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All Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Elisabeth Setianingrum
Nusa Cendana University
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience

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THE DIFFERENCE BETWEEN NEUTROFIL TOTAL, NEUTROPHIL / LYMPHOCYTE AND PLATELETS / LYMPHOCYTE RATIO IN NORMAL PATIENTS, NSTEMI, STEMI Elisabeth Setianingrum; Purwanto A P
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 25, No 3 (2019)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v25i3.1445

Abstract

Sindrom Koroner Akut(SKA) yaitu Non ST Elevasi Miokard Infark (NSTEMI) dan ST Elevasi Miokard Infark (STEMI) disebabkan oleh aterosklerosis pembuluh darah, merupakan proses inflamasi akut diawali kerusakan endotel. Neutrofil Absolut (NA), Neutrofil/Limfosit Ratio (NLR), Platelet/ Limfosit Ratio (PLR) merupakan petanda inflamasi sistemik pada penyakit inflamasi. Tujuan untuk membandingkan NA, NLR dan PLR sebagai petanda inflamasi pada pasien normal, NSTEMI dan STEMI . Penelitian observasional analitik dengan pendekatan belah lintang terhadap 101 pasien SKA di RSU Negeri yang terbagi menjadi 3 kelompok (normal, NSTEMI, STEMI). Leukosit, platelet dihitung dengan hematology analizer, limfosit dan neutrofil dengan hitung jenis . Analisis data menggunakan uji Kruskal Wallis  dilanjutkan uji post hoc Mann-Whitney. Terdapat perbedaan NA,NLR pasien normal dengan NSTEMI dan pasien normal dengan STEMI (p=0,000). Tidak terdapat perbedaan PLR pada pasien normal dan NSTEMI, pasien normal dan STEMI, NSTEMI dan STEMI. Neutrofil Absolut dan Neutrofil/Limfosit Ratio sebagai faktor independent yang baik untuk petanda inflamasi sistemik menggambarkan prognosis penyakit.
THE DIFFERENCE BETWEEN NEUTROFIL TOTAL, NEUTROPHIL / LYMPHOCYTE AND PLATELETS / LYMPHOCYTE RATIO IN NORMAL PATIENTS, NSTEMI, STEMI Elisabeth Setianingrum; Purwanto A P
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 25 No. 3 (2019)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v25i3.1445

Abstract

  Acute Coronary Syndrome (ACS) is a Non-ST-Elevation Myocardial Infarct (NSTEMI) and ST-Elevation Myocardial Infarct (STEMI) caused by atherosclerosis vascular, endothelial dysfunction as an acute inflammatory response. Absolute Neutrophils (AN), Neutrophil/Lymphocyte Ratio (NLR), and Platelet/Lymphocyte Ratio (PLR) is a systemic inflammation marker in inflammatory diseases. The research purpose was to compare AN, NLR, and PLR as an inflammatory marker in normal patients and, NSTEMI, STEMI. A cross-sectional observational study of 101 ACS patients at the Dr. Kariadi Hospital, divided into three groups (normal, NSTEMI, and STEMI). Neutrophil and lymphocyte were counted manually. Leukocyte and platelet value were determined by hematology analyzer. Data were analyzed with the Kruskal-Wallis test followed by post hoc Mann-Whitney. There was a difference in AN, NLR value between STEMI and NSTEMI compared to normal patients. There was no significant difference between PLR value.
Co-Authors Purwanto A P