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All Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Fitriani Mangarengi
Department of Clinical Pathology, Faculty of Medicine, Hasanuddin University/Dr. Wahidin Sudirohusodo Hospital, Makassar
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience

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Serum Beta-Trace Protein versus Glomerulus Filtration Rate as a Predictor for Kidney Function among Hypertensive Patients Ranisa Handayani; Yuyun Widaningsih; Fitriani Mangarengi; Uleng Bahrun
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 27, No 2 (2021)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v27i2.1618

Abstract

Beta-Trace Protein (BTP) is a low-molecular-weight glycoprotein that can convert prostaglandin H2 into prostaglandin D2 and is associated with the vascular function's alteration. Serum beta-trace protein has been proposed as a promising marker in predicting kidney function in hypertensive patients. This study aimed to analyze the correlation between BTP and glomerulus filtration rate, particularly in hypertensive patients. A cross-sectional survey was conducted on 70 hypertensive participants admitted to Dr. Wahidin Sudirohusodo Hospital from July-August 2019. Beta-trace protein, serum urea, creatinine, blood pressure, and anthropometric were measured. The Glomerulus Filtration Rate (GFR) with Cockcroft Gault was graded using GFR stages. The hypertension was graded according to the category of the European Society of Cardiology (ESC) 2018. A descriptive test, Kruskal-Wallis test, Fisher exact test, Spearman correlation test, and logistic regression test were performed at a confidence level of 95%. Significant differences were found between the age, systole, diastole, blood urea, creatinine, and GFR (p=< 0.05). There was a significant difference between GFR and the degree of hypertension (p=< 0.001), but no differences were found in the mean value of BTP and the degree of hypertension (p=0.348). A significant negative correlation was found between GFR and BTP (p=0.028, r = -0.263). Logistic regression test s showed that the increased BTP led to 2.591 times greater possibility of end-stage renal disease with GFR < 15 mL/min/ 2 1.73 m (crude odds ratio 95% CI 1.168-5.475). Serum beta-trace protein possesses a prognostic ability of glomerulus filtration rate and can be used to predict the odd of end-stage renal disease in hypertensive patients.
Analysis of Endocan Levels in Hypertensive Patients as Risk Factors of Chronic Kidney Disease Suryani Jamal; Uleng Bahrun; Ibrahim Abdul Samad; Fitriani Mangarengi; Hasyim Kasim; Ilham Jaya Patellongi
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 27, No 1 (2020)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v27i1.1571

Abstract

This study aimed to analyze endocan levels as a marker of endothelial dysfunction in the control group, patients withstage I hypertension, stage II hypertension, and patients with end-stage renal disease. Endocan levels were measured withESM-1 (endocan) kit by Enzyme-Linked Immunosorbent Assay (ELISA) method. This study used a cross-sectional methodand was conducted in Dr. Wahidin Sudirohusodo Hospital, Makassar and Hasanuddin University Hospital from Septemberto October 2017. There were 83 samples in this study, consisting of 12 samples in the control group, 22 samples of stage Ihypertension, 28 samples of stage II hypertension, and 21 samples of end-stage renal disease aged 20-90 years old. Thisstudy showed significantly higher endocan levels in patients with stage II hypertension and end-stage renal disease(p< 0.05). Endocan levels were significantly higher (p<0.05) in patients with end-stage renal disease compared with thecontrol group and patients with stage I hypertension; but not significantly higher (p > 0.05) compared to patients with stageII hypertension. Also, the median of endocan levels in patients with the end-stage renal disease was higher (309,850 ng/L)compared to patients with stage II hypertension (273,050 ng/L).
Analysis of Endocan Levels in Hypertensive Patients as Risk Factors of Chronic Kidney Disease Suryani Jamal; Uleng Bahrun; Ibrahim Abdul Samad; Fitriani Mangarengi; Hasyim Kasim; Ilham Jaya Patellongi
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 27 No. 1 (2020)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v27i1.1571

Abstract

This study aimed to analyze endocan levels as a marker of endothelial dysfunction in the control group, patients with stage I hypertension, stage II hypertension, and patients with end-stage renal disease. Endocan levels were measured with ESM-1 (endocan) kit by Enzyme-Linked Immunosorbent Assay (ELISA) method. This study used a cross-sectional method and was conducted in Dr. Wahidin Sudirohusodo Hospital, Makassar and Hasanuddin University Hospital from September to October 2017. There were 83 samples in this study, consisting of 12 samples in the control group, 22 samples of stage I hypertension, 28 samples of stage II hypertension, and 21 samples of end-stage renal disease aged 20-90 years old. This study showed significantly higher endocan levels in patients with stage II hypertension and end-stage renal disease (p< 0.05). Endocan levels were significantly higher (p<0.05) in patients with end-stage renal disease compared with the control group and patients with stage I hypertension; but not significantly higher (p > 0.05) compared to patients with stage II hypertension. Also, the median of endocan levels in patients with the end-stage renal disease was higher (309,850 ng/L) compared to patients with stage II hypertension (273,050 ng/L).
Serum Beta-Trace Protein versus Glomerulus Filtration Rate as a Predictor for Kidney Function among Hypertensive Patients Ranisa Handayani; Yuyun Widaningsih; Fitriani Mangarengi; Uleng Bahrun
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 27 No. 2 (2021)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v27i2.1618

Abstract

Beta-Trace Protein (BTP) is a low-molecular-weight glycoprotein that can convert prostaglandin H2 into prostaglandin D2 and is associated with the vascular function's alteration. Serum beta-trace protein has been proposed as a promising marker in predicting kidney function in hypertensive patients. This study aimed to analyze the correlation between BTP and glomerulus filtration rate, particularly in hypertensive patients. A cross-sectional survey was conducted on 70 hypertensive participants admitted to Dr. Wahidin Sudirohusodo Hospital from July-August 2019. Beta-trace protein, serum urea, creatinine, blood pressure, and anthropometric were measured. The Glomerulus Filtration Rate (GFR) with Cockcroft Gault was graded using GFR stages. The hypertension was graded according to the category of the European Society of Cardiology (ESC) 2018. A descriptive test, Kruskal-Wallis test, Fisher exact test, Spearman correlation test, and logistic regression test were performed at a confidence level of 95%. Significant differences were found between the age, systole, diastole, blood urea, creatinine, and GFR (p=< 0.05). There was a significant difference between GFR and the degree of hypertension (p=< 0.001), but no differences were found in the mean value of BTP and the degree of hypertension (p=0.348). A significant negative correlation was found between GFR and BTP (p=0.028, r = -0.263). Logistic regression test s showed that the increased BTP led to 2.591 times greater possibility of end-stage renal disease with GFR < 15 mL/min/ 2 1.73 m (crude odds ratio 95% CI 1.168-5.475). Serum beta-trace protein possesses a prognostic ability of glomerulus filtration rate and can be used to predict the odd of end-stage renal disease in hypertensive patients.
Co-Authors Ibrahim Abdul Samad Ilham Jaya Patellongi Kasim, Hasyim Ranisa Handayani Suryani Jamal Uleng Bahrun Yuyun Widaningsih