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Elshinta Riantica
Institut Teknologi Sepuluh Nopember
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Produk Sabun Transparan Berbahan Herbal di Desa Oro-Oro Ombo, Tlekung, Junrejo, Batu Malang, Provinsi Jawa Timur Awik Puji Dyah Nurhayati; Elshinta Riantica; Noor Nailis Saa’dah; Edwin Setiawan; Nova Maulidina Ashari; Adik Mayang Indiani; Agus Wahyudi; Ratna Rintaningrum; Ni Wayan
JURPIKAT (Jurnal Pengabdian Kepada Masyarakat) Vol 1 No 2 (2020)
Publisher : Politeknik Dharma Patria

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37339/jurpikat.v1i2.317

Abstract

Pengolahan empon empon di Desa Oro-oro Ombo-Tlekung-Junrejo-Batu Malang, Provinsi Jawa Timur masih sederhana, yaitu hanya dijual dalam kondisi segar atau produk jamu tradisional, belum dilakukan pengembangan teknologi menjadi produk herbal yang bernilai ekonomi tinggi. Solusi yang diajukan dalam kegiatan pengabdian ini adalah inovasi teknologi pembuatan sabun herbal transparan dari jahe merah, lidah buaya dan bunga melati. Metode pembuatan dilakukan dengan teknik saponifikasi. Hasil uji organoleptik dan efektivitas menunjukkan bahwa formulasi sabun yang paling baik adalah total bahan herbal sebanyak 1,5 g yang tersusun oleh 0,5 g ekstrak cair bunga melati; 0,4 g bubuk jahe merah; 0,6 g gel lidah buaya. Kesimpulan dari kegiatan ini bahwa formula sabun transparan yang paling baik adalah formula A yaitu formula ekstrak herbal 1,5 g. Selain itu kegiatan ini mendapat dukungan dari pemerintah Kota Batu, apparat desa dan warga di Desa Oro Oro Ombo
An Activity of Flavonoid Derived Compounds from Medinilla speciosa Extract as Anti-hyperpigmentation against Tyrosinease Proteins with In Silico Methods elshinta riantica; Awik Puji Dyah Nurhayati; Noor Nailis Sa’adah
Jurnal Ilmiah Kesehatan Vol 17 No 02 (2024): Jurnal Ilmiah Kesehatan (Journal of Health Science) 
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/jhs.v17i02.5107

Abstract

Parijoto (Medinilla speciosa), a typical plant from Indonesia, contains flavonoid compounds as antioxidants. It is able to depigment skin by inhibiting tyrosinase activity during melanogenesis, or melanin formation. Melanogenesis occurs through UV light exposure; it stimulates ROS production and triggers the formation of free radicals and melanogenesis. If not prevented, it will have negative impacts on health. Currently, there is no further research regarding the existence of flavonoid compound derivatives found in parijoto fruit. The aim of this research is to initially identify potential flavonoid derivative compounds as tyrosinase inhibitors using in silico methods. The results can be used as an initial reference for making products based on natural ingredients with minimal side effects. This research uses a bioinformatics approach with the molecular docking method of ligands towards proteins. The stages in this research include: downloading and preparing receptors and ligands; docking with Autodock Vina; visualization of results with Biovia Discovery Studio; data analysis; and discussion. The analysis is carried out by looking at the affinity energy values and complex conformation between the receptor-ligand. The results show flavonoid derivative compounds have the potential to act as tyrosinase inhibitors, as proven by compounds interactions with the active site of tyrosinase to produce the amino acid residues phenylalanine, proline, asparagine, arginine, and histamine. Produce respective affinity energy values, namely -8.9; -7.7; -7.6; -7.5; -7.5; and 7.4 kcal/mol for chalcone, catechin, flavonol, flavanol, flavone, and flavonone compounds. Meanwhile, the comparison compound used is kojic acid, with an affinity energy of -5.5 kcal/mol.
Co-Authors Adik Mayang Indiani Agus Wahyudi Awik Puji Dyah Nurhayati Awik Puji Dyah Nurhayati Edwin Setiawan Ni Wayan Noor Nailis Saa’dah Noor Nailis Sa’adah Nova Maulidina Ashari Ratna Rintaningrum