sjp.v2i2.85

Abstract

 Free radical is an atom or molecule that has unpaired electrons, is reactive and unstable which can cause damage to cells and tissues. Secondary metabolite compounds in plants such as phenolics, flavonoids, tannins, and saponins can inhibit free radicals. One of the plants that has the potential as an antioxidant is a Stachytarpheta jamaicensis (L.) Vahl. The part of the plant that is often used as a medicinal ingredient by Indonesian people is the leaf part. The leaves of snakeweed are natural ingredients that are rich in phenolic compounds, flavonoids, tannins, and saponins. This study aims to determine the activity of free radical inhibition in the snakeweed leaf extract with Ultrasound Assisted Extraction method. Determination of free radical inhibition activity was examined using DPPH method at the concentration series of snakeweed leaf extracts of 60, 65, 70, 75, 80, and 85 ppm. The comparison solution used was vitamin C made with a concentration series of 4, 5, 6, 7, 9, and 11 ppm. The results showed that vitamin C had a free radical inhibitory activity with an IC50 value of 9.40 ± 0.07 ppm, while the extract of snakeweed leaf had free radical inhibition activity with an IC50 value of 74.32 ± 0.71 ppm. Based on the IC50 value, the intensity of free radical inhibition activity in vitamin C is classified as very strong and the extract of snakeweed leaf is strong
Penentuan Kadar Flavonoid Total dalam Ekstrak Etanol Buah Renggak (Amomum dealbatum Roxb.) Menggunakan Spektrofotometri UV–Vis Lalu Ardian Hadi; Rizqa Fersiyana Deccati; Handa Muliasari; Nisa Isneni Hanifa
Acta Chimica Asiana Vol. 9 No. 1 (2026)
Publisher : The Indonesian Chemical Society, Chapter Nusa Tenggara and The University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/aca.v9i1.278

Abstract

The local plant, Amomum dealbatum Roxb. (A. dealbatum), is native to Lombok Island. This plant is a member of the Zingiberaceae family, which is recognised to have antifungal and antibacterial properties due to the presence of secondary metabolites, particularly flavonoids. Nevertheless, there is still little information and few reports regarding the overall flavonoid content of A. dealbatum fruit. As a chemical marker to support an extract’s quality control and pharmacological effects, Total Flavonoid Content (TFC) determination is crucial. The purpose of this work was to use UV-Vis spectrophotometry to measure the TFC in the ethanol extract of A. dealbatum fruit. Using a 1:10 solvent: simplicia ratio and maceration with 96% ethanol, the extraction procedure was completed. Thin Layer Chromatography (TLC) and the Wilstatter test were then used to identify the extracted material qualitatively. Using a UV-Vis spectrophotometer and a colourimetric approach, TFC was measured. The ethanol extract of A. dealbatum fruit contained flavonoids, as indicated by the qualitative analysis. The TFC values were 3.0833 ± 0.1439 mg rutin equivalent (RE)/g extract and 0.4858 ± 0.0014 mg quercetin equivalent (QE)/g extract. These findings suggest that the ethanol extract of A. dealbatum contains more flavonoid glycosides than flavonoid aglycones. This finding shows potential for further development. As this study is still limited to TFC at the extract level, further research on TFC at the fraction, sub-fraction, and isolate levels is needed to obtain more specific information about the active compounds contributing to its biological activities. In addition, further pharmacological testing is required to confirm the therapeutic potential of A. dealbatum and support its development as a candidate raw material for traditional medicine industries.
Co-Authors Agus Dwi Ananto, Agus Handa Muliasari Lalu Ardian Hadi Nisa Isneni Hanifa Rian Jumawardi