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All Journal IJAAM (Indonesian Journal of Anti-Aging Medicine)
Anak Agung Gede Budhiarta
Endocrinology Division, Department of Internal Medicine, Faculty of Medicine Universitas Udayana/Sanglah General Hospital
Medicine & Pharmacology

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The oral administration of zinc sulfate in increasing the mass of pancreatic β cell and reducing the level of fasting blood glucose and glycated albumin in male wistar rats (Rattus norvegicus) with diabetes mellitus Silvia Irani; Anak Agung Gede Budhiarta; I Gusti Made Aman
IJAAM (Indonesian Journal of Anti-Aging Medicine) Vol 5 No 2 (2021): Indonesian Journal of Anti-Aging Medicine
Publisher : Fakultas Kedokteran Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36675/ijaam.v5i2.82

Abstract

Introduction: Diabetes mellitus (DM) is a degenerative disease that can accelerate the aging process. Zinc is a mineral that has antioxidant potential that can increase the cell growth and it also protects pancreatic β cell mass from cell death during diabetes. This study aimed to prove that oral administration of zinc sulfate could increase the pancreatic β cells mass and decrease the level of fasting blood glucose (FBG) and glycated albumin (GA) in male Wistar rats with DM. Methods: This research employed a pure experimental research with post test only control group design by using 36 male Wistar rats. The placebo group that administered with 1 cc of aquadest and the group of zinc that administered by oral zinc sulfate of 100 mg/kgBW in which had been dissolved with 1 cc of aquadest. The assessment of pancreatic β cell mass and FBG levels and glycated albumin were carried out after 30 days of treatment. Results: The analysis by using the Shapiro-Wilk test was distributed normally. The result of Laven’s test indicated that the distribution of data and variants of the groups were homogeneous. The comparative results of the two groups using an independent t-test, there were significant differences between both groups on the mass of pancreatic β cell and the level of fasting blood glucose and glycated albumin (p <0.05). Conclusion: The oral administration of zinc sulfate can increase the pancreatic β cell mass and decrease the level of FBG and glycated albumin in male Wistar rats with DM.
Oral administration of arabica green coffee extract increased fasting insulin, decreased fasting blood glucose, but did not decrease insulin resistance on wistar male rat (Rattus norvegicus) obese with diabetes mellitus Maria Marissa Maharani; Anak Agung Gede Budhiarta; I Wayan Weta
IJAAM (Indonesian Journal of Anti-Aging Medicine) Vol 5 No 1 (2021): Indonesian Journal of Anti-Aging Medicine
Publisher : Fakultas Kedokteran Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36675/ijaam.v5i1.60

Abstract

Background: Type 2 DM is characterized by defective insulin secretion and increased insulin resistance, with the main management is the control of behavior, such as diet. Green Coffee Arabica is one of the nutraceutical contains polyphenols which have anti-diabetic activity. This study aimed to prove that Arabica green coffee extract increases fasting insulin, decreases fasting blood glucose levels, and insulin resistance in male rat (Rattus Norvegicus) obese with diabetes. Methods: Experimental pretest-posttest groups study using 18 obese diabetic male albino rats. The control group was treated with placebo and the treatment group was treated with green coffee extract 300 mg/kgBW for 14 days. Fasting blood glucose and fasting insulin were measured before and after treatment. Results: There were a significant decrease of insulin levels in control group [from 6.59 to 3.67 mIU/L; p=0.011]. The change of insulin concentration between control group and treatment group were significant different statistically [-2.91 vs +1.57 mIU/L; p=0.024]. Significant decrease in fasting blood glucose in treatment group [from 162 to 120 mg/dL; p = 0.011]. The change fasting blood glucose between control group and treatment group were highly significant different statistically (+8 vs -44 mg/dL; p<0.001). Posttest HOMA-IR in treatment group and control group were not significant different statistically [2.49vs3.26; p=0.310] and the change HOMA-IR between control group and treatment group were not significant different statistically [-1.83 vs -0.497; p=0.145]. Conclusion: Oral administration of arabica green coffee extract increased insulin, decreased fasting blood glucose, but did not reduce insulin resistance on diabetic wistar rats.
Co-Authors I Gusti Made Aman I Wayan Weta Maria Marissa Maharani Silvia Irani