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All Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Darwati Muhadi
Department of Clinical Pathology, Faculty of Medicine, Hasanuddin University/Dr. Wahidin Sudirohusodo Central General Hospital, Makassar
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience

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Validity ICT and CLIA of SARS-CoV-2 Antibody Fili Oei; Asvin Nurulita; Darwati Muhadi; Mansyur Arif
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 28, No 2 (2022)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v28i2.1773

Abstract

The varying validity of antibody test requires a good diagnostic accuracy analysis in determining the right tome to perform antibody testing in patients. This study is to evaluate sensitivity and specificity of SARS-CoV2 antibody test based on the testing time. This stugy is a cross sectional retrospective diagnostic test study include 960 subject divided into 3 groups based on the testing time using 2 antibody test methods are ICT and CLIA. The sensitivity and specificity of ICT method was 45.8% and 59.7%, while the CLIA method was 81.6% and 74.4%. Based on timing of antibody test after symptom onset, the highest sensitivity was obtained at >15 days of symptom onset (84.4% and 78.7%). Low sensitivity can be caused due to the absence or low antibodies in the first week to second weeks of infection. Sample collection is done 2-4 weeks after symptom onset. The SARS CoV-2 IgM and IgG antibodies have high sensitivity and specificity at onset >15 days (84.4% and 78.7%).
Validity ICT and CLIA of SARS-CoV-2 Antibody Fili Oei; Asvin Nurulita; Darwati Muhadi; Mansyur Arif
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 28 No. 2 (2022)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v28i2.1773

Abstract

The varying validity of antibody test requires a good diagnostic accuracy analysis in determining the right tome to perform antibody testing in patients. This study is to evaluate sensitivity and specificity of SARS-CoV2 antibody test based on the testing time. This stugy is a cross sectional retrospective diagnostic test study include 960 subject divided into 3 groups based on the testing time using 2 antibody test methods are ICT and CLIA. The sensitivity and specificity of ICT method was 45.8% and 59.7%, while the CLIA method was 81.6% and 74.4%. Based on timing of antibody test after symptom onset, the highest sensitivity was obtained at >15 days of symptom onset (84.4% and 78.7%). Low sensitivity can be caused due to the absence or low antibodies in the first week to second weeks of infection. Sample collection is done 2-4 weeks after symptom onset. The SARS CoV-2 IgM and IgG antibodies have high sensitivity and specificity at onset >15 days (84.4% and 78.7%).
Co-Authors Asvin Nurulita Fili Oei Mansyur Arif