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All Journal Indonesian Journal of Cancer JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Indonesian Journal of Cancer
WITA SARASWATI, WITA
Department Of Obstetric And Gynecology, Airlangga University, Dr. Soetomo Hospital
Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Other

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Profil Sel Natural Killer (NK) dalam Darah Perifer dan Jaringan Tumor Penderita Lesi Prakanker dan Karsinoma Sel Skuamosa Serviks SARASWATI, WITA
Indonesian Journal of Cancer Vol 8, No 4 (2014): Oct - Dec 2014
Publisher : "Dharmais" Cancer Center Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (3091.165 KB)

Abstract

This research was performed to investigate the profile of Natural Killer (NK) cells in peripheral blood and tumor tissues of cervical pre cancerous lesion and squamous cell carcinoma of cervix patients. This research was an observational analysis study with cross-sectional design of 47 subjects which comprises of 17 cervical pre cancerous lesion patients, 8 early stage squamous cell carcinoma of cervix patients and 22 late stage squamous cell carcinoma of cervix patients in Dr. Soetomo Hospital-Airlangga University teaching hospital, Surabaya. After clinical and histopatologic diagnosis was established, NK cell count was perfomed on the biopsies, and both NK cell count and percentage of activated NK cells was performed on the peripheral blood of those three groups. From this research, it was found that the average number and percentage of activated NK cells within peripheral blood of cervical pre cancerous lesion patients were lower (349.65 cell/μL; 15.13%) compared with early stage carcinoma (552 cell/μL; 18,40%) and late stage carcinoma (590.32 sel/μL; 23.29%). NK cell expression of cervical tumor tissues on three groups are very low, 0.29% on cervical pre cancerous lesion patients; 0.45% on early stage cervical cancer patients; and 0.04% on late stage cervical cancer patients. Significant differences was found in the number of NK cells (p=0.016) and percentage of activated NK cells (p=0.041) within peripheral blood between pre cancerous lesion patients and late stage squamous cell cervical cancer patients, no significant difference was found in the number of NK cells within tumor tissue (p=0.278).
Motivasi Berhenti Merokok pada Perokok Dewasa Muda Berdasarkan Transtheoretical Model (TTM) Esti Rossa Larasati; Wita Saraswati; Henny Utami Setiawan; Silda Sabila Rahma; Agustina Gianina; Cindy Alicia Estherline; Fitri Nurmalasari; Nauri Nabiela Annisa; Indah Septiani; Gesnita Nugraheni
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 5 No. 2 (2018): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (317.265 KB) | DOI: 10.20473/jfiki.v5i22018.85-92

Abstract

Pendahuluan: Merokok telah diketahui menjadi faktor resiko banyak penyakit dan kematian. Meskipun demikian, terdapat peningkatan prevalensi perokok berusia muda. Intervensi untuk meningkatkan angka berhenti merokok diharapkan efektif dilakukan. Desain intervensi tersebut dapat dipengaruhi oleh seberapa tinggi motivasi berhenti merokok. Tujuan: Penelitian ini dilakukan dengan tujuan untuk mengidentifikasi motivasi seseorang untuk berhenti merokok berdasarkan Transtheoretical Model (TTM), untuk menentukan hubungan faktor demografi dan pengetahuan rokok terhadap motivasi berhenti merokok, dan menemukan faktor-faktor yang membedakan motivasi untuk berhenti merokok. Metode: Penelitian ini dilakukan di sekitar kampus B Universitas Airlangga pada September 2018 menggunakan metode survei, rancangan studi cross-sectional dengan teknik accidental sampling. Responden dalam penelitian ini merupakan perokok berusia 17 - 25 tahun (n = 162). Hasil: Dari hasil analisis data diperoleh bahwa tingkat motivasi tertinggi terdapat pada tahap kontemplasi yaitu sebanyak 38,9% (62 responden). Tahap kontemplasi adalah tahap dimana seseorang masih berstatus sebagai perokok aktif, tetapi sudah berkeinginan untuk berhenti merokok dalam 6 bulan ke depan, sehingga masih memiliki kecenderungan untuk membatalkan keinginan berhenti merokok. Profil demografi, seperti uang saku, jumlah teman merokok dan keberadaan perokok di rumah responden tidak berpengaruh signifikan terhadap tingkat motivasi berhenti merokok. Pengetahuan dan intensitas merokok berpengaruh signifikan terhadap motivasi berhenti merokok. Terdapat korelasi antara pengeluaran untuk merokok dan jumlah batang rokok per hari dengan motivasi berhenti merokok (p = 0,000). Kesimpulan: Promosi kesehatan terkait berhenti merokok yang berfokus di kalangan remaja sangat perlu dilakukan. Intervensi yang dapat dilakukan untuk perokok pada tahap kontemplasi adalah mengadakan penyuluhan tentang bahaya merokok dan pemberian informasi adanya NRT (Nicotine Replacement Therapy).
CD4-T Lymphocyte in Cervical Cancer Patients on Pre-and Post-Chemotherapy Endah Indriastuti; Endang Retnowati; Wita Saraswati
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 26, No 1 (2019)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v26i1.1367

Abstract

Introduction : Cervical cancer is a gynecology cancer with the highest incidence in the Dr.Soetomo Hospital, Surabaya. Neoadjuvant chemotherapy with cisplatin has been used to increase radiosensitivy of cancer cells before radiotherapy done in advanced stage cervical cancer patients. This research aimed to know the differences of CD4-T lymphocyte profile in stage IIIB patient before and after chemotheraphy administration.Methods : This research was done in February-September 2018. Seventeen patients out of 31 stage IIIB cervical cancer patients planned to receive neoadjuvan chemotherapy with cisplatin every 3 weeks for 3 series were checked for the CD4+ T lymphocyte count and percentage. The examinations were done before the first and after the third chemotherapy administration.Results : Mean±SD of the CD4-T lymphocyte count before chemotherapy was 817±314 cells/μL and mean±SD of the CD4-T lymphocyte  percentage was 38.96±8.47%. While mean±SD of the CD4-T lymphocyte count after chemotherapy was 881±335 cells/μL and mean±SD of the CD4-T lymphocyte percentage was 39.01±8.50%. There was no significant  difference of CD4-T lymphocyte count between before and after chemotherapy (p=0.471). There was also no significant difference of CD4-T lymphocyte percentage between before and after chemotherapy (p=0.866). Both the CD4-T lymphocyte count and percentage tended to increase in postchemotherapy condition.Conclusion : The CD4-T lymphocyte count and percentage were not significantly different between before and after chemotherapy administration in stage IIIB cervical cancer patients. Both the CD4-T lymphocyte count and percentage tended to increase in postchemotherapy condition.
Profil Sel Natural Killer (NK) dalam Darah Perifer dan Jaringan Tumor Penderita Lesi Prakanker dan Karsinoma Sel Skuamosa Serviks WITA SARASWATI
Indonesian Journal of Cancer Vol 8, No 4 (2014): Oct - Dec 2014
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (3091.165 KB) | DOI: 10.33371/ijoc.v8i4.361

Abstract

This research was performed to investigate the profile of Natural Killer (NK) cells in peripheral blood and tumor tissues of cervical pre cancerous lesion and squamous cell carcinoma of cervix patients. This research was an observational analysis study with cross-sectional design of 47 subjects which comprises of 17 cervical pre cancerous lesion patients, 8 early stage squamous cell carcinoma of cervix patients and 22 late stage squamous cell carcinoma of cervix patients in Dr. Soetomo Hospital-Airlangga University teaching hospital, Surabaya. After clinical and histopatologic diagnosis was established, NK cell count was perfomed on the biopsies, and both NK cell count and percentage of activated NK cells was performed on the peripheral blood of those three groups. From this research, it was found that the average number and percentage of activated NK cells within peripheral blood of cervical pre cancerous lesion patients were lower (349.65 cell/?L; 15.13%) compared with early stage carcinoma (552 cell/?L; 18,40%) and late stage carcinoma (590.32 sel/?L; 23.29%). NK cell expression of cervical tumor tissues on three groups are very low, 0.29% on cervical pre cancerous lesion patients; 0.45% on early stage cervical cancer patients; and 0.04% on late stage cervical cancer patients. Significant differences was found in the number of NK cells (p=0.016) and percentage of activated NK cells (p=0.041) within peripheral blood between pre cancerous lesion patients and late stage squamous cell cervical cancer patients, no significant difference was found in the number of NK cells within tumor tissue (p=0.278).
CD4-T Lymphocyte in Cervical Cancer Patients on Pre-and Post-Chemotherapy Endah Indriastuti; Endang Retnowati; Wita Saraswati
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 26 No. 1 (2019)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v26i1.1367

Abstract

Cervical cancer is a gynecology cancer with the highest incidence in the Dr.Soetomo Hospital, Surabaya. Neoadjuvant chemotherapy with cisplatin has been used to increase radiosensitivy of cancer cells before radiotherapy done in advanced stage cervical cancer patients. This research aimed to know the differences of CD4-T lymphocyte profile in stage IIIB patient before and after chemotheraphy administration. This research was done in February-September 2018. Seventeen patients out of 31 stage IIIB cervical cancer patients planned to receive neoadjuvan chemotherapy with cisplatin every 3 weeks for 3 series were checked for the CD4+ T lymphocyte count and percentage. The examinations were done before the first and after the third chemotherapy administration. Mean±SD of the CD4-T lymphocyte count before chemotherapy was 817±314 cells/μL and mean±SD of the CD4-T lymphocyte  percentage was 38.96±8.47%. While mean±SD of the CD4-T lymphocyte count after chemotherapy was 881±335 cells/μL and mean±SD of the CD4-T lymphocyte percentage was 39.01±8.50%. There was no significant  difference of CD4-T lymphocyte count between before and after chemotherapy (p=0.471). There was also no significant difference of CD4-T lymphocyte percentage between before and after chemotherapy (p=0.866). Both the CD4-T lymphocyte count and percentage tended to increase in postchemotherapy condition. The CD4-T lymphocyte count and percentage were not significantly different between before and after chemotherapy administration in stage IIIB cervical cancer patients. Both the CD4-T lymphocyte count and percentage tended to increase in postchemotherapy condition.
Expression of Yap Signaling Hippo Pathway in Cervical Pre-cancerous Lesions and Cervical Cancer Rizal, M Masrur; Arifa Mustika; Wita Saraswati
Indonesian Journal of Obstetrics and Gynecology Volume 12 No. 3 Jully 2024
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v12i3.1983

Abstract

Abstract Objective: To determine the expression of YAP in cervical pre-cancerous and cervical cancer lesions.Methods: Researchers systematically searched five databases using the checklist for Preferred Reporting Items for Systematic Review and Meta-analyses (PRISMA) guideline and Newcastle-Ottawa Scale (NOS).. Inclusion criteria were the original study of YAP expression in cervical pre-cancerous lesions and cervical cancer, observational and experimental study, and using immunohistochemical techniques. The study protocol was registered in the PROSPERO database of systematic review (IDCRD42023407469). Results: The data search in this study followed the PRISMA Guideline, which includes phases of identification, screening, and inclusion of studies. Initially, 245 articles were identified across five databases: Pubmed (105), ScienceDirect (8), Scopus (29), Web of Science (26), and ProQuest (77). After removing duplicates, 157 studies remained. During the initial screening, 142 studies were excluded, leaving 15 studies for further evaluation. These were assessed based on the use of immunohistochemistry staining for YAP expression and staining result. Subsequently, ten studies were excluded for either not using immunohistochsmistry or lacking staining result, resulting in five studdies selected for qualitative analysis. These five studies were evaluated using the New Ottawa Scale, as detailed in Table 1, and their YAP Expression characteristics are summarized in Table 2. Conclusion: This systematic review showed that YAP expression at all levels ranging from normal tissue, cervical intraepithelial neoplasia, squamous cell carcinoma, and adenocarcinoma had increased expression in the cytoplasm or cell nucleus following the development of cervical cancer and tumorigenesis influenced by intra-tumor heterogeneity for YAP expression. YAP is expressed in the cytoplasm and nucleus, with different functions. YAP expression in these two sites Excessive YAP expression will trigger epithelial changes into mesenchyme which also plays a role in cancer development. This YAP expression also correlates with HPV, in which YAP levels will be maintained and increased.Keywords: cervical cancer, cervical pre-cancerous lesions, YAP expression.
Clinical Symptoms of Patients with Early-Stage and Advanced-Stage Ovarian Cancer Shofwana, Haura Almash Aulia; Hidayati, Hanik Badriyah; Saraswati, Wita; Tjokroprawiro, Brahmana Askandar
Indonesian Journal of Cancer Vol 18, No 3 (2024): September
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i3.1134

Abstract

Background: Ovarian cancer is a malignant neoplasm originating from ovarian cells with different histological types depending on the subtype. It can affect women of all ages. Ovarian cancer ranks third in terms of incidence among diagnosed female cancer patients, following breast and cervical cancer. Ovarian cancer often doesn’t present specific/clear symptoms. As a result, only a small number of patients are diagnosed at an early stage (20%). The study aimed to analyze the clinical complaints experienced by ovarian cancer patients, both in early and advanced stages before diagnosis. Methods: This descriptive cross-sectional study analyzes clinical complaints before the diagnosis of early and advanced-stage ovarian cancer patients. The study was conducted in the Gynecology-Oncology inpatient ward at Dr. Soetomo Regional General Hospital in 2021, utilizing medical record data. Results: A total of 98 patients (21 patients with early-stage, and 77 patients with advanced-stage) were analyzed. The majority of the patients are aged 45-58 years (49%), work as homemakers (32.7%), and are married (63.3%). The three most common complaints experienced by subjects with early-stage ovarian cancer were abdominal/pelvic pain (23.8%), abdominal/pelvic pressure (28.6%), and abdominal distension (42.9%), while in patients with advanced-stage ovarian cancer were abdominal/ pelvic pain (32.7%), abdominal distension (42.9%), and abdominal discomfort (bloating, early satiety, feeling of fullness, frequent belching, heartburn, nausea and vomiting) (44.2%). Conclusions: The three most common clinical complaints among patients before being diagnosed with early and advanced-stage ovarian cancer in the inpatient ward of Dr. Soetomo Regional General Hospital Surabaya in 2021 were similar. The recognition of these complaints and several risk factors are expected to assist in the earlier diagnosis of ovarian cancer.
Co-Authors Agustina Gianina Arifa Mustika Askandar Tjokroprawiro Cindy Alicia Estherline Endang Retnowati Esti Rossa Larasati Fitri Nurmalasari Gesnita Nugraheni Hanik Badriyah Hidayati,* Mohammad Hasan Machfoed,* Kuntoro,** Soetojo,*** Budi Santoso,**** Suroto,***** Budi Utomo****** Henny Utami Setiawan Indah Septiani Indriastuti, Endah Jeremia Alvian Wiranata Nauri Nabiela Annisa PUNGKY MULAWARDHANA, PUNGKY Rizal, M Masrur Shofwana, Haura Almash Aulia Silda Sabila Rahma Tsalitsa Fajrina Jauhari Veithzal Rivai Zainal