Suradi Suradi
Universitas Sebelas Maret, RSUD Dr. Moewardi

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The Effect of Thymoquinone on Interleukin-8 Levels, %FEV1 and CAT Scores in Chronic Obstructive Pulmonary Disease Levana Kasumadewi; Suradi Suradi; Ana Rima Setijadi
Jurnal Respirologi Indonesia Vol 40, No 4 (2020)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v40i4.145

Abstract

Background: Chronic obstructive pulmonary disease (COPD) is a characterized by respiratory symptoms and persistent airway obstruction due to alveoli and/or airway abnormalities caused by continuous exposure to harmful particles or gases. Airway inflammation plays an important role in the pathogenesis of COPD. Nigella sativa, known as habbatusauda, contains thymoquinone, which has an anti-inflammatory effect. Airway inflamation improvement was measured based on decreased plasma IL-8 level, maintain the optimization of %FEV1 value and clinical improvement based on the decreased CAT score. Methods: The pretest and posttest experimental clinical trial was carried out in 40 patients with stable COPD in the pulmonology outpatient clinics of Dr. Moewardi Surakarta and dr. Soehadi Prijonegoro Sragen Hospital from 29 June to 3 August 2019. Subjects were grouped into treatment group (n=20) receiving standard therapy along with thymoquinone oil capsules 500 mg/day and placebo group (n=20) receiving standard therapy only for 30 days. Results: The study revealed statistically insignificant decreases of IL-8 level (P=0.052) and %FEV1 value (P=0.943) in the treatment group, while CAT score showed significant decreases in the treatment group (P=0.0005). Conclusion: Thymoquinone administration reduce inflammation as it can lower IL-8 level and improves the clinical condition of patients with stable COPD based on a decrease in CAT score.
Effect of Asthma Gymnastic on Blood Nitric Oxide, Mood, Energy Expenditure and Sex Quality Ita Juliastuti; Suradi Suradi; Debree Septiawan
Jurnal Respirologi Indonesia Vol 41, No 2 (2021)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v41i2.179

Abstract

Background: Sex is a basic function in human life. Exercise stimulates formation of blood nitric oxide (NO) as a potent vasodilator in all organs of the body including the genitals. Exercise prevents and improves depression and anxiety, but the link between exercise and sexual function has received less attention. Asthma gymnastic is an exercise in pulmonary rehabilitation that everyone can practice it. The effect of asthma gymnastic in sexology has never been studied yet. Methods: The pretest and posttest experimental clinical trials were carried out on 40 people aged 40-60 years old in Surakarta on 21st July 2019 until 27th October 2019. The intervention group (n=20) were treated with asthma gymnastics once a week for 12 weeks while the control group (n=20) didn’t exercise regularly. The aims of this study are to assess the effect of asthma gymnastic on blood nitric oxide, mood based on the Beck Depression Inventory (BDI) questionnaire, energy expenditure (physical and sexual activity) and sex quality based on the Arizona Sexual Experiences Scale (ASEX) questionnaire. Results: Asthma gymnastic had a significant positive effect on blood NO (B=0.426;P<0.003), physical activity (B=0.664;P<0.001) and sexual activity (B=0.336;P=0.026). Asthma gymnastic had a significant negative effect on the BDI score (B=-0.664;P<0.001). Asthma gymnastic did not have a direct effect on sex quality (B=-0.071;P=0.756). BDI score had a positive effect on sex quality (B=0.464;P=0.009). NO blood levels had no effect on sex quality (B=0.018;P=0.904). Conclusion: Asthma gymnastic had no direct effect on sex quality, but it increased blood NO, energy expenditure and improved mood. Asthma gymnastic would have significant effect on improving sex quality if supported by good mood.