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All Journal Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia)
Azhari Azhari
Faculty of Medicine University of Sriwijaya/ Dr. Mohammad Hoesin Hospital Palembang
Health Professions Medicine & Pharmacology Public Health

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Transforming Growth Factor β1 and Tropoelastin Expression in Uterine Prolapse Alvilusia Alvilusia; Amir Fauzi; Azhari Azhari; Wresnindyatsih Wresnindyatsih; Irsan Saleh
Indonesian Journal of Obstetrics and Gynecology Volume. 4, No. 2, April 2016
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (577.898 KB) | DOI: 10.32771/inajog.v4i2.78

Abstract

Objective: To know the correlation of the expression of transforming growth factor beta (TGF-β1) and tropoelastin in uterine prolapse. Method: A cross-sectional study of 30 subjects suffered from uterine prolapse in the Department of Obstetrics and Gynecology Dr. Mohammad Hoesin hospital Palembang. The study was conducted since December 1st, 2014 until July 31st, 2015. The sample was from the sacrouterine ligament and immunohistochemical examination was conducted to see the expression of TGF-β1 and tropoelastin. Result: Of the 30 subjects obtained, the expression of TGF-β1 was on 30 subjects consisting of 18 (60%) for weak expression and 12 (40%) for strong expression. Meanwhile, the strong tropoelastin expression was on 18 subjects (60%) and weak tropoelastin expression on 12 subjects (40%). There was a positive correlation between TGF-β1 and tropoelastin expression with moderate correlation (p=0.014; r=0.44). Conclusion: There is a positive correlation between the TGF-β1 and tropoelastin expression of sacrouterine ligament in uterine prolapse with moderate correlation. [Indones J Obstet Gynecol 2016; 4-2: 70-74] Keywords: transforming Growth Factor Beta 1, tropoelastin, uterine prolapse
Impact of Uterine Prolapse Surgery on Improvement of Bowel Symptoms: Dampak Operasi Prolapsus Uteri pada Perbaikan Gejala Sistem Pencernaan Zulfadli Zulfadli; Amir Fauzi; Azhari Azhari; Theodorus Theodorus
Indonesian Journal of Obstetrics and Gynecology Volume. 2, No. 3, July 2014
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (118.723 KB) | DOI: 10.32771/inajog.v2i3.396

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Objective: To find the effectiveness of uterine prolapse surgery in patients with bowel symptoms. Method: Clinical trial without comparison study of 32 consecutive women who underwent surgery for grade III and IV uterine prolapse with bowel symptoms. Bowel symptoms score was evaluated before and three months after surgery by using the Australian Pelvic Floor Questionnaire. Data was analyzed using SPSS version 20. Result: There were significant mean differences between bowel symptoms score three months after surgery for grade III and IV uterine prolapse and before surgery although there were patients with persistent symptoms. Bowel symptoms scores include constipation, flatus incontinence, fecal incontinence, fecal urgency, defecation frequency, defecation consistency, incomplete bowel emptying, laxative use, and frequency of defecation disorder score, with p<0.001 and 95% CI. Conclusion: Uterine prolapse surgery was effective to improve quality of life in grade III-IV uterine prolapse patients with bowel symptoms. Keywords: bowel symptoms, cystocele, rectocele, uterine prolapse surgery
Co-Authors Alvilusia Alvilusia Amir Fauzi Irsan Saleh Theodorus Theodorus Wresnindyatsih Wresnindyatsih Zulfadli Zulfadli