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All Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Ni Nyoman Mahartini
Department of Clinical Pathology, Faculty of Medicine, Udayana University/Sanglah Hospital, Denpasar
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience

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Relationship between Atherogenic Index of Plasma with HbA1c Levels in Type 2 Diabetes Mellitus Patients Ni Putu Sukma Sumantri Prabandari; Ida Ayu Putri Wirawati; Ni Nyoman Mahartini
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 28, No 1 (2021)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v28i1.1743

Abstract

Type 2 Diabetes Mellitus (T2DM) is a global health problem due to an increasing prevalence and incidence. HbA1c as aparameter for glycemic control is still above the desired target of 7%. Atherogenic Index of Plasma (AIP) is predicted to be anindicator of cardiovascular disease risk in T2DM. Dyslipidemia in T2DM patients showed a result of increased triglycerideand decreased HDL cholesterol levels. This study aimed to determine the relationship between HbA1c and AIP, triglycerides,and HDL cholesterol in T2DM patients. An analytical observational study using a cross-sectional method on 74 DMT2patients who underwent HbA1c and lipid profile examinations in January-March 2020. Atherogenic index of plasma wascalculated by the logarithmic equation (triglycerides/HDL cholesterol). Data were analyzed by SPSS 25.0. The relationshipbetween HbA1c with AIP, triglycerides, and HDL cholesterol using the Pearson correlation test. Atherogenic index of plasma(0.25±0.25) and triglycerides (211.92±146.09 mg/dL) were found to be higher in the poor glycemic control group (HbA1c> 7%) than AIP (-0.04±0.20) and triglycerides (108.96±38.96 mg/dL) in the good glycemic control group (p < 0.05). HDLcholesterol (40.08±12.64 mg/dL) was found to be higher in the poor glycemic control group than HDL cholesterol(52.28±18.12 mg/dL) in the good glycemic control group (p < 0.05). There was a significant positive correlation betweenHbA1c and AIP (r=0.411, p=0.000), HbA1c with triglycerides (r=0.418, p=0.000), and a significant negative correlationbetween HbA1c and HDL cholesterol (r=-0.233, p=0.046). Insulin resistance can cause lipid metabolism disorders,inflammation, oxidative stress, and coagulation disorders. Maintaining glycemic control and lipid control plays an importantrole in preventing diabetes complications. There is a significant positive correlation between HbA1c and AIP, HbA1c andtriglycerides, and a significant negative correlation between HbA1c and total cholesterol in T2DM patients.
Relationship between Atherogenic Index of Plasma with HbA1c Levels in Type 2 Diabetes Mellitus Patients Ni Putu Sukma Sumantri Prabandari; Ida Ayu Putri Wirawati; Ni Nyoman Mahartini
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 28 No. 1 (2021)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v28i1.1743

Abstract

Type 2 Diabetes Mellitus (T2DM) is a global health problem due to an increasing prevalence and incidence. HbA1c as a parameter for glycemic control is still above the desired target of 7%. Atherogenic Index of Plasma (AIP) is predicted to be an indicator of cardiovascular disease risk in T2DM. Dyslipidemia in T2DM patients showed a result of increased triglyceride and decreased HDL cholesterol levels. This study aimed to determine the relationship between HbA1c and AIP, triglycerides, and HDL cholesterol in T2DM patients. An analytical observational study using a cross-sectional method on 74 DMT2 patients who underwent HbA1c and lipid profile examinations in January-March 2020. Atherogenic index of plasma was calculated by the logarithmic equation (triglycerides/HDL cholesterol). Data were analyzed by SPSS 25.0. The relationship between HbA1c with AIP, triglycerides, and HDL cholesterol using the Pearson correlation test. Atherogenic index of plasma (0.25±0.25) and triglycerides (211.92±146.09 mg/dL) were found to be higher in the poor glycemic control group (HbA1c> 7%) than AIP (-0.04±0.20) and triglycerides (108.96±38.96 mg/dL) in the good glycemic control group (p < 0.05). HDL cholesterol (40.08±12.64 mg/dL) was found to be higher in the poor glycemic control group than HDL cholesterol (52.28±18.12 mg/dL) in the good glycemic control group (p < 0.05). There was a significant positive correlation between HbA1c and AIP (r=0.411, p=0.000), HbA1c with triglycerides (r=0.418, p=0.000), and a significant negative correlation between HbA1c and HDL cholesterol (r=-0.233, p=0.046). Insulin resistance can cause lipid metabolism disorders, inflammation, oxidative stress, and coagulation disorders. Maintaining glycemic control and lipid control plays an important role in preventing diabetes complications. There is a significant positive correlation between HbA1c and AIP, HbA1c and triglycerides, and a significant negative correlation between HbA1c and total cholesterol in T2DM patients.
Anti- N-MethyL-D-Aspartate Receptor Encephalitis in Children Infected with Herpes Simplex Ni Komang Krisnawati; Ni Kadek Mulyantari; Ni Nyoman Mahartini
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 29 No. 3 (2023)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v29i3.1835

Abstract

Herpes Simplex Virus (HSV) is a common cause of infectious encephalitis in children, which can lead to severe neurological sequels. There is a new perspective suggesting that herpes simplex encephalitis plays an important role in triggering the synthesis of NMDA receptor antibodies. There have been no data on the incidence of anti-NMDA receptor encephalitis in Indonesia. Herpes simplex encephalitis was found in these patients as a risk factor for anti-NMDA receptor encephalitis. A 9-year-old male patient complained of seizures such as jerking of the right hand and smacking of the lips along with fever for 4 days before being admitted to the hospital. Complaints began with slurred speech and t   inability of fingers to hold objects for the previous 8 days. From the physical examination, it was reported that the patient looked seriously ill, blood pressure was 110/80 mmHg, pulse was 117 beats per minute, the temperature was 38.5 C, and respiratory rate was 24 times per minute. Another physical examination was within normal limits. The results of a complete blood count at the time of initial treatment of patients showed mild leukocytosis due to a mild increase in monocytes, whereas blood gas and electrolyte analysis showed hypoventilation at the beginning of hospitalization in which mixed acid-base disturbance, respiratory acidosis, and metabolic alkalosis occurred. Analysis of cerebrospinal fluid in these patients showed mononuclear pleocytosis and the results of immunoserological test in serum indicated HSV1 and HSV2 infection and detected anti-NMDA receptor. Both clinical and laboratory findings in this study supported encephalitis. Herpes simplex virus infection can be a risk factor for patients suffering from anti-NMDA receptor encephalitis.
Co-Authors Ida Ayu Putri Wirawati Ni Kadek Mulyantari Ni Komang Krisnawati Ni Putu Sukma Sumantri Prabandari