Garuda - Garba Rujukan Digital

Supriyadi Supriyadi

Faculty of Pharmacy, Setia Budi University

Author-ID : 3552638

Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Immunology & microbiology Medicine & Pharmacology

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Identifikasi Steviosida pada Kalus Daun Stevia yang Ditumbuhkan dengan 2,4-D dan Kinetin Kartinah Wiryosoendjoyo; Supriyadi Supriyadi
Jurnal Farmasi Indonesia Vol 11 No 1 (2014): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Stevia leaves are harvested because of their sweetness. This special characteristic is contributed by steviosida, rebaudiosida and dulkosida. Steviosida and rebaudiosida are low calorie, not able to be fermented by bacteria in the mouth and non carcinogenic. These superiorities make steviosida able to act as sugar subtitute, especially for diabetics; obese and as sweetener for toothpaste. The aim of this research was to find planting medium of Stevia leaf explants which is capable of producing the highest level of stevioside. The explants were grown in Surakarta. The medium was New Phaleonopsis (NP) within the addition of growth regulator substance, the combination of 2,4 Dichlorophenoxyacetic Acid (2.4-D), and Furfuril Amino Purin (kinetin) each by kinetin 1 ppm; 2,4-D 0.25 ppm and kinetin 0,75 ppm; 2,4-D 0,5 ppm as well as kinetin 0,5 ppm; 2,4-D 0,75 ppm and kinetin 0,25 ppm 2,4-D 1 ppm. Callus levels were macerated by n-butanol, then were analyzed by TLC densitometry. Stevioside levels in callus were compared with the steviosid levels in the original plants. The highest stevioside level was found in the callus grown in NP medium by adding 1 ppm kinetin, amounting to 10,625 ppm. The steviosid level was higher than the original plants. Stevioside level in Stevia leaf was 0,65 ppm.

Preclinic Activity Test of Capsule of Natural Ingredients Extract Combination of Noni Fruit (Morinda citrifolia L.) and Papaya Leaf (Carica papaya L.) as Hepatoprotector Agent for Tuberculosis (TB) Treatment Ilham Kuncahyo; Supriyadi Supriyadi
Jurnal Farmasi Indonesia Vol 11 No 2 (2014): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Research has been conducted in year 1st with the manufacture capsule of noni fruit (Morinda citrifolia L.) and papaya leaf (Carica papaya L.) as the active material to cope with damage to the liver (hepatoprotective) for the treatment of tuberculosis (TB). Year 2nd pre-clinical tests have been conducted using rats as test animals given INH and rifampicin that are often used in the treatment of tuberculosis for 28 days. Test animals consisted of 30 rats were grouped into six groups. Group I (normal control) were without any treatment, rat were given only the usual food and drink. Group II (negative control) were given INH-rifampicin suspension (INH dose of 10 mg/200 g BW and rifampicin dose of 10 mg/200 g BW. Group III (positive control) were given INH-rifampicin suspension and drug antihepatotoxic methicolÂ®. Group IV were given formula capsule 1, group V were given formula capsule 2, and group VI were given formula capsule 3. Parameters of liver damage was observed by measuring the levels of serum bilirubin, ALT and AST values. The parameters were measured on day 0 (before treatment), day 14, day 21, and day 28. There were observed liver histologically by histological methods-microscopic photograph using hematoxylin eosin staining. The data obtained were statistically evaluated using ANOVA one way for percentage of liver necrosis and two-way ANOVA for ALT, AST and serum bilirubin, with a 95% confidence level. The results showed that the formula capsule 1 of extract combination of papaya leaf and noni fruit with PVP binder 1 % was able to provide reduced liver damage on rats induced isoniazidrifampicin which was better than formula capsule 2 and 3.

Pengaruh Pemberian Ekstrak Etanolik Daun Pandan Wangi (Pandanus amaryllifolius Roxb.) Terhadap Kadar Enzim Alp Pada Tikus Putih Yang Diinduksi Isoniazid Dan Rifampisin Angga Adi Rahmawan; Supriyadi Supriyadi; Tri Wijayanti
Jurnal Farmasi Indonesia Vol 13 No 1 (2016): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Pandan leaves are medicinal plants that contain alkaloids, saponins, flavonoids, tanins and poliphenols compounds that have high antioxidant activity and potential as hepatoprotective. This research was conducted to determine the effect of ethanol extract pandan leaves (Pandanus amaryllifolius Roxb.) on the rate of ALP in to determine potency extract ethanol pandan leave inhibit necrosis cell of liver in white rats isoniazid and rifampisin induced. This research was used thirty rats were divided in 6 groups. Group I as a normal group. Group II as a hepatotoxic group. Group III as a drug group was given Curcuma 3,6 mg/200 g BW. Group IV, V, and VI as the treatment group given test solution ethanol extract pandan leaves 8,64 mg/200 g BW, 17,28 mg/200 g BW and 25,92 mg/200 g BW for 28 days. All groups except group I were induced by isoniazid and rifampisin 10,8 mg/200 g BW. All groups on day 0, 14th and 28th set ALP rate. Results obtained were analyzed by One Way ANOVA test. The results showed that ethanol extract pandan leaves at a dose of 8,64 mg/200 g BW, 17,18 mg/200 g BW, and 25,92 mg/200 g BW can inhibit ALP in to determine potency ethanol extract pandan leave inhibit necrosis cell of liver in white rats isoniazid and rifampisin induced. Dose of the ethanol extract pandan leaves was the most effective is 25,92 mg/200 g BW.

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