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Ita Haryatie
Universitas Sebelas Maret
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The Delay in The Diagnosis of Lung Cancer Due to Misdiagnosis as Pulmonary Tuberculosis Jatu Aviani; Satria Maulana EH; Ita Haryatie; Farih Raharjo; Yusup Subagio Sutanto; Ana Rima Setijadi
Jurnal Respirologi Indonesia Vol 37, No 4 (2017)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (422.907 KB) | DOI: 10.36497/jri.v37i4.83

Abstract

Background: Lung cancer and pulmonary tuberculosis (TB) are global health problem. Similarity of symptoms of both made misdiagnose of lung cancer as TB and treated with Anti Tuberculosis Treatment (ATT). Evaluation of ATT often inaccurate, causing late diagnosis of lung cancer. This study aimed is to determine the lung cancer percentage with delayed diagnosis due giving of ATT for >1 month. Methods: A prospective descriptive study was performed from January 2014-February 2016 in Dr. Moewardi Hospital, Surakarta taken from the patient's medical record. Results: As much 293 patients with lung cancer consisted of 188 males (64.4%) and 105 females (35.8%) with the average age was 57 years old. The types of the lung cancer were non-small cell lung carcinoma (NSCLC) consisted of adenocarcinoma 195 subjects (66.6%), squamous cell carcinoma 65 subjects (22.2%), large cell carcinoma 23 subjects (7.8%) and neuroendocrine carcinoma 4 subjects (1.4%). The stages of the NSCLC were stage I (0%), II (0%), IIIa (0%), IIIb (11.7%) and IV (88.3%). Among 293 lung cancer patients, 89 subjects (30.4%) were diagnosis as pulmonary TB. Two subjects (2.2%) of 89 subjects were truly pulmonary TB while the rest 87 subjects were not pulmonary TB and had ATT for average 12 weeks with the longest period was 16 weeks. The ATT duration >1 month was 76.4%. Conclusions: Percentage of lung cancer patients with ATT before being referred to dr. Moewardi hospital were 30.4% of 293 lung cancer patients while 68 subjects (76.4%) of whom had received ATT >1 month. (J Respir Indo. 2017; 37(4): 288-92)
The Relationship of Interferon Gamma +874T/A and Interleukin-10 -1082G/A Gene Polymorphism to The Recovery of Multidrug Resistant Tuberculosis Patients Ita Haryatie; Harsini Harsini; Reviono Reviono
Jurnal Respirologi Indonesia Vol 37, No 4 (2017)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (551.503 KB) | DOI: 10.36497/jri.v37i4.85

Abstract

Background: Multidrug resistant (MDR) TB caused by the M.Tb strain is resistant toward at least rifampicin and isoniazid. Interferon Gamma is responsible for activating macrophages and phagocytosis for M.Tb destruction. Interleukin 10 causes a significant decrease in reactive nitrogen intermediates, increased arginase 1, and overall decreased macrophage function. Gene mutation causes IFN production by CD4 - T cells less effective and disrupts the immune response against M.Tb. There has been no research on the relationship between IFN-γ and IL-10 gene polymorphisms with TB recovery in Indonesia, especially in patients with MDR-TB. The aim of this study is to determine gene polymorphism relationship of IFN-γ +874T/A and IL-10 -1082G/A with MDR-TB recovery. Methods: This study was a non-experimental clinical trial with a retrospective cohort design. The study was conducted on 105 MDR-TB patients treated in dr. Moewardi Hospital between January 2011-June 2014 consists of 84 recovered patients and 21 patients died/failed. Results: Gene polymorphism of IFN-γ +874T/A was obtained OR=0.703 (0.265-1.863) and P=0.477 which mean IFN-γ +874 T/A gene was not related to recovered case of MDR-TB. The IL-10 -1082G/A gene obtained the value of OR=0.657 (0.173-2.491) and the value P=0.785 which means that IL-10 -1082G/A is not related to the MDR-TB case recovery. Conclusions: There is no relationship of IFN-γ + 874T/A and IL-10 -1082G/A gene polymorphisms in the recovery of MDR-TB patients. (J Respir Indo. 2017; 37(4): 299-306)
Co-Authors Ana Rima Setijadi Farih Raharjo Harsini Harsini Jatu Aviani Reviono Reviono Satria Maulana EH Yusup Subagio Sutanto