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All Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Siti Muchayat
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience

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CORRELATION BETWEEN MATRIX METALLOPROTEINASE 1 SERUM LEVELS AND MODEL OF END STAGE HEPATIC DISEASE SCORE IN PATIENTS WITH HEPATIC CIRRHOSIS Stephanus Yoanito; Siti Muchayat
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 23, No 3 (2017)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v23i3.1195

Abstract

Sirosis hati masih menjadi masalah kesehatan utama di dunia, merupakan penyakit fibrosis hati yang berkebahayaan komplikasi.Pemeriksaan biopsi hati masih merupakan baku emas dalam penegakan diagnosis sirosis hati, tetapi pemeriksaan ini bersifatmenyakitkan. Banyak model prognostik telah dikembangkan dalam dua dekade terakhir untuk meramalkan kematian di pasien sirosishati dan variabel yang termasuk dalam model ini adalah Model End Stage Hepatic Disease (MELD). Penelitian ini mengukur kadarMatrix Metalloproteinase 1 (MMP-1) serum sebagai enzim dalam proses degradasi matrix extraselular pada sirosis hati, yang dapatdigunakan untuk menilai tingkat keparahan di pasien sirosis hati. Tujuan penelitian ini adalah mengetahui korelasi kadar MMP-1 serumterhadap skor MELD di pasien sirosis hati. Penelitian ini menggunakan rancangan observasional potong lintang. Ciri subjek ditampilkansecara deskriptif dalam perbandingan. Ciri hasil laboratorium dalam bentuk rerata, simpang baku, median (minimum-maksimum).Uji Spearman digunakan untuk mengetahui kenasaban kadar MMP-1 serum terhadap skor MELD di pasien sirosis hati. Sebanyak 30pasien sirosis hati, rerata umur 52,43 tahun, dominasi laki-laki sebesar 19 pasien (63,3%), penyebab terbanyak adalah HBV sebesar18 pasien (60,4%), dengan nilai median skor MELD adalah 15,5 dan kadar rerata MMP-1 adalah 106,91 pg/mL. Terdapat kenasabannegatif moderate antara kadar MMP-1 serum dengan skor MELD dan bermakna dengan nilai r=- 0,402 (p=0,028). Terdapat kenasabannegatif moderate dan bermakna antara kadar MMP-1 serum dengan skor MELD di pasien sirosis hati. Untuk aplikasi klinis pemeriksaanMMP-1 serum dapat digunakan untuk memantau hasil pengobatan dan perjalanan penyakit pasien sirosis hati.
HIPERURISEMIA SEBAGAI FAKTOR RAMALAN PERJALANAN PENYAKIT (PROGNOSIS) GEJALA KLINIK STROK INFARK Fenty .; Harjo Mulyono; Siti Muchayat
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 16, No 3 (2010)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v16i3.1034

Abstract

Infarction stroke is a leading cause mortality and disability in the world. Appropriate management of acute infarction stroke will be able to reduced morbidity and mortality of the disease. Many laboratory parameters which can be done for detecting risk of prognosticfactors, one of them is serum uric acid concentration. The aim of this study is to know if hyperuricemia is prognostic factor for clinicaloutcome in acute infarction stroke.A prospective cohort study was carried out, compare between two groups of exposed and non-exposedgroup. Subjects who meet inclusion and exclusion criteria was involved in the study. The exposed group was a group of acute infarctionstroke patients who exposed to hyperuricemia, in other hand, patient who do not have hyperuricemia was separated as the non-exposedgroup. Inception cohort was applied when patient admits to emergency unit during 48 hours of onset, age ≥ 40 years old, man orwoman, have signed informed consent are inclusion criteria. Gadjah Mada Stroke Scale and serum uric acid concentration was measured on admission. Patient with haemorhage stroke and who are taking medicine that cause decrease uric acid are excluded. Test of serum uric acid concentration was performed by using Vitros 250, dry chemistry system. Patients were followed up 7 days in Neurology Unitand the outcome were measured by evaluating a score of Gadjah Mada Stroke Scale. Prognostic factor hyperuricemia has RR= 2.159(95% CI: 0.684-6.816), p= 0.158 for outcome. Hyperuricemia is not be evident as prognostic factor in acute infarction stroke.
Co-Authors Fenty . Harjo Mulyono Stephanus Yoanito