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All Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Yuyun Widaningsih
Department of Clinical Pathology, Faculty of Medicine, Hasanuddin University/Dr. Wahidin Sudirohusodo, Makassar; Hasanuddin University Hospital, Makassar
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience

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Analysis of Platelet Indices and Proteinuria in Primary Hypertensive Patients Deny Suryana; Yuyun Widaningsih; Fitriani Mangarengi; Darwati Muhadi
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 28, No 2 (2022)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v28i2.1772

Abstract

Hypertension is a silent killer that causes premature death, an estimated 9.4 million people die each year due to hypertension and its complications. Primary hypertension promotes endothelial damage-causing platelet release reaction. Without treatment, it may cause renal damage, which leads to proteinuria. This study aimed to analyze the relationship of the platelet indices (PLT, PDW, PCT, MPV) in predicting proteinuria among patients with primary hypertension based on its stage. A retrospective study using medical records of patients diagnosed with primary hypertension by clinicians at Dr. Wahidin Sudirohusodo Hospital from January-December 2019. Complete Blood Count (CBC) using the flow cytometry and routine urine test with urine analyzer were performed. The statistical test used in this study were the independent T-test, Chi-Square test, and oneway ANOVA test. Receiver Operating Characteristics (ROC) were used to determine the cut-off. The sample consisted of 78 patients. Mean Platelet Volume (MPV) was significantly higher in proteinuria patients and stage two hypertension with p<0.001. There was a significant relationship between stage two hypertension and proteinuria with p=0.018. ROC analysis showed MPV Area Under the Curve (AUC) of 0.774 with p<0.001, which indicated that MPV can be used as a predictor of proteinuria with a cut-off point of 8.55. MPV increases on the platelet indices, proteinuria with stage 2 hypertension are caused by damage to glomerular endothelium, which leads to platelet activation characterized by degranulation, swelling, and increases in platelet mass and volume. There was a relationship between an increase of MPV and proteinuria in patients with stage 2 hypertension.
Analysis of Platelet Indices and Proteinuria in Primary Hypertensive Patients Deny Suryana; Yuyun Widaningsih; Fitriani Mangarengi; Darwati Muhadi
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 28 No. 2 (2022)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v28i2.1772

Abstract

Hypertension is a silent killer that causes premature death, an estimated 9.4 million people die each year due to hypertension and its complications. Primary hypertension promotes endothelial damage-causing platelet release reaction. Without treatment, it may cause renal damage, which leads to proteinuria. This study aimed to analyze the relationship of the platelet indices (PLT, PDW, PCT, MPV) in predicting proteinuria among patients with primary hypertension based on its stage. A retrospective study using medical records of patients diagnosed with primary hypertension by clinicians at Dr. Wahidin Sudirohusodo Hospital from January-December 2019. Complete Blood Count (CBC) using the flow cytometry and routine urine test with urine analyzer were performed. The statistical test used in this study were the independent T-test, Chi-Square test, and oneway ANOVA test. Receiver Operating Characteristics (ROC) were used to determine the cut-off. The sample consisted of 78 patients. Mean Platelet Volume (MPV) was significantly higher in proteinuria patients and stage two hypertension with p<0.001. There was a significant relationship between stage two hypertension and proteinuria with p=0.018. ROC analysis showed MPV Area Under the Curve (AUC) of 0.774 with p<0.001, which indicated that MPV can be used as a predictor of proteinuria with a cut-off point of 8.55. MPV increases on the platelet indices, proteinuria with stage 2 hypertension are caused by damage to glomerular endothelium, which leads to platelet activation characterized by degranulation, swelling, and increases in platelet mass and volume. There was a relationship between an increase of MPV and proteinuria in patients with stage 2 hypertension.
The Analysis of MPV, Plateletcrit, Platelet Distribution Width, and Total Platelets in AKI Ellen Kurniawati Tungka; Yuyun Widaningsih; Fitriani Mangarengi
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 29 No. 3 (2023)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v29i3.2012

Abstract

Patients with Acute Kidney Injury (AKI) who require hemodialysis had been reported to have a mortality rate of 50-70% in the last 30 years. Platelet and platelet index are two of the important hematological markers to be analyzed in AKI. This study aimed to analyze the levels of MPV, PCT, PDW, and total platelets in patients with AKI. A retrospective study using medical record data of 122 patients with AKI from January 2019 to December 2020 was conducted in Dr. Wahidin Sudirohusodo Hospital, Makassar. Patients were grouped based on disease outcomes and consisted of patients who died in the hospital and patients who recovered. Measurement of MPV, PCT, PDW, and platelet count was performed using a hematology analyzer. Mann-Whitney and independent T-tests were used for statistical analysis. The subjects of this study consisted of 80 AKI patients who died and 42 who recovered, the most affected age was > 56 years old. The mean MPV was significantly higher in subjects who died in the hospital (10.31±1.53 fL) than in patients who recovered (9.5±1.39 fL) (p<0.01). Mean PCT was higher in subjects who died in the hospital (0.85%) than in patients who recovered (0.18%), despite statistical insignificance (p>0.05). Mean PDW was higher in subjects who died in the hospital (14.2 fL) than in patients who recovered (13.2 fL), despite statistical insignificance (p>0.05). Mean platelet was lower in subjects who died in the hospital (174.3 x109L) than in patients who recovered (215.6 x109L), despite statistical insignificance (p>0.05). Mean platelet volume levels were elevated in AKI patients with poor outcomes, possibly associated with the pathogenesis of more severe inflammation caused by hyperaggregation and peripheral destruction of platelets, which provide positive feedback to the bone marrow to produce larger and more active platelets. The MPV levels were significantly higher in AKI patients with poor outcomes, whereas PCT, PDW, and total platelet levels were not significant.
Co-Authors Darwati Muhadi Deny Suryana Ellen Kurniawati Tungka Fitriani Mangarengi Fitriani Mangarengi