Garuda - Garba Rujukan Digital

Saikhu Akhmad Husen

Department Of Biology, Faculty Of Science And Technology, Airlangga University, Surabaya

Author-ID : 3514525

Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Education Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences

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Activity test of various mangosteen (Garcinia mangostana) pericarp extract fractions to decrease fasting blood cholesterol levels and lipid peroxidation activity in diabetic mice Saikhu Akhmad Husen; Dwi Winarni; Firas Khaleyla; Septian Hary Kalqutny
JURNAL PENELITIAN BIOLOGI BERKALA PENELITIAN HAYATI Vol 22 No 1 (2016): December 2016
Publisher : The East Java Biological Society

The objectives of this study were to determine the effect of various fractions of mangosteen (Garcinia mangostana) pericarp extract to the changes of the fasting blood cholesterol and serum malondialdehyde (MDA) levels on diabetic mice (Mus musculus). Thirty 3-4 months old male mice strain BALB/c, weight 20-30 g were divided into six groups. The first group was KN as a non diabetic control group, KD as a diabetic control, KM as a group of diabetic mice treated with metformin, and NP, SP, and P as the treatment groups that were treated by using three different fractions from mangosteen pericarp extract, non polar, semi polar, and polar respectively. The induction of Diabetes mellitus was done by the injection of STZ, and the mice were given a high fat diet treatment to induce the hiperlipidemia condition using lard for three weeks. The blood cholesterol levels were measured in all groups before and after the injection of lard, and day 1, 7, and 14 of treatment as well. The serum MDA level as the indicator of lipid peroxidation were measured by using QuantiChrom TBARS Assay Kit (DTBA-100). The data of cholesterol levels were statistically analyzed by t-test, while the data of serum MDA levels were analyzed by variance analysis followed by Duncan test. The results showed that the polar fraction of mangosteen pericarp had effect to decrease the fasting blood cholesterol level in mice, however the non polar and semi polar fraction had no simmilar effect. All of the fractions has shown significant effect to decrease the serum MDA level in mice.

EFEK PEMBERIAN LARUTAN DIAZINON PER ORAL TERHADAP KERUSAKAN SEL-SEL TUBULI GINJAL MENCIT Saikhu Akhmad Husen; J. Soemartojo; S. Soekamto M
JURNAL PENELITIAN BIOLOGI BERKALA PENELITIAN HAYATI Vol 2 No 2 (1996): December 1996
Publisher : The East Java Biological Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23869/478

One of the pesticide which very common to protect plants from the pest is diazinon. But this pesticide contain neurotoxic organophosphate bound. The organophosphate bound has also an effect on kidney's tissue. Recently the research about effect of diazinon still required. The study was carried out to observe the effect of diazinon on cells of tubuli renalis in mice. This study was used 30 mice, by random sampling became 6 goup. Three groups for controle (K1, K2, and K3) and three groups for treatment (P1, P2, and P3). The controle groups were given 0.5 ml aquadest and the treatment groups were given 150 ppm of 0.5 ml diazinon solution up to 10, 20, and 40 days for P1, P2, and P2 sub sequently. The result showed that the effect of diazinon solution given per oral for the difference time were caused difference demage level on cells ob the tubuli renalis in mice. Keywords : diazinon, cells of tubuli renalis

Finding the Optimized Frequency of Electric Field on The Attempt of Reducing Blood Sugar Level in Type II Diabetes Patients Suhariningsih Suhariningsih; Dwi Winarni; Saikhu Akhmad Husen; Tri Anggono Priyo
Jurnal Vokasi Indonesia Vol 6, No 1 (2018): January - June
Publisher : Program Pendidikan Vokasi Universitas Indonesia

A study has been conducted to test the use of electric fields to lower blood sugar levels on rats with type II Diabetes Mellitus. This study uses male rats (Rattus novergicus), aged 8-12 weeks weighing 150-200 grams, with a total of 31 rats. Therapy was conducted by putting rats in a chamber that emits an electric field every day for 1 hour for 28 days. To search for the optimum frequency of the treatment, frequency variations of 15, 30, 60, and 120 kHz were given. The electrical charge distribution of the air in the room was then measured, whereas mice blood sugar levels were also measured to reveal the effect of the treatment on cell tolerance to sugar, and to come up with the measurement of insulin levels at the end of the treatment. The results of measurements of the electrical charges in the air were very significant generally showing that the treatment with a frequency of 15 to 120 KHz for 4 weeks in the experimental animals could lower their blood sugar (fasting period), but the success rate significantly occurred at a frequency of 15 kHz. The decrease in fasting blood sugar levels after the treatment was probably due to the influence of the treatment (the influence of an electric field) that improved the regulation of insulin receptors. Improvements in the regulation of insulin receptor activities with high gluconeogenesis may be the cause of a decrease in fasting blood sugar levels that is not accompanied by improved cell tolerance to sugar. Keywords: Electric Field, blood sugar levels, insulin levels

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