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All Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Andi Handayani Tanra
Department of Clinical Pathology, Faculty Medicine, Hasanuddin University/Dr.Wahidin Sudirohusodo Hospital, Makassar
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience

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Diagnostic Value of Platelet Indices in Patients with Pulmonary Embolism Andi Handayani Tanra; Lopa AT; Esa T; Rauf DE
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 27, No 1 (2020)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v27i1.1625

Abstract

Pulmonary embolism is caused by a thrombus that blocks the pulmonary artery. The role of the platelet is mainly relatedto the formation of thrombus. This study aimed to determine the diagnostic value of platelet indices in patients withpulmonary embolism. This study was a retrospective observational research involving 55 patients with and withoutpulmonary embolism at the period of January 2014 and June 2019 at Dr. Wahidin Sudirohusodo Central Hospital, Makassar.The diagnosis of pulmonary embolism was based on CT angiography. Platelet Indices (PI), Mean Platelet Volume (MPV),Platelet Distribution Width (PDW), and plateletcrit (Pct) were analyzed respectively in two groups. Thirty-one (56.3%)patients were diagnosed with pulmonary embolism. There was significant difference of MPV and Pct values betweenembolism and non-embolism group (9.3±1.5 fL vs. 9.5±0.7 fL, p=0.49) and (0.2±0.1% vs. 0.2±0.1%, p=0.82). Contrastingly,there was a significant difference in PDW value between the two groups (13.2±4.9 fL vs. 9.9±1.1 fL, p=0.002). ReceiverOperating Characteristics (ROC) analysis showed cut-off value ≥ 10.5 fL of PDW with a sensitivity of 77.4%, a specificity of75%, Positive Predictive Value (PPV) of 80%, and Negative Predictive Value (NPV) of 72%. Platelet indices (PDW) showed agood diagnostic value on pulmonary embolism disease with a cut-off value ≥ of 10.5fL.
Diagnostic Value of Platelet Indices in Patients with Pulmonary Embolism Andi Handayani Tanra; Lopa AT; Esa T; Rauf DE
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 27 No. 1 (2020)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v27i1.1625

Abstract

Pulmonary embolism is caused by a thrombus that blocks the pulmonary artery. The role of the platelet is mainly related to the formation of thrombus. This study aimed to determine the diagnostic value of platelet indices in patients with pulmonary embolism. This study was a retrospective observational research involving 55 patients with and without pulmonary embolism at the period of January 2014 and June 2019 at Dr. Wahidin Sudirohusodo Central Hospital, Makassar. The diagnosis of pulmonary embolism was based on CT angiography. Platelet Indices (PI), Mean Platelet Volume (MPV), Platelet Distribution Width (PDW), and plateletcrit (Pct) were analyzed respectively in two groups. Thirty-one (56.3%) patients were diagnosed with pulmonary embolism. There was significant difference of MPV and Pct values between embolism and non-embolism group (9.3±1.5 fL vs. 9.5±0.7 fL, p=0.49) and (0.2±0.1% vs. 0.2±0.1%, p=0.82). Contrastingly, there was a significant difference in PDW value between the two groups (13.2±4.9 fL vs. 9.9±1.1 fL, p=0.002). Receiver Operating Characteristics (ROC) analysis showed cut-off value ≥ 10.5 fL of PDW with a sensitivity of 77.4%, a specificity of 75%, Positive Predictive Value (PPV) of 80%, and Negative Predictive Value (NPV) of 72%. Platelet indices (PDW) showed a good diagnostic value on pulmonary embolism disease with a cut-off value ≥ of 10.5fL.
Co-Authors Esa T Lopa AT Rauf DE