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All Journal Molekul: Jurnal Ilmiah Kimia
Suwandri Suwandri
Jurusan Kimia, Program Sarjana MIPA Unsoed Purwokerto
Chemical Engineering, Chemistry & Bioengineering Chemistry

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ISOLASI DAN IDENTIFIKASI SENYAWA KIMIA SERTA UJI AKTIVITAS ANTICANDIDAISIS SERBUK DAUN SIRIH DUDUK (Piper sarmentosum Roxb. Ex Hunter) Suwandri Suwandri; Hartiwi Diastuti
Molekul Vol 1, No 1 (2006)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (179.653 KB) | DOI: 10.20884/1.jm.2006.1.1.18

Abstract

Sirih duduk or Piper sarmentosum Roxb. ex Hunter have been long used the people in Indonesia for traditional medicine to cure various diseases. One of them was used to treat fungoid diseases. This research was aimed to examine the anticandidaisis activity from extract of P. sarmentosum leaves and to isolate and identify the anticandidaisis compounds from P. sarmentosum leaves. The isolation bioactive compounds of P. sarmentosumleaves was performed by extraction the powder of P. sarmentosum leaves using methanol and the bioactivity tests were performed against Candida albicans. The methanol extracts was then fractionated using organic solvents such as n-hexane, benzene, chloroform, and ethyl acetate. Identification of the bioactive compounds was carried out using ultraviolet-visible spectrometry, fourier transform infra red spectrometry and gas chromatography-mass spectrometry. The result showed that the chloroform fraction of methanol extract of P. sarmentosum leaves have activity against C. albicans. The fractionation was performed by coloumn chromatography using n-hexane-ethyl acetate(1:1) eluent. A bioactive compound of sinamic acid derivative was 4-ethoxy-2-hidroxy-3,5-dimethoxy sinamic acid could be purely isolated.
FRAKSINASI EKSTRAK METANOL KULIT BATANG Rhizophora mucronata DAN UJI DAYA HAMBATNYA TERHADAP BAKTERI Escherichia coli Dian Riana Ningsih; Warsinah Warsinah; Suwandri Suwandri
Molekul Vol 1, No 1 (2006)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (122.293 KB) | DOI: 10.20884/1.jm.2006.1.1.20

Abstract

Rhizhophora mucronata is commonly found mangrove plant due to it’s wide distribution. The bark of this plant used for traditional medicine as slimming, antidiarrhea , anticonstipation. The chemical compounds of R. mucronata are tannins, alcaloide, flavanoids and saponin. In order to find out the effect of chemical activity of this plant, a research entitled Fractionation Metanol Extracts Bark of R. Mucronata and Inhibiting Capacity Assay againstEscherichia coli Bacteria has been carried out.The bark of R. mucronata was extracted by soxhlet with methanol solvent. Than methanol extract was fractionated with developing solvent kloroform : metanol (1:9) and producing five fractions that gave positive result on test for alcaloide compounds. The result of infrared spectroscopy that fraction 1-5 also contains of alcaloide. All fractions from coulomn chromatography tested on E. coli with dilution method which gave result that these fractions inhibit the growth of E. coli.
Co-Authors Dian Riana Ningsih Hartiwi Diastuti Warsinah Warsinah