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Kisrini Kisrini

Faculty of Medicine, Sebelas Maret University

Author-ID : 3552577

Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Immunology & microbiology Medicine & Pharmacology

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Pengaruh Fraksi Air Ekstrak Etanol Umbi Bawang Merah (Allium cepa L.) terhadap Kadar Kolesterol Total Serum Darah Tikus Putih Erna Dwi Hastutik; Kisrini Kisrini; Dwi Ningsih
Jurnal Farmasi Indonesia Vol 7 No 1 (2010): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Onion (Allium cepa L.) is one of medical plants that widely used, and onion tuber is supposed to have beneficial to decrease cholesterol level. The aim of this study was to find out the effect of water fraction of onion ethanol extract that given orally on decreasing total cholesterol level in blood serum of white rats wistar and to see the dose that gave the effect equal with simvastatin in decreasing total cholesterol level. The study to determine cholesterol level of the animal testing was conducted by CHOD-PAP method. Test animals were divided into 5 groups and each group consists of 5 rats. Group I as negative control was contain CMC 1%. Group II was contain CMC 1% and treated water fraction of onion etanol extracts with three variations of dose, namely 25, 50, 100 mg/200 g body wight obtained from the ethanol extract fraksinasi using water and ethyl acetate. Group III as positive control was contain simvastatin and CMC 1%. Test animals were given pig oil and cholesterol powder for one week until hypercholesterolemia condition, and then were given test preparation until the 14th day. The cholesterol level was measured on the 1st, 7st and 14st day. The results of this study were that water fraction of onion ethanol extracts that given orally could decrease total cholesterol level in blood serum of white male rat. According to the results of one way anova statistical test, it was indicated that water fraction of onion ethanol extracts of 100 mg/ 200 g body wight dose had the effect to decrease total cholesterol level equal with simvastatin.

Evaluasi Penggunaan Obat Antihipertensi pada Pasien Geriatri Rawat Inap di RSUD Karanganyar dengan Metode ATC/DDD Ivonia Odi Seran; Kisrini Kisrini; Pudiastuti Pudiastuti
Jurnal Farmasi Indonesia Vol 11 No 1 (2014): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Hypertension is a major health problem most frequently found in Indonesia. This disease can affect anyone from various socio-economic groups. This study aimed to determine the drug utilization in terms of the drug classes, dosage form, drug administration route (pattern of antihypertensive drugs usage) in geriatric patients and its compliance with the Medical Care Standards (MCS) and the Hospital Formulary at Karanganyar Hospital in 2011 using the ATC / DDD methods, and determine antihypertensive drugs which include in DU90% segment. This study used secondary data which were taken from the patient's Medical Record. This research was quantitative descriptive research, the data were collected retrospectively. Data of antihypertensive utilization and inpatient visit obtained from Medical Record Installation. Entire data then were processed to determine the quantity of antihypertensive utilization in DDD/100 unit of inpatient day and Drug Utilization profile (DU90%). The results showed that the antihypertensive drugs utilization in geriatric patients (60 years and above) in Karanganyar Hospital during 2011 were captopril (60.69%), furosemide (11.26%), amlodipine (8.17%), nifedipine (9.45%), hirdroklorotiazid (5.94%), lisinopril (3.44%), bisoprolol (1.05%), and from the DU90% table, drugs which include in the DU90% segment were captopril, furosemide, and amlodipine. The compliance to Hospital Formulary in 2011 was 80%.

Uji Aktivitas Diuretik Ekstrak Etanol Kombinasi Daun Putri Malu (Mimosa pudica L.) dan Daun Pacar Kuku (Lawsonia inermis L.) pada Tikus Jantan Galur Wistar Dwi Novita Eka Sari; Fransiska Leviana; Kisrini Kisrini
Jurnal Farmasi Indonesia Vol 11 No 2 (2014): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Putri malu (Mimosa pudica L.) and pacar kuku (Laswonia inermis L.) leaves can be used as diuretic agent. This research aimed to find out the diuretic effect of combination of putri malu and pacar kuku leaves ethanol extract as the effective dose on Wistar male rat. The tested animal used consisted of 35 rats, divided into 7 groups: furosemida positive control (1,44 mg/200 g BW), negative control CMC 0.5%, extract of putri malu leaves (20 mg/200 g BW), extract of pacar kuku leaves (50 mg/200 g BW), combination of putri malu and pacar kuku leaves ethanol extract (10 : 25 mg/200 g BW; 5 : 37,5 mg/200 g BW; 15 : 12,5 mg/200 g BW). Observation was conducted every hour for 6 hours, and then at 12 and 24 hours. The diuretic effect was obtained by estimating cumulative urine volume and AUC (Area Under The Curve). The data was processed using oneway variance analysis followed by Tukey HSD test. The result of research the combination of putri malu and pacar kuku leaves ethanol extract has a diuretic effect. The extract combination had diuretic effect higher than the single extract. The combination of putri malu and pacar kuku leaves ethanol extract dose of 5 mg/200 g BW : 37,5 mg/200 g BW and 15 mg/200 g BW : 12,5 mg/200 g BB had diuretic activity compatible to the positive control.

Uji Kepekaan Bakteri Klebsiella sp. Hasil Isolasi Ulkus Diabetes Pasien Rawat Inap Di RSUD Dr. Moewardi terhadap Antibiotik Meropenem, Gentamisin, Seftriakson, dan Siprofloksasin pada Bulan Februari-Maret Tahun 2014 Ima Fatimah; Kisrini Kisrini; D. Andang Arif Wibowo
Jurnal Farmasi Indonesia Vol 12 No 1 (2015): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Diabetic ulcer is an open wound on the surface of the skin caused by macroangiopati so insufisiensi and vascular neuropathy, diabetic ulcer, if not immediately get treatment and care, it will be easy to make the infection extends and immediately in case of any further action requiredamputation. The purpose of this study was to isolate Klebsiella sp. isolation of sufferers of diabetes ulcer purulence inpatients in RSUD Dr. Moewardi and knowing the pattern of sensitivity antibiotics gentamicin, seftriakson, meropenem, ciprofloxacin and against bacteria Klebsiella sp. in February-March 2014. Purulence samples obtained was isolated on media Mac Conkey, continued staining grams and biochemistry test. Antibiotic sensitivity test refers to the standard Kirby Bauer, to analyze the data using Oneway ANOVA. The study is done against 30 samples purulence patients ulcer diabetes in RSUD Dr. Moewardi February-March 2014, 18 positive samples containing Klebsiella sp. and 12 negative samples Klebsiella sp. antibiotic meropenem 100% sensitive, sensitive 100% ciprofloxacin, gentamicin resistant 96,29% and 3,71% intermediate, seftriakson 94,50% resistant and 5,50% moderately suspectible.

Co-Authors D. Andang Arif Wibowo Dwi Ningsih Dwi Novita Eka Sari Erna Dwi Hastutik Fransiska Leviana Ima Fatimah Ivonia Odi Seran Pudiastuti Pudiastuti

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