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Ika Nur Fitriani
Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Negeri Islam Walisongo Semarang
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Immunology & microbiology Medicine & Pharmacology

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Efek Reaksi Isomerisasi Pada Miristisin Terhadap Potensinya Sebagai Tabir Surya Secara in-vitro Hery Muhamad Ansory; Ika Nur Fitriani
Jurnal Farmasi Indonesia Vol 18 No 1 (2021): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v18i1.1094

Abstract

Myristicin has an alkenyl benzene structure with a double bond that is not conjugated with a benzene ring with good sunscreen activity, the change of the double bond to the conjugated position can be done by an isomerization reaction. This change will result in the molecule having longer delocalized double bonds and is expected to increase its activity as a sunscreen. The purpose of this study was to see the effect of changes in myristicin structure on its activity as a sunscreen. The isomerization reaction was carried out by reflux method using 20% ​​KOH catalyst in ethanol for 5 hours. Sunscreen activity test was carried out in-vitro using a UV spectrophotometer. The results of the isomerization reaction obtained isomyristicin in the form of a clear light yellow liquid that dissolves in ethanol (1: 1) with a% yield of 84% and a purity of 90% E: Z (6: 1). The results of the sunscreen activity test showed changes that were not much different between myristicin and isomyristicin, which indicated that the isomerization reaction had no significant effect on sunscreen activity.
Co-Authors Muhamad Ansory, Hery