Article Per Year (5 Year)
p-Index From 2020 - 2025
0
P-Index
This Author published in this journals
All Journal Medical Journal of Indonesia Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia)
I. A. Rachman
Unknown Affiliation
Health Professions Medicine & Pharmacology Public Health

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
The influence of exposure to UVβ of fluorescent light on the bone remodeling of hypoestrogenic Macaca fascicularis Rachman, I. A.
Medical Journal of Indonesia Vol 10, No 2 (2001): April-June
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (551.279 KB) | DOI: 10.13181/mji.v10i2.10

Abstract

The prevention of osteoporosis is a spesific problem that should be dealt with by increasing the womens lift expectation. The decrease of calcitriol and estrogen levels, which have a receptor in the osteoblast, will result in bone mineralization (due to calcitriol) and the information of type 1 collagen (due to estrogen). The formation of calcitriol with the main basic materials from vitamin D3 is achieved with the aid of sunray UVβ, The changes in the lifestyle of women, which make them now accustomed to performing indoor activities and prevent them from being exposed to UVβ all day, have resulted in the decrease of vitamin D3 in calcitriol in women. In addition, when entering the menopausal age they will be threatened with early osteoporosis. The exposure to the UVβ of fluorescent light with the wave length identical to sun of 290-320 nm has long been known as a modality for treating skin diseases in the hope that the production of vitamin D3  will be increased. We exposed Macaca fascicularis, whose estrogen levels were set at normal, beginning low, beginning very low levels, to UVβ of fluorescent light. It showed that the Macaca fascicularis that were exposed to UVβ experienced an increase in osteocalcin with unchanged DPD which means that bone remodeling remains unchanged. By contrast, Macaca fascicularis with normal, beginning low, and beginning very low estrogen levels which were not exposed to UVβ were found to experience a decrease in osteocalcin and unchanged DPD levels. This means that a change has occurred in the bone remodeling toward bone resorption. (Med J Indones 2001; 10: 63-8)Keywords: UVβ, osteoporosis, estrogen, vitamin D3, calcitriol, osteocalcin, DPD
Pengaruh Isoflavon Terhadap Profil Lipid pada Perempuan Menopause/pascamenopause LASMINI, P. S.; HESTIANTORO, A.; RACHMAN, I. A.
Indonesian Journal of Obstetrics and Gynecology Volume. 30, No. 3, July 2006
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (301.261 KB)

Abstract

Tujuan: Untuk menentukan efek perubahan profil lipid pada perempuan menopause/pascamenopause yang diberi fitoestrogen (isoflavon). Tempat: Poliklinik Menopause RSCM/FKUI Jakarta. Rancangan/rumusan data: Uji klinis cara tersamar ganda dengan desain paralel tanpa matching. Bahan dan cara kerja: Selama kurun waktu April 2005 - September 2005, terkumpul 48 orang perempuan menopause/pascamenopause berusia < 65 tahun yang sehat, telah mengalami henti haid minimal selama 1 tahun dengan kadar FSH ≥ 30 mIU/L. Setelah dilakukan randomisasi sederhana dengan tabel random dan tersamar ganda, subjek penelitian dibagi dua kelompok, kelompok pertama diberi obat fitoestrogen isoflavon oral 100 mg/hari (2 x 50 mg), kelompok kedua diberi plasebo oral. Sebelum minum obat, diperiksa kadar lipid serum berupa kolesterol total, LDL kolesterol, HDL kolesterol dan trigliserida. Pemeriksaan kadar lipid serum kedua diperiksa setelah minum obat selama 12 minggu untuk melihat perubahan profil lipid setelah minum obat. Hasil: Dari 48 orang yang ikut penelitian, 2 orang dikeluarkan dari penelitian. Ditemukan kenaikan rerata kadar kolesterol total serum setelah 12 minggu pada kelompok obat sebesar -17,21 mg/dl (8,1%), tetapi secara statistik tidak bermakna. Pada kelompok plasebo sebesar -33,04 mg/dl (15%), secara statistik tidak bermakna. Pada kelompok obat ditemukan kenaikan kadar LDL sebesar -20,43 mg/dl, lebih sedikit dibanding kelompok plasebo sebesar -30,92 dan secara statistik bermakna setelah minum obat. Ditemukan penurunan kadar rerata HDL sebesar 3,99 mg/dl, secara statistik tidak bermakna pada kelompok obat setelah 12 minggu. Pada kelompok plasebo ditemukan kenaikan sebesar 1,40 dan tidak bermakna secara statistik. Pada kedua kelompok obat dan plasebo terdapat kenaikan rerata kadar trigliserida (secara statistik tidak bermakna) yaitu berturut-turut sebesar 3,54 mg/dl dan 4,16 mg/dl. Kesimpulan: Tidak ditemukan perubahan profil lipid pada pemberian isoflavon 100 mg/hari selama 12 minggu pada perempuan menopause/ pascamenopause yang sehat. [Maj Obstet Ginekol Indones 2006; 30-3: 156-63] Kata kunci: profil lipid, perempuan menopause/pascamenopause, isoflavon.
Co-Authors HESTIANTORO, A. LASMINI, P. S.