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All Journal Journal of Islamic Medicine Islamic Review : Jurnal Riset dan Kajian Keislaman Muhammadiyah Journal of Geriatric Muhammadiyah Journal of Midwifery (MyJM)
Fitriyah, Nurin Nadzifatil
[Scopus ID.57195528267] Medical Faculty, UIN Syarif Hidayatullah Jakarta
Arts Humanities Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Hypertension in elderly: A study of hypertension in epigenetic perspective Nurin Nadzifatil Fitriyah; Indah Mardiana
Muhammadiyah Journal of Geriatric Vol 1, No 1 (2020): Muhammadiyah Journal of Geriatric
Publisher : Faculty of Medicine and Health Universitas Muhammadiyah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (471.801 KB) | DOI: 10.24853/mujg.1.1.23-28

Abstract

Background: as is known, epigenetic events are defined as modifications in phenotype or gene expression, which caused by interactions between genes and the environment without changing the order of their nitrogenous bases. This article will discuss the role of epigenetics in one of the degenerative diseases that are often found in the elderly, namely hypertension. In this review article, we will mainly discuss the events of histone modification and DNA methylation, for example, DNA methylation in the CpG islands and the acetylation of histone pathway are identified to limit the development of nephrons, thus opening up to lhypertension-related with exposure to high salt diets. Results: lack of maternal water and protein deficiency have been shown to increase the appearance of the renin-angiotensin system gene in the children. Conclusion: these results indicate targets for the interaction of environmental genes in various conditions of hypertension and essential hypertension.
Childhood Vaccination Decisions during the Pandemic: Tradition, Generational Influence, and Spiritual Perspectives Fitriyah, Nurin Nadzifatil; Maulidina, Akmal
Islamic Review: Jurnal Riset dan Kajian Keislaman Vol 13 No 2 (2024): October 2024
Publisher : Mafapress - Lembaga Penelitian dan Pengabdian Masyarakat (LPPM) IPMAFA Pati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35878/islamicreview.v13i2.1257

Abstract

Background: Vaccination is an attempt to form active immunity in an individual. Vaccination is carried out as a preventive measure against infection, both in adults and children. This study aims to determine the effect of parental attitudes, generational influenced, and spiritual contexts on children's vaccination decisions, in this case, the COVID-19 vaccination. Methods: This study used a cross-sectional online survey method, with parents who have children aged 6–11 and willing to take part in this study as respondents. Data collection was carried out from November 2022 to April 2023. There were 66 participants who met the criteria, and then an analysis was carried out using the Structural Equation Model (SEM) method, which was processed using Partial Least squares (PLS). Results: According to research findings, parents' points of view play an important role in deciding whether to vaccinate their child or not. Up to 58% of respondents said they support vaccinating their children, in this case with the COVID-19 vaccination. Conclussion: Parental attitudes of vaccination in children in this research is strongly influenced by parents' views, so the right approach is needed for parents for the successful implementation of vaccination in children. Other influential factors are spiritual context and generational influence from family regarding COVID-19.
Tingkat Pemahaman Siswi SMAN 1 Sindang Indramayu Mengenai Kanker Serviks dan Faktor Penyebabnya Rahayu, Putri Mega; Hermawan, Oghi; Fitriyah, Nurin Nadzifatil
Muhammadiyah Journal of Midwifery Vol 2, No 1 (2021): Muhammadiyah Journal of Midwifery (MyJM)
Publisher : Faculty of Medicine and Health Universitas Muhammadiyah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (210.554 KB) | DOI: 10.24853/myjm.2.1.21-26

Abstract

Latar Belakang: Kanker serviks merupakan kanker dengan angka kejadian tertinggi ke-2 di Indonesia. Besarnya kasus kanker serviks yang ditemukan, mendorong pertanyaan, seberapa besar pemahaman masyarakat, terutama remaja mengenai kanker serviks. Tujuan: Mengetahui bagaimana tingkat pemahaman siswi SMAN 1 Sindang Indramayu mengenai kanker serviks dan faktor yang menyebabkannya. Metode: Penelitian ini menggunakan metode deskriptif dengan cara pengambilan data secara kuesioner online. Pengambilan data dilakukan pada bulan November- Desember tahun 2020, dengan jumlah sampel sebanyak 85 siswi. Hasil: Berdasarkan hasil penelitian, diketahui bahwa tingkat pemahaman siswi SMAN 1 Sindang Indramayu adalah cukup. Kesimpulan: Diperlukan tindak lanjut untuk mengatasi hal tersebut.
Potensi Fenol pada Phyllanthus niruri L. sebagai Immunomodulator Tuberkulosis Fitriyah, Nurin Nadzifatil
Journal of Islamic Medicine Vol 9, No 1 (2025): JOURNAL OF ISLAMIC MEDICINE EDISI MARET 2025
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v9i1.32284

Abstract

Background:   One of the goals set in the Sustainable Development Goals (SDGs) is to ensure healthy lives and promote well-being for all people at all ages, one of which is through the control of Tuberculosis (TB). Indonesia is the country with the second highest TB rate in the world. Standard treatment using a combination of anti-TB drugs (RHZE) is effective, but carries the risk of hepatotoxic side effects. Indonesia has great potential in the development of phytopharmaceuticals, one of which is Phyllanthus niruri, which contains bioactive compounds such as lignans, tannins, polyphenols, alkaloids, terpenoids, and flavonoids. These compounds can improve the immune system and have the potential to be used as adjuvants in OAT therapy to strengthen the effectiveness of TB treatment and reduce side effects. .  Objectif  Examining the use of Phyllanthus niruri and its contents and benefits as an immunomodulator for Tuberculosis (TB). Methods  This study uses a literature review with sources from Science Direct, Google Scholar, Pubmed NCBI, and Taylor Francis Online, using the keywords "Phyllanthus niruri" AND "tuberculosis" AND "immunomodulator" obtained 139 articles. Furthermore, re-filtering was carried out based on the content so that 16 articles were obtained.  Results The results of the study showed that the phytochemical content, especially phenol, can induce the proliferation of peripheral blood mononuclear cells, increase the release of Nitric Oxide, and increase the phagocytic activity of macrophages, while other contents, namely flavonoids and alkaloids, act as hepatoprotective. Conclusion :  Phyllanthus niruri is effective as an adjuvant for OAT therapy to increase immunity and accelerate TB healing.
Co-Authors Hermawan, Oghi Indah Mardiana Maulidina, Akmal Rahayu, Putri Mega