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All Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Uleng Bahrun
Department of Clinical Pathology, Faculty of Medicine, Hasanuddin University, Makassar
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience

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RELATIONSHIP BETWEEN NEUTROPHIL - LYMPHOCYTE RATIO AND DECREASED GLOMERULAR FILTRATION RATE IN DIABETIC NEPHROPATHY Asriyani Azikin; Fitriani Mangarengi; Uleng Bahrun
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 24, No 2 (2018)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v24i2.1311

Abstract

Diabetic nephropathy is one of the fairly severe Diabetes Mellitus (DM) complications and the main cause of renal failure that can result in mortality. Hyperglycemia in DM induces kidney injury that may result in hemodynamic and metabolic alterations, endothelial dysfunction and inflammatory cells activation. A persistent and continuous inflammation is observed in diabetic nephropathy. One of the inflammation process progression indicators is Neutrophil-Lymphocyte Ratio (NLR). To find out the relationship between NLR and decreased Glomerular Filtration Rate (GFR) in diabetic nephropathy. This study was an observational study with a retrospective approach. This study was conducted in Clinical Pathology Laboratory Installation and Medical Record Installation of Dr. Wahidin Sudirohusodo Makassar Hospital by collecting the patient’s data during February 2015 to February 2016. Patients that were diagnosed as type 2 DM without diabetic nephropathy complication were taken as control and those diagnosed as type 2 DM with diabetic nephropathy were treated as study subjects. One hundred and thirteen (113) samples met the inclusion criteria, consisting of 73 diabetic nephropathy patients with Chronic Kidney Disease (CKD) 13 diabetic nephropathy patients without CKD and 27 type 2 DM patients without diabetic nephropathy complication. Patients consisted of 57 males (50.4%) and 56 females (49,6%). Neutrophil-lymphocyte ratio and GFR values in the group of diabetic nephropathy without CKD were 2.03±0.68 and 85.38±24.63, respectively. Whereas, the NLR and GFR values in control group were 1.74±0.54 and 90.03±28.60, respectively. In the group of diabetic nephropathy with CKD, NLR value increased by 3.19±1.83 and GFR decrease by 30.54±16.45. Spearman test indicated a significant relationship between NLR increase and decreased GFR (r = -0.635, p=0.00). There is a significant relationship between  NLR increase and decreased GFR in patients with diabetic nephropathy. 
A Literature Review: Relationship between Interleukin-1 Beta and the Severity of COVID-19 Andi Ita Maghfirah; Tenri Esa; Uleng Bahrun
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 30 No. 3 (2024)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v30i3.2255

Abstract

COVID-19 disease can cause dysregulation of the immune system, resulting in a cytokine storm. One of the cytokines released is IL-1B, a proinflammatory cytokine due to macrophage stimulation. This study aimed to provide a literature review of the value of Interleukin-1 beta (IL-1B) in patients with severity of COVID-19. This literature review was carried out using the search engines PubMed, Open Accessed Journal, Science Direct, and Google Scholar from December 2019 to December 2022. No studies suggested that IL-1B was associated with the severity of COVID-19. IL-1B is vital during the acute inflammatory response and helps T cells by linking innate and adaptive immunity as a lymphocyte activation factor. A gradual decrease in lymphocyte count was reported in severe COVID-19 diseases. The substantial reduction in lymphocyte count indicates that the SARS-CoV-2 virus increases immune cells and inhibits cellular immunity. This result might explain why IL-1B levels in mild COVID-19 were not significantly different from IL-1B levels in severe COVID-19. There was an increase in IL-1B levels in COVID-19 patients, but there was no relationship between IL-1B and the severity of COVID-19.
Co-Authors Andi Ita Maghfirah Asriyani Azikin Fitriani Mangarengi Tenri Esa