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All Journal IJAAM (Indonesian Journal of Anti-Aging Medicine)
Nining Triyana Darise
Master Program in Biomedical Sciences Study Program Specificity of Anti-Aging Postgraduate Program Universitas Udayana Denpasar
Medicine & Pharmacology

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The 20% of petai seed (Parkia speciosa) extract cream in inhibited the increase of melanin counts in the skin of guinea pigs (Cavia porcellus) exposed to ultraviolet B Nining Triyana Darise; Wimpie Pangkahila; AAGP Wiraguna
IJAAM (Indonesian Journal of Anti-Aging Medicine) Vol 5 No 2 (2021): Indonesian Journal of Anti-Aging Medicine
Publisher : Fakultas Kedokteran Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36675/ijaam.v5i2.87

Abstract

Introduction: The exposure to UV may cause skin disorders, including hyperpigmentation. Petai seeds are categorized as traditional medicinal plants that have anti-inflammatory and antioxidant effects, such as flavonoids, tannins, phenols and vitamin C which have the function of inhibiting the tyrosinase enzyme and the synthesis of melanin. The aim of this research was to prove that a 20% of Petai seed (Parkia speciosa) extract cream could prevent the increase of melanin counts in the skin of Guinea Pigs (Cavia porcellus) exposed to UV-B. Method: This research employed an experimental study through a randomized post-test only control group design that used 36 male guinea pigs (Cavia porcellus) that divided into 2 (two) groups each of which were 18 guinea pigs. In order to find out the mass, melanin stained with Masson-Fontana, the melanin count was showed in percent. The results of this research were then analyzed and used descriptive analysis, data normality, data homogeneity, and comparability tests. Results: The results indicated that the mean was 20.543 ± 3.344%, whereas, in the treatment group that smeared by 20% of petai seed extract cream, the mean value was 1.533 ± 0.518% (p <0.001). This indicated that the treatment group had a smaller melanin count than the control group. Conclusion: Based on the results of this research, it can be concluded that 20% of petai seed extract cream inhibited the increase of melanin counts in guinea pigs’ skin exposed to UV-B.
Co-Authors AAGP Wiraguna Wimpie I Pangkahila