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Rika Widyapranata
Faculty of Pharmacy, Setia Budi University
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Immunology & microbiology Medicine & Pharmacology

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Penggunaan Basis Salep Ekstrak Etanolik Biji Mahkota Dewa (Phaleria macrocarpa ) Sebagai Anti Bakteri Terhadap Staphylococcus aureus ATCC 25923 Rika Widyapranata
Jurnal Farmasi Indonesia Vol 8 No 2 (2011): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (84.608 KB) | DOI: 10.31001/jfi.v8i2.42

Abstract

Mahkota dewa (Phaleria macrocarpa (Scheff) Boerl) belongs to the family of Thymelaeaceae, the seed contains flavonoid, tannin and alkaloid. Extraction was carried out by means of a soxhlet. The objectives of this experiment were to study the antibacterial activity of mahkota dewa seed extract, to select the best ointment base and the effective concentration of the seed extract of the ointment. Antibacterial activity of the ethanolic seed extract of mahkota dewa was tested by diffusion method and formulated into hydrocarbon, absorption, emulsion and water soluble ointment base each containing 3% of the seed extract to determine the best ointment base. Ointment with water soluble base (the best among above mentioned ointment base) with an extract concentration of 2%, 3%, 4% and 5% were made and applied to the infected area twice daily and observations made until the wound has dried. Topical ointment with 1% Gentamycin was used as positive control. Result of the experiment showed that ethanolic seed extract of mahkota dewa and the ointments with the above mentioned four concentrations have an antibacterial activity against Staphylococcus aureus ATCC 25923 indicated by the disappearance of the pus and healing of the wound. Ointment of water soluble base with 4% seed extract of mahkota dewa has the most effective antibacterial property.
Formulasi Ekstrak Buah Jambu Biji (Psidium guajava L.) sebagai Lotion Antioksidan Ayu Sri Bulan; Lina Susanti; Rika Widyapranata
Jurnal Farmasi Indonesia Vol 11 No 1 (2014): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (887.08 KB) | DOI: 10.31001/jfi.v11i1.53

Abstract

White guava (Psidium guajava, L.) fruit extract has antioxidant activity, because it contains quercetin, a flavonoid compound. Lotion is cosmetic preparations that widely used. This research was aimed to find out the antioxidant activity of lotion of white guava fruit extract. The white guava extract was made lotion preparation in three different concentrations of 18,5%; 20,5%, dan 22,5%. The three formulas were tested for its dispersive, adhesion, and viscosity. Determination of antioxidant activity in lotion was conducted by DPPH (1,1-diphenyl-2 pikrilhidrazil) using rutin as control and the results were calculated by IC50 value by probit analysis. The results showed that guava fruit extract lotion had antioxidant activity. Formula with the highest antioxidant activity was formula contained white guava fruit extract concentration of 22.5% with IC50 value of 131.83 ppm.
Co-Authors Ayu Sri Bulan Lina Susanti