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All Journal Jurnal Respirologi Indonesia Respiratory Science
Ana Rima Setijadi
Universitas Sebelas Maret
Health Professions Medicine & Pharmacology

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Journal : Respiratory Science

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Concordance Rate Between Examination of EGFR Mutation Blood Plasma Sample (ctDNA) With Citological/Histopathological Sample in Adenocarcinoma Lung Cancer Dian Utami Wulaningrum; Ana Rima Setijadi; Suradi Suradi
Respiratory Science Vol. 1 No. 1 (2020): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v1i1.9

Abstract

Background: Most adenocarcinoma lung cancer which is found at an advanced stage with cytology / histopathological samples is hardly available. Examination of EGFR mutations in ctDNA blood plasma sampling is simpler and easier, which also can be used as predictive and prognostic markers in non-small cell carcinoma lung cancer patients. The purpose of this study is to determine and analyse the degree of compatibility between examination of EGFR mutations by blood plasma (ctDNA) samples with the examination of cytology / histopathological EGFR mutations in adenocarcinoma lung cancer. Methods: Diagnostic test research, by taking medical records of patients with adenocarcinoma lung cancer from January to September 2019 at Dr. Moewardi Surakarta, who was examined by EGFR mutations in cytology / histopathology and ctDNA samples. Result: The Subjects of this study were 73 patients with adenocarcinoma lung cancer. The level of compatibility of ctDNA with EGFR mutations in cytology / histopathology samples was categorized as moderate and statistically significant (Kappa = 0.459; p = 0.000). Conclusion: The level of concordance between the examination of EGFR mutations with blood plasma samples (ctDNA) with the examination of EGFR mutations in cytology / histopathology samples was moderate and statistically significant.
The Role of Incentive Spirometry On Exercise Capacity, Breathing Symptoms, Depression Rate, and Quality of Life in NSCLC Patients with Chemotherapy Dian Apriliana; Suradi Suradi; Ana Rima Setijadi
Respiratory Science Vol. 2 No. 1 (2021): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v2i1.33

Abstract

Backgrounds: Pulmonary rehabilitation is a non-pharmacological therapy that improves breathing capacity in lung cancer patients. This study aimed to determine the effects of incentive spirometry (IS) on exercise capacity, breathing symptoms, depression rates, and quality of life in lung cancer patients with chemotherapy. Method: This quasi-experimental study was done through purposive sampling of 32 lung cancer patients who underwent chemotherapy for at least three cycles at Dr. Moewardi General Regional Hospital, Surakarta, from December 2019 to February 2020.Data on 6 minutes walking test (6-MWT) to evaluate exercise capacity, breathing symptoms (BORG scale), level of depression (HRSD questionnaire), and quality of life (SGRQ questionnaire) . Results: Experimental group showed higher value of 6-MWT (72.75±152.50 meters vs. 31.81 ± 27.67, P=0.010), a decrease in the BORG scale (-1.78±1.72 vs. -0.38±1.67, P=0.013), Hamilton's score improvement (-2.25±5.12 vs. -4.25±5.34, P=0.075), and improvement in the SGRQ value (-10.77±9.82 vs. -0.08±11.16, P=0.752) compared to those of control group.
Co-Authors Dian Apriliana Dian Utami Wulaningrum Farih Raharjo Ita Haryatie Jatu Aviani Lydia Arista Sutedjo Muhammad Addinul Huda Reviono Reviono Satria Maulana EH Suradi Suradi Yusup Subagio Sutanto