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R.H.Yudono R.H.Yudono
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Reduction of aspirin bioavailability by cimetidine R.H.Yudono, R.H.Yudono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 16, No 04 (1984)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (176.534 KB)

Abstract

The effect of cimetidine on the oral bioavailability of aspirin has been investigated in seven healthy adult volunteers. The estimation of bioavailability was performed by calculating the amount of the total salicylate recovered in the 72 hour urinary sample following an oral aspirin dose of 500 mg, first during control and second after pretreatment with oral cimetidine (RlUlcedin) 400 mg single dose given one hour prior to the administration of aspirin.The bioavailability of aspirin after cimetidine (36.5% ± SEM 4,2%) was significantly (paired. t-test, P
The features of anaphylactic shock in Yogyakarta, Indonesia R.H.Yudono, R.H.Yudono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 15, No 02 (1983)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (394.211 KB)

Abstract

An anaphylactic shock survey was carried out in Yogyakarta, Indonesia, during November December 1981. Physicians whith private practice were asked to complete the questionnaires given by the author. These questionnaires were collected without physicians identities.One hundred out of 135 respondents have had 270 patients suffering from anaphylactic shock accident. Two hundred and sixty one (96.7%) out of 270 patients had good recovery and 9 patients (3.3%) were dead. Preconditioning disturbances which made the therapy of these shocks difficult occurred in 27 patients (10 %).The drugs which caused these shocks were penicilline (27.8%). streptomycin (20%), penicilline streptomycin combination (14%), and others (38.2%). It was revealed that the route of administration of those drugs were intramuscular injection (97.4%), intravenous injection (1.1%), subcutaneous injection (1.1%). and oral administration (0.4%).Initial treatment of these shocks done by the physicians were intramuscular epinephrine (53%), intramuscular corticosteroid (23.7%), intramuscular antihistamine (15.9%), and intramuscular el-feud (1.5%). Two patients (0.7%) were immediately referred to the hospital without initial treatment given by the physicians. The rest (5.2%) had nonspecific treatment.Key Words: anaphylactic shock - allergen - penicillin - hypersensitivety - initial drug therapy
Mekanisme kerja beberapa pestisida dan penanggulangan keracunannya pada manusia R.H.Yudono, R.H.Yudono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 10, No 01 (1978)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (623.517 KB)

Abstract

Although the pesticides are for the purpose of killing pest ( = unwanted forms of life), they are also toxic to many non target species, including man. In fact acute or chronic poisoning by pesticides does occur. This is usually the result of occupational exposures or careless use, misuse or mishandling of the pesticides.As with the use of any potentially injurious chemical substance, the use of pesticides must take into consideration the balance of the benefits that may be expected versus the possible risk of injury to human health or to degradation of environmental quality.The prospect of mass starvation due to destruction of food crops by insects and noxious weeds compared to the question of possible injury to a few members of the population as a result of the use of insecticides may clearly indicate an advantage of pesticide use in terms of numbers of people whose health and welfare are protected. Similarly where vector borne diseases are a major threat to the health of large human populations and where the use of chemical pesticides to destroy the vectors of these diseases is a successful procedure, the application of these chemicals seems to beclearly indicated.For some groups of pesticides the mechanism of toxic action is well understood, but for others there is little or essentially no information concerning the way of intoxication.Concerning treatment, as might be expected from the current knowledge of pathogenesis, it is also not always easy CO find the right one. For this reason, if possible, we should better prevent than treat intoxication from pesticides or if we are forced to use pesticides, we must make our choice among the non-toxic pesticides or which intoxication is treatable.
Reduction of aspirin bioavailability by cimetidine R.H.Yudono R.H.Yudono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 16, No 04 (1984)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (176.534 KB)

Abstract

The effect of cimetidine on the oral bioavailability of aspirin has been investigated in seven healthy adult volunteers. The estimation of bioavailability was performed by calculating the amount of the total salicylate recovered in the 72 hour urinary sample following an oral aspirin dose of 500 mg, first during control and second after pretreatment with oral cimetidine (RlUlcedin) 400 mg single dose given one hour prior to the administration of aspirin.The bioavailability of aspirin after cimetidine (36.5% ± SEM 4,2%) was significantly (paired. t-test, P
The features of anaphylactic shock in Yogyakarta, Indonesia R.H.Yudono R.H.Yudono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 15, No 02 (1983)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (394.211 KB)

Abstract

An anaphylactic shock survey was carried out in Yogyakarta, Indonesia, during November December 1981. Physicians whith private practice were asked to complete the questionnaires given by the author. These questionnaires were collected without physician's identities.One hundred out of 135 respondents have had 270 patients suffering from anaphylactic shock accident. Two hundred and sixty one (96.7%) out of 270 patients had good recovery and 9 patients (3.3%) were dead. Preconditioning disturbances which made the therapy of these shocks difficult occurred in 27 patients (10 %).The drugs which caused these shocks were penicilline (27.8%). streptomycin (20%), penicilline streptomycin combination (14%), and others (38.2%). It was revealed that the route of administration of those drugs were intramuscular injection (97.4%), intravenous injection (1.1%), subcutaneous injection (1.1%). and oral administration (0.4%).Initial treatment of these shocks done by the physicians were intramuscular epinephrine (53%), intramuscular corticosteroid (23.7%), intramuscular antihistamine (15.9%), and intramuscular el-feud (1.5%). Two patients (0.7%) were immediately referred to the hospital without initial treatment given by the physicians. The rest (5.2%) had nonspecific treatment.Key Words: anaphylactic shock - allergen - penicillin - hypersensitivety - initial drug therapy
Mekanisme kerja beberapa pestisida dan penanggulangan keracunannya pada manusia R.H.Yudono R.H.Yudono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 10, No 01 (1978)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (623.517 KB)

Abstract

Although the pesticides are for the purpose of killing pest ( = unwanted forms of life), they are also toxic to many non target species, including man. In fact acute or chronic poisoning by pesticides does occur. This is usually the result of occupational exposures or careless use, misuse or mishandling of the pesticides.As with the use of any potentially injurious chemical substance, the use of pesticides must take into consideration the balance of the benefits that may be expected versus the possible risk of injury to human health or to degradation of environmental quality.The prospect of mass starvation due to destruction of food crops by insects and noxious weeds compared to the question of possible injury to a few members of the population as a result of the use of insecticides may clearly indicate an advantage of pesticide use in terms of numbers of people whose health and welfare are protected. Similarly where vector borne diseases are a major threat to the health of large human populations and where the use of chemical pesticides to destroy the vectors of these diseases is a successful procedure, the application of these chemicals seems to beclearly indicated.For some groups of pesticides the mechanism of toxic action is well understood, but for others there is little or essentially no information concerning the way of intoxication.Concerning treatment, as might be expected from the current knowledge of pathogenesis, it is also not always easy CO find the right one. For this reason, if possible, we should better prevent than treat intoxication from pesticides or if we are forced to use pesticides, we must make our choice among the non-toxic pesticides or which intoxication is treatable.
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