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All Journal Jurnal Online Mahasiswa (JOM) Bidang Kedokteran The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Rum Affida Rasfa
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Medicine & Pharmacology

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UJI DIAGNOSTIK PEMERIKSAAN C-REAKTIF PROTEIN (CRP) PADA NEONATUS TERSANGKA SEPSIS YANG DIRAWAT DI INSTALASI NEONATUS RSUD ARIFIN ACHMAD PROVINSI RIAU Rum Affida Rasfa; Nazardi Oyong; Fatmawati "
Jurnal Online Mahasiswa (JOM) Bidang Kedokteran Vol 2, No 2 (2015): Wisuda Oktober 2015
Publisher : Jurnal Online Mahasiswa (JOM) Bidang Kedokteran

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Abstract

Neonatal sepsis is a collection of clinical symptoms and laboratory associated with infection due to the invasion of microorganisms during the first 28 days of a child's life time. The certain diagnosis of neonatal sepsis is the isolation of bacteria from blood or body fluids. However, this method takes at least 72 hours. Therefore, It is necessary an investigation with a relatively short time. One of methods is C-Reactive Protein (CRP) examination. Even though CRP examination has been done in many of diagnosis of sepsis,however this examination also has some limitations. This research designusing a diagnostic test with retrospective approach. The sampling technique is performed by consecutive sampling method and amount of sample is 313 people. The results showed that the characteristics of the neonatal sepsis suspect in accordance with age is early neonatal (0-6 h), which amount to 235 (75%), and majority is male by 182 (58%). The most risk factor for gestational age <37 weeks is 133 samples with a median value is 11.4 mg / dl. Late Onset Neonatal Sepsis (LONS) is the highest classification of sepsis group at 93 (82%) with a median value is 192 mg/dl. The diagnostic value of CRP examination are sensitivity 65.7%, specificity 79.3%, positive predictive value 64.6%, negative predictive value 80.2%, positive contingency ratio 3.25, negative contingency ratio 0.43 and accuracy of 74.4%. As the result, we obtain cut off the recommended point is ≥10,2 mg / dl.Keywords : sepsis, C-Reactive Protein (CRP), LONS
Clinicopathological Characteristics of Hepatocellular Carcinoma at a Tertiary Hospital: A Retrospective Study Rasfa, Rum Affida; Hilbertina, Noza; Asri, Aswiyanti; -, Yenita; Devianti, Loli
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 27, No 1 (2026): VOLUME 27, NUMBER 1, April, 2026
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/271202637-44

Abstract

Background: Hepatocellular carcinoma (HCC) is the sixth most common cancer globally and shows significant regional variations in clinicopathological characteristics. Limited data exist on HCC patterns in Indonesia, particularly in West Sumatra. This study aimed to characterize the clinicopathological features of HCC at Dr. M. Djamil Hospital, Padang, from 2021to2024.Methods: A descriptive retrospective study was conducted using medical records and histopathological re-evaluation of 46 HCC cases. Specimens were examined for demographic data, tumor characteristics, histopathological subtypes according to the WHO 2019 classification, differentiation grade, lymphovascular invasion, and background liver pathology.Results: The median age was 56 years, with male predominance (60.9%). Most specimens were resection specimens (60.9%) with tumor size ≥4 cm in 47.8% of cases and single nodules in 52.1%. Clear cell (39.1%) and macrotrabecular massive (37.0%) were the predominant subtypes, contrasting with global data showing NOS predominance. Most tumors were moderately differentiated (63.0%), with lymphovascular invasion present in 65.2% and cirrhotic background in 58.7% of casesConclusion: HCC in West Sumatra demonstrates distinct histopathological patterns, with a predominance of clear cell and macrotrabecular massive subtypes and high rates of lymphovascular invasion. These finding suggest histopathological features associated with aggressive tumor behavior (particularly macrotrabecular massive subtype and lymphovascular invasion), although no clinical outcome or survival analysis was performed.
Co-Authors -, Yenita Aswiyanti Asri Devianti, Loli Fatmawati " Nazardi Oyong Noza Hilbertina, Noza