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All Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research Bioscientia Medicina : Journal of Biomedicine and Translational Research Stigma : Jurnal Matematika dan Ilmu Pengetahuan Alam Unipa
I Kadek Putra Dwipayana
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Biochemistry, Genetics & Molecular Biology Immunology & microbiology Mathematics Medicine & Pharmacology Neuroscience

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KORELASI KADAR KOLESTEROL TOTAL DAN LDL SERUM TIKUS HIPERKOLESTEROLEMIA SETELAH PEMBERIAN EKSTRAK DAUN SALAM (Eugenia polyantha) Putu Oky Ari Tania; I Kadek Putra Dwipayana; Kadek Adi Sudarmika
STIGMA: Jurnal Matematika dan Ilmu Pengetahuan Alam Unipa Vol 11 No 01 (2018)
Publisher : FMIPA : Universitas PGRI Adi Buana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36456/stigma.vol11.no01.a1509

Abstract

Penggunaan herbal belakangan banyak ditemukan, terutama sebagai tanaman obat. Daun salam (Eugenia polyantha) adalah herbal yang banyak digunakan sebagai obat. Daun salam memiliki bahan aktif flavonoid, tannin dan vitamin B3 (niasin). Banyak penelitian menyatakan bahwa daun salam bermanfaat sebagai antikolesterol. Hiperkolesterol dapat terjadi dari asupan makanan tinggi lemak yang berkorelasi terhadap terjadinya aterosklerosis dan bermacam masalah kesehatan lainnya. Aterosklerosis sangat terkait dengan peningkatan kadar LDL. Tingginya kadar LDL sebagai faktor risiko aterosklerosis. oleh karena itu penelitian ini bertujuan untuk mengetahui korelasi antara kolesterol dan LDL pada tikus hiperkolesterol yang diobati dengan ekstrak daun salam. Desain penelitian ini adalah penelitian eksperimental dengan hewan coba ditikus jantan yang dibagi mejadi 4 kelompok yaitu KP, KN, P1, dan P2 semua tikus dikondisikan hiperkolesterolemia dengan pemberian diet tinggi lemak. P1 dan P2 adalah kelompok tkus hiperkolesterolemia yang diberikan ekstrak daun salam masing-masing dosis 0,72 dan 1,80 gram. Pada akhir perlakuan semua kelompok diterminasi dan diisolasi darahnya untuk dihitung kadar kolesterol total dan LDL pada tiap ekor tikus. Pada KP; KN; P1 dan P2 didapatkan rerata kadar kolesterol total adalah 37,4; 36,6; 44,8; dan 32,4 mg/dL, sedangka kadar LDL serum adalah 27,8; 23,8; 31,8 dan 25. Hasil uji statistik dengan korelasi Pearson menunjukkan signifikansi (2-tailed) sebesar 0,007 dan Pearson Correation sebesar 1. Dapat disimpulkan bahawa ada korelasi yang kuat antara kadar kolesterol total dan kadar LDL pada serum.
Navigating Diagnostic Constraints in Pediatric Herpes Simplex Encephalitis: Successful Empirical Acyclovir Therapy without PCR Confirmation I Kadek Putra Dwipayana; Romy Windiyanto
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 5 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i5.1596

Abstract

Background: Herpes simplex encephalitis is an acute or subacute disease associated with focal or global cerebral dysfunction caused by herpes simplex virus type 1 or type 2. Without adequate antiviral administration, the mortality rate reaches 70 percent, with only 9 percent of survivors returning to normal function. While cerebrospinal fluid polymerase chain reaction testing is the gold standard for diagnosis, its availability is severely restricted in resource-limited clinical environments. Case presentation: We report the case of a 4-year-old girl who presented with a profoundly decreased level of consciousness following a five-day history of fluctuating fever. Physical examination revealed a soporific state with a Glasgow Coma Scale of E4V1M1. Initial non-contrast computed tomography of the head was unremarkable. Cerebrospinal fluid analysis demonstrated a mononuclear pleocytosis. Despite the lack of polymerase chain reaction confirmation and the absence of advanced electrophysiological monitoring, the patient was empirically diagnosed with herpes simplex encephalitis based on clinical deterioration and cerebrospinal fluid findings. Immediate management included intravenous acyclovir, dexamethasone, phenobarbital, and supportive care. The patient demonstrated significant clinical improvement and was discharged on day 24 without severe immediate neurological deficits. Conclusion: The absence of molecular diagnostics and advanced neuro-monitoring must not delay the administration of intravenous acyclovir in pediatric patients exhibiting fever and altered mental status. Empirical antiviral intervention remains the most critical determinant of survival and neurological recovery.
Navigating Diagnostic Constraints in Pediatric Herpes Simplex Encephalitis: Successful Empirical Acyclovir Therapy without PCR Confirmation I Kadek Putra Dwipayana; Romy Windiyanto
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 5 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i5.1596

Abstract

Background: Herpes simplex encephalitis is an acute or subacute disease associated with focal or global cerebral dysfunction caused by herpes simplex virus type 1 or type 2. Without adequate antiviral administration, the mortality rate reaches 70 percent, with only 9 percent of survivors returning to normal function. While cerebrospinal fluid polymerase chain reaction testing is the gold standard for diagnosis, its availability is severely restricted in resource-limited clinical environments. Case presentation: We report the case of a 4-year-old girl who presented with a profoundly decreased level of consciousness following a five-day history of fluctuating fever. Physical examination revealed a soporific state with a Glasgow Coma Scale of E4V1M1. Initial non-contrast computed tomography of the head was unremarkable. Cerebrospinal fluid analysis demonstrated a mononuclear pleocytosis. Despite the lack of polymerase chain reaction confirmation and the absence of advanced electrophysiological monitoring, the patient was empirically diagnosed with herpes simplex encephalitis based on clinical deterioration and cerebrospinal fluid findings. Immediate management included intravenous acyclovir, dexamethasone, phenobarbital, and supportive care. The patient demonstrated significant clinical improvement and was discharged on day 24 without severe immediate neurological deficits. Conclusion: The absence of molecular diagnostics and advanced neuro-monitoring must not delay the administration of intravenous acyclovir in pediatric patients exhibiting fever and altered mental status. Empirical antiviral intervention remains the most critical determinant of survival and neurological recovery.
Co-Authors Kadek Adi Sudarmika Putu Oky Ari Tania Romy Windiyanto