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Muhammad Dzakwan
Faculty of Pharmacy, Setia Budi University
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Immunology & microbiology Medicine & Pharmacology

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Optimasi Formula Tablet Lepas Lambat Tramadol HCl dengan Kombinasi Matriks Mukoadhesif PVP dan Xanthan Gum secara Simplex Lattice Design Chaesti Setyo Hastuti; Ilham Kuncahyo; Muhammad Dzakwan
Jurnal Farmasi Indonesia Vol 11 No 1 (2014): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (902.073 KB) | DOI: 10.31001/jfi.v11i1.59

Abstract

Tramadol HCl is a synthetic opioid of cyclohexanol group which acts as an analgesic. To improve the comfort and compliance of patient, therefore tramadol HCl is made in sustained release tablet. In this study, sustained release tablet of tramadol HCl was combined with PVP and xanthan gum mucoadhesive matrix. This study was made in four formulas, they were: control formula (without the matrix), F I (25% PVP : 75% xanthan gum), F II (50% PVP : 50% xanthan gum), and F III (75% PVP : 25% xanthan gum). The tablets were made by dry granulation and compressed to 250 mg weight of tablet. The obtained granules and tablets were tested for the physical properties. The properties determination of the optimum formula used Simplex Lattice Design method (SLD) with Software Design Expert 8.0.6. The parameters used were: flowing time, hardness, friability, and disolution. The experimental results and the theoretical optimum formula were analyzed using t-test. The optimum formula sustained release tablet of tramadol HCl with PVP and xanthan gum mucoadhesive matrix combination by Simplex Lattice Design was obtained in proportion of 55,031% PVP and 44,969% xanthan gum. Pattern of tramadol HCl release on the optimum formula followed diffusion mechanism and zerro orde kinetic. The response of physical properties of optimum formula was obtained from prediction result and examination showed that there was not different significant.
Uji Aktivitas Diuretik Ekstrak Daun Matoa (Pometia pinnata) pada Tikus Jantan Galur Wistar Ika Purwidyaningrum; Muhammad Dzakwan
Jurnal Farmasi Indonesia Vol 12 No 1 (2015): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (303.242 KB) | DOI: 10.31001/jfi.v12i1.81

Abstract

Matoa leaves (Pometia pinnata) empirically were used as antihypertensive. Diuretic medicine correlated with antihypertensive drugs so this study aims to determine the effect of diuretics matoa leaves extract. Matoa leaves ethanol extract was tested on male rats wistar strain. Animal tests used as many as 25 tails were divided into 5 groups, namely: negative control CMC 0.5%, furosemide 3.6 mg/kg, matoa leaves ethanol extract 50 mg/kg, matoa leaves ethanol extract 100 mg/kg BB, matoa leaves ethanol extract 150 mg/kg. Then the hour urine volume is recorded at 1, 2, 3, 4, 5 and 24 hours. Diuretic effect can be seen from the analysis of data obtained diuretic percent of the volume of urine each time of observation. Results of this research was conducted matoa leaves extract diuretic test. Based on data and ANOVA test can be concluded that the ethanol extract of the matoa leaves can efficacious as a diuretic and its effective dose is 100 mg/kg.
Pengembangan dan Evaluasi Formulasi dari Tablet Kunyah Nanopartikel Mebendazol Muhammad Dzakwan; Widodo Priyanto
Jurnal Farmasi Indonesia Vol 13 No 1 (2016): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (80.836 KB) | DOI: 10.31001/jfi.v13i1.98

Abstract

Mebendazole is a benzimidazole derivative with broad spectrum anthelminthic activity and excellent tolerability. Orally it is rapidly absorbed and metabolized to sulfoxide and sulfone, which may be responsible for its anthelminthic action. This research aimed to formulate mebendazole nanoparticle chewable tablet to increase its dissolution velocity and impact saturation solubility. Mebendazole nanoparticle chewable tablets (300 mg) were prepared by direct compression. The tablets prepared by this method were evaluated by different parameters such as average weight, hardness, friability, disintegration, drug content and in vitro dissolution etc. All the parameters were found within the specifications. The study on the dissolution profile revealed that F1 had better dissolution rate while compared to F2, F3 and mebendazole microparticle, respectively. Assay values were within the limits of 90% to 110%.
Co-Authors Chaesti Setyo Hastuti Ika Purwidyaningrum Ilham Kuncahyo, Ilham Widodo Priyanto