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All Journal IJAAM (Indonesian Journal of Anti-Aging Medicine)
Ni Nyoman Ayu Dewi
Biochemistry department of Andrology and Sexology, Faculty of Medicine, Universitas Udayana, Denpasar, Bali
Medicine & Pharmacology

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Ethanol extract of Neem (azadirachta indica a. juss) twigs peel gel increased neovascularization, fibroblast and epithelialization in wound healing of male albino Wistar rats (Rattus norvegicus) Noviyanti Situmorang; I Gusti Made Aman; Ni Nyoman Ayu Dewi
IJAAM (Indonesian Journal of Anti-Aging Medicine) Vol 4 No 1 (2020): Indonesian Journal of Anti-Aging Medicine
Publisher : Fakultas Kedokteran Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36675/ijaam.v4i1.54

Abstract

Introduction: Proper wound healing is characterized by increased neovascularization, fibroblast cell number and epithelialization. This process can be accelerated using several natural substances and one of them is Neem (Azadirachta indica A. Juss) twigs extract. However, its wound healing effect is still poorly investigated. Therefore, the aim of this study was to assess the efficacy of ethanol extract of Neem twigs peel gel toward wound healing in male albino Wistar rats (Rattus norvegicus). Methods: A randomized posttest only control group study was conducted using 28 male albino Wistar rats as a subject. Subjects were divided into four groups; the first and second group was the control group which was treated using placebo gel for 4 and 12 days while the third and fourth groups were treated with 12.5% extract gel for 4 and 12 days. On day 4 and 12, rats were euthanized then examined histologically. Results: The results showed a significant increase of neovascularization in the P1.4 compared to P0.4. However, it decreased significantly at day 12. Similarly, the number of fibroblast cells was also increased in the treatment group until day 4 but decreased significantly and even lower than the control group at day 12. On contrary, epithelialization was continuously increased in both group and the treatment groups consistently demonstrated higher epithelialization compared to control. Conclusion: It can be concluded that ethanol extract of Neem twigs peel gel enhanced wound healing process in male albino Wistar rats.
Awarding of green coffee bean (Coffea arabica) extract improved lipid profile in dyslypidemic male wistar rats (Rattus norvegicus) Fibriany Chandra; I Wayan Weta; Ni Nyoman Ayu Dewi
IJAAM (Indonesian Journal of Anti-Aging Medicine) Vol 5 No 2 (2021): Indonesian Journal of Anti-Aging Medicine
Publisher : Fakultas Kedokteran Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36675/ijaam.v5i2.83

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Introduction: Dyslipidemia is a lipid metabolic disorder characterized by increased or decreased lipid fraction in plasma. The active compounds of chlorogenic acid in coffee can increases the body’s metabolism, increases fatty acid oxidation, decreases triglyceride levels in the liver, and inhibit the action of the enzyme amylase and lipase pancreas in the intestinal. This study aimed to prove the effectiveness of green coffee bean extract in improving serum lipid profile levels in dyslipidemic male Wistar rats. Methods: The research design was experimental pre-post test control group using 14 male Wistar rats. The control group was given placebo (2 cc aquades), while the second group was treated with ethanol extract of green beans dose 200 mg/kg dissolved in 2 cc aquades given sonde with treatment time of 14 days. On the first and fifteenth days, blood sampling is done to check the lipid profile level. Results: The results showed that the mean total cholesterol level of the control group was 137.86 ± 10.12 mg/dL while the total cholesterol level in the treatment group was 137.86 ± 10.12 mg/dL. The mean of triglyceride level, LDL level, and HDL level control group was 100.86 ± 8.98 mg/dL, 97.57 ± 4.65 mg/dL, and 51.57 ± 4.96 mg/dL while triglyceride level, LDL level, and HDL level in treatment group was 76.86 ± 4.94 mg/dL, 82.86 ± 5.21 mg/dL and 66.43 ± 8.84 mg/dL. Conclusion: Arabica green coffee bean (Coffea arabica) extract improves the lipid profile of dyslipidemic male Wistar rats (Rattus norvegicus).
Co-Authors Fibriany Chandra I Gusti Made Aman I Wayan Weta Noviyanti Situmorang