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Tonny .
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience

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PENERIMA ASAM RETINOID a (a RETINOID ACID RECEPTOR) DI LEUKEMIA AKUT PROMYELOSITIK DENGAN BATANGAN (ROD) AUER Adi K Aman; Tonny .
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 15, No 3 (2009)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v15i3.966

Abstract

Acute Promyelocytic Leukemia (APL) is a subtype of AML with a defined clinical course and biology that is distinct from otherforms of AML. The term M3-AML was assigned to the hyper granular promyelocytic leukaemia that is characterized by blast cells withazurophilic granules, bundles of auer rods and reniform or bilobed nucleus. Clinically, APL is related to disseminate intravascularcoagulation and abnormal fibrinolysis. Cytogenetically, APL may cause translocation on the promyelocytic leukaemia (PML) gene,and chromosome 15 and with the retinoic acid receptor α (RARA) gene, on chromosome 17. The diagnosis of APL is shown by bonemarrow morphologically The majority of cells in the bone marrow are abnormal, having some similarities with promyelocytes. Themalignant cells bear numerous large granules and several auer rods. Aspirates of bone marrow are also taken for cytogenesis evaluationand for detecting the translocation. A twelve years girl was admitted to the hospital with haemorrhage from the gums during 5 dayafter extraction of a tooth. On physical examination there is no organomegaly shown. The laboratory examination found normocyticnormochromic anaemia, leucopoenia and thrombocytopenia with 15% blast cell and 5% promyelocytes with multiple auer rods. Thebone marrow aspirates showed predominant of promyelocyte cells (70%) with multiple auer rods.
PEMERIKSAAN CD4 HUBUNGANNYA DENGAN STADIUM PENYAKIT HIV PENDERITA Adi K. Aman; Tonny .; Rachmad .
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 14, No 3 (2008)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v14i3.926

Abstract

The accurate measuring CD4 are important for knowing immune system from HIV infected person. Because there are increasing clinical complication with decreasing of CD4. Measuring of CD4 also useful for the decisions when therapy of ART started and monitoringefficacy of the medication. Also it is necessary to know CD4 and its relations to HIV stadium in HIV positive patients at Adam MalikGeneral Hospital Medan. The CD4 examination used in EDTA blood. Immunophenotyping examination carried out by Flow CytometryBD FACS CaliburTM used TritestTM BD reagent CD3/CD4/CD45 without true count tube. From 515 HIV patients, 80.5% are men, 86%from all patients between 20-40 years old with biggest risk factor are heterosexual. From 250 patients that examination of CD4, 81%patients are stadium I had amount CD4 > 350/mm. Examination of CD4 arethe important parameter to follow up condition of HIV patient for prevented not become worse, also knowing diseases progressivismand therapy progress.3 and patients stadium III had amount CD4 < 200/mm3
Co-Authors Adi K Aman Adi K. Aman Rachmad .