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Lina Susanti
Faculty of Pharmacy, Setia Budi University
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Immunology & microbiology Medicine & Pharmacology

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Formulasi Ekstrak Buah Jambu Biji (Psidium guajava L.) sebagai Lotion Antioksidan Ayu Sri Bulan; Lina Susanti; Rika Widyapranata
Jurnal Farmasi Indonesia Vol 11 No 1 (2014): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (887.08 KB) | DOI: 10.31001/jfi.v11i1.53

Abstract

White guava (Psidium guajava, L.) fruit extract has antioxidant activity, because it contains quercetin, a flavonoid compound. Lotion is cosmetic preparations that widely used. This research was aimed to find out the antioxidant activity of lotion of white guava fruit extract. The white guava extract was made lotion preparation in three different concentrations of 18,5%; 20,5%, dan 22,5%. The three formulas were tested for its dispersive, adhesion, and viscosity. Determination of antioxidant activity in lotion was conducted by DPPH (1,1-diphenyl-2 pikrilhidrazil) using rutin as control and the results were calculated by IC50 value by probit analysis. The results showed that guava fruit extract lotion had antioxidant activity. Formula with the highest antioxidant activity was formula contained white guava fruit extract concentration of 22.5% with IC50 value of 131.83 ppm.
Efek Perasan Kering Kulit Nanas (Ananas comosus (L.) Merr) terhadap Waktu Perdarahan dan Pembekuan Darah pada Tikus Putih Jantan Veronica Bella Lupita; Opstaria Saptarini; Lina Susanti
Jurnal Farmasi Indonesia Vol 12 No 1 (2015): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (533.373 KB) | DOI: 10.31001/jfi.v12i1.78

Abstract

Pineapple has a peel that contains bromelain enzyme which is useful as platelet antiagregation. This study was aimed to determine the effect of pineapple peel dried juice on bleeding and clotting time extention, and to know the most effective dose in prolonging bleeding time and blood clotting. This study includes the determination of plants, drying of pineapple peel, the identification of the chemical contents, and test of bleeding and clotting time. This study used 5 treatment groups. The group was divided into treatment groups with pineapple peel dried juice variation dose of 28 mg/200 g BW, 56 mg/200 g BW, and 112 mg/200 g BW, positive control group (acetosal 3.7 mg/200 g BW), and negative control group (distilled water). The identification results showed chemical constituents of bromelain enzyme compounds, flavonoids, and saponins. The test results showed that platelets antiagregation freeze drying product from pineapple peel dried juice which was administered orally could prolong the bleeding time and blood clotting on white male rats. Pineapple peel dried juice with a dose of 112 mg/200 g BW gave the best effect to the extension of bleeding and clotting time with an average increase in bleeding time of 150seconds and an increase in clotting time of 105 seconds.
Co-Authors Ayu Sri Bulan Opstaria saptarini Rika Widyapranata Veronica Bella Lupita