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All Journal Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia)
ANDRIJONO ANDRIJONO
Faculty of Medicine University of Indonesia/ Dr. Cipto Mangunkusumo General Hospital Jakarta
Health Professions Medicine & Pharmacology Public Health

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Primary Prevention of Gynecologic Cancers ANDRIJONO ANDRIJONO
Indonesian Journal of Obstetrics and Gynecology Volume. 30, No. 4, October 2006
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (124.631 KB)

Abstract

Pendahuluan: Terdapat tiga jenis kanker yang banyak diderita oleh wanita dalam bidang ginekologi, yaitu kanker serviks, kanker ovarium dan kanker endometrium. Patofisiologi kanker serviks hampir dikenal dengan baik, sedangkan patofisiologi kanker ovarium mulai terbuka, dan patofisiologi kanker endometrium juga mulai diketahui. Dengan dasar tersebut dilakukan penelitian terhadap faktor risiko timbulnya kanker ginekologi. Pengenalan faktor risiko yang didapat dari penelitian epidemiologi menjadi dasar untuk melakukan upaya pencegahan primer kanker ginekologi. Pencegahan primer dilakukan dengan memberikan nasihat dan terapi yang mempunyai pengaruh menurunkan risiko timbulnya kanker ginekologi. Tujuan: Menyampaikan kebijakan pencegahan primer kanker ginekologi berdasarkan hasil penelitian epidemiologi. Bahan dan cara kerja: Kajian pustaka. Hasil: Kanker serviks risikonya dapat diturunkan dengan menghindari pola pasangan ganda, menghindari merokok, mengkonsumsi makanan yang kaya vitamin C. Kanker ovarium risikonya dapat diturunkan dengan memberi kontrasepsi oral, menyusui, sterilisasi ataupun histerektomi. Kanker endometrium dapat diturunkan risikonya dengan memberikan kontrasepsi oral kombinasi, menurunkan berat badan. Kesimpulan: Dapat dilakukan upaya menurunkan risiko timbulnya kanker ginekologi melalui pencegahan primer. [Maj Obstet Ginekol Indones 2006; 30-4: 245-8] Kata kunci: pencegahan primer, kanker ginekologi
Uterine Perforation on Invasive Hydatidiform Mole during EMACO Treatment: Perforasi Uterus pada Mola Hidatidosa Invasif saat Tatalaksana EMACO Bram Pradipta; Andrijono Andrijono; Sigit Purbadi; Tofan W Utami
Indonesian Journal of Obstetrics and Gynecology Volume. 2, No. 3, July 2014
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (213.341 KB) | DOI: 10.32771/inajog.v2i3.400

Abstract

Objective: Improving skill and knowledge to recognize and manage a rare case of uterine perforation on invasive hydatidiform mole. Method: Case report. Result: A 42 years old Indonesian woman, Parity 2 Abortus 2 with history of 2 c-sections and 2 curettage, came with chief complaint of recurrent vaginal bleeding since 4 months before admission. Patient had a history of previous curettage with indication of hydatidiform mole and recurrent bleeding with no histopathology results. On examination we found a vesicular mass with infiltration, destroying the right-front uterine corpus, size 8x6 cm with an internal echo mass. Chest x-ray showed multiple nodules in the lung. The patient, considered as low risk Gestational Trophoblastic Neoplasia patient with FIGO Score of 6, underwent chemotherapy with 2 series of methotrexate . Due to the non-declining level of -hCG, the regimen was added with EMACO. In the process of chemotherapy, the pa-tient’s-hCG declined but then she complained of major abdominal pain. Exploratory laparotomy was performed and we found a mass sized 5x5x5 cm on the right side of the uterus at the broad ligament with a rupture at the posterior part of the mass sized 0.5x0.5 cm. Upon incision of the uterus, we found a mass from the right side protruding to the isthmus of the uterus. Histopathology showed necrosis, blood and chorionic villi in myometrium corresponding to invasive mole. Patient was then given another 5 series of EMACO and her condition was unremarkable during the remaining course of treatment. Conclusion: Invasive mole treatment is determined based on the risk factors. Uterine perforation still occurred in this case regardless of the decreasing hCG level during EMACO treatment. It emphasizes the importance of clinical examination as chemotherapy responsiveness. Long-term treatment can have a good prognosis but good collaboration between the gynecologist and the patient is essential. Keywords: EMACO, invasive mole, perforation
Co-Authors Bram Pradipta Sigit Purbadi Tofan W Utami