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Efendi Lukas

Faculty of Medicine University of Hasanuddin/ Dr. Wahidin Sudirohusodo Hospital Makassar

Author-ID : 3520843

Health Professions Medicine & Pharmacology Public Health

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Articles

Expression of Tenascin in the Uterosacral Ligament is Stronger in Women with Pelvic Organ Prolapse: Tenascin pada Ligamentum Sakrouterina Diekspresikan lebih kuat pada Perempuan dengan Prolaps Organ Panggul Eny Lusiadewi; Trika Irianta; Efendi Lukas
Indonesian Journal of Obstetrics and Gynecology Volume. 1, No. 4, October 2013
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: This study aimed to compare the expression of tenascin uterosacral ligament in women with and without pelvic organ prolapsen (POP). Methods: The research was carried out in Dr. Wahidin Sudirohusodo Hospital and other educational hospitals of obstetrics and gynecology division UNHAS Faculty of Medicine, which began on January 1st, 2011 until April 2012. This study assessed the expression of tenascin in 35 women with POP levels III and IV, and the controls were 35 women without POP. Tenascin expression was assessed by immunohistochemical examination using tenascin antibody staining (mouse monoclonal antibody Novacastra tenascin C, code NCL-Tenas C). The research was carried out cross sectional. Sampling was done by consecutive sampling. Data processed by the chi-square. The significance level used was 0.05. Results: The results showed that the characteristics of research subjects based on age, education, parity, labor history, history of big babies, not statistically significant. This indicates that the variable does not affect the calculation of the research data. While the characteristics of menopausal status and body mass index (BMI), from the analysis of risk factors for POP is associated significantly with a higher intensity of tenascin in post-menopausal status and BMI> 25 (overweight) (p <0.05). Expression of tenascin in the sample are significantly more powerful, the weak expression (8.6%), moderate (40.0%), and strong (51.4%) than without pelvic organ prolapsed. Expression of tenascin in the control, intensity tenascin weak (77.1%), moderate (20.0%), and strong (2.9%). Conclusion: Expression of tenascin uterosacral ligament was stronger in women with POP compared with a weaker expression of tenascin in women without POP. Keywords: pelvic organ prolapse, risk factors, tenascin

Elastin Expression is the Strongest Risk Factor for Developing Pelvic Organ Prolapse: Tenascin pada Ligamentum Sakrouterina Diekspresikan lebih kuat pada Perempuan dengan Prolaps Organ Panggul Djusiana Cessaria; Trika Irianta; Efendi Lukas
Indonesian Journal of Obstetrics and Gynecology Volume. 1, No. 4, October 2013
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To compare elastin expression in the anterior vaginal wall of women with and with no pelvic prolapse. Methods: The research was conducted in RS Dr. Wahidin Sudirohusodo and other network hospitals of Obstetrics and Gynecology Department of Hasanuddin University, Makassar. Full-thickness specimens were obtained from the anterior vaginal wall of women having a large prolapse repaired (stage III or IV; prolapse group, 34) and the same location in patients with no prolapse having abdominal and vaginal hysterectomy (control group, 35). The expression of elastin was measured by immunohistochemistry on tissue sectioned. The examiner was unaware of sample identity and the patientsâ€™ clinical history. The result then analyzed with p<0.05 considered significant. Results: The result of this research shows that with exception of history of bearing baby > 4000 gr weight (p=0.572); age, parity, menopausal status, and body mass index were significantly different between the groups (0.001; 0.035; 0.011; 0.002; respectively). Immunohistochemical staining indicated that elastin expression in the prolapse group was lower (p=0.009). Elastin expression appeared to be stable with increasing of age, parity, menopausal status, history of bearing baby 4000 gr. weight and Body mass Index in the prolapse group. But multiple logistic regression revealed that elastin have the highest influence to prolapse among the risk factors mentioned (Exp.B =6.252). Conclusion: In this case-control study, the elastin expression were significantly lower in the vaginal wall of patients with a large prolapse. Instead of influence by other risk factors, elastin is the strongest risk factor for developing prolapse among other risk factors. This result is expected to be able to give explanation for the development of prolapse in women without risk factors such is young women and nullipara. Keywords: elastin, prolapse, women

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