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All Journal Jurnal Kesehatan Jurnal farmasi UIN Alauddin Makassar Jurnal Sains dan Kesehatan
Surya Ningsi
Universitas Islam Negeri Alauddin Makassar
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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KARAKTERISASI MIKROKRISTALIN SELULOSA DARI KULIT JAGUNG PULUT (Zea mays L. Var Ceratina Kulesh) Surya Ningsi; Nining Iklasita; Munifah Wahyuddin; Syamsuri Syakri
Jurnal Kesehatan THE 2nd ALAUDDIN PHARMACEUTICAL CONFERENCE AND EXPO (ALPHA-C) 2020
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/kesehatan.v1i1.15294

Abstract

Corn husk is a part of the plant that has a high cellulose fiber content, which is around 44.08%, so it is potentially to be used as a source of raw material of microcrystalline cellulose. The purpose of this research was to synthesize and determine the characteristics of microcrystalline cellulose produced from corn husk. The making of microcrystalline cellulose was carried out in two stages, namely delignification using NaOH solvent with five variations of concentration (7,5%, 10%, 12,5%, 15% and 17,5%) and hydrolyzed using 2,5 N HCl. Characteristic test for microcrystalline cellulose included organoleptic, pH, flow time and stationary angle, FTIR, and XRD. The results showed that microcrystalline cellulose produced from corn husk had characteristics such as fine powder, white and odorless, pH was 7.0, flow time was 0.3 g/sec, a stationary angle was 54o, FTIR analysis showed a typical peak of cellulose namely 3411,05 for O-H and 2900,61 for C-H, with a crystallinity degree was 79%.
AKTIVITAS PENGHAMBATAN ENZIM TIROSINASE EKSTRAK METANOL KLIKA ANAK DARA (Croton oblongus Burm F.) Afrisusnawati Rauf; Surya Ningsi; Andi Hasriani; Mukhriani Mukhriani
Jurnal Kesehatan THE 2nd ALAUDDIN PHARMACEUTICAL CONFERENCE AND EXPO (ALPHA-C) 2020
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/kesehatan.v1i1.18220

Abstract

Anak dara plant (Croton oblongus Burm. F) has been used by the people of Sinjai, South Sulawesi for generations as traditional cosmetics. Several studies have proven that this plant has antioxidant activity and sunscreen activity. Tyrosinase inhibitors are used in cosmetics to prevent hyperpigmentation. Inhibitory activity of the enzyme tyrosinease Anak dara tree bark (Croton oblongus Burm. F) has never been reported. This study aims to find out the inhibitory activity of tyrosinease enzyme of methanol extract Anak dara tree bark (Croton oblongus Burm. F). The extraction method used is maceration. Testing was carried out with L-tyrosine as a substrate, a methanol extract of Anak dara tree bark (Croton oblongus Burm. F) with concentrations of 20 ppm, 40 ppm, 60 ppm, 80 ppm, and 100 ppm, and Cojic acid as a positive control and then measured absorption using a micro plate reader at a wavelength of 490 nm. The results showed that the extract of methanol Anak dara tree bark (Croton oblongus Burm. F) has strong inhibitory activity of tyrosinase enzyme with an IC50 value of 76.80 μg/mL.
FORMULASI DAN KARAKTERISASI NANOKAPSUL DARI EKSTRAK DAUN PARANG ROMANG (Boehmeria virgata (Forst) Guill) BERDASARKAN VARIASI KONSENTRASI INTI DAN PENYALUT Surya Ningsi
Jurnal Farmasi UIN Alauddin Makassar Vol 1 No 1 (2013): Jurnal Farmasi
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/jurfar.v1i1.2098

Abstract

Ekstrak n-heksan Parang Romang (Boehmeria virgata) memiliki aktifitas antiproliferasi terhadap sel kanker HeLa dengan nilai IC50 yaitu 3,453 µg/ml (Manggau M. et al, 2007). Dengan data IC50 tersebut menunjukkan bahwa daun Parang Romang memiliki senyawa yang dapat membunuh sel kanker HeLa sehingga dapat dikembangkan menjadi salah satu alternatif dalam pengobatan kanker leher rahim. Penelitian ini bertujuan untuk membuat formula nanokapsul ekstrak daun Parang Romang yang memiliki karakter fisik yang terbaik. Pembuatan nanokapsul ekstrak daun Parang Romang dengan karakter fisik yang baik dilakukan berdasarkan perbandingan variasi konsentrasi inti dan penyalut menggunakan metode gelasi ionik. Hasil penelitian menunjukkan bahwa nanokapsul yang dibuat dengan perbandingan konsentrasi inti dan penyalut 1:3 memiliki karakter fisik yang terbaik dengan persentase bobot nanokapsul yang dihasilkan 76,80%; efisiensi enkapsulasi 19,49%; efisiensi pengisian ekstrak ke dalam nanokapsul 4,23%; dan besaran partikel 149,0 nm; 178,4 nm; 262,7 nm.
PENENTUAN POTENSI TABIR SURYA EKSTRAK KLIKA ANAK DARA (Croton oblongus Burm F.) Haeria Haeria; Surya Ningsi; Israyani Israyani
Jurnal Farmasi UIN Alauddin Makassar Vol 2 No 1 (2014): Jurnal Farmasi
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/jurfar.v2i1.2148

Abstract

A study concerning the determination of the potential sunscreen extract cortex anak dara (Croton oblongus Burm f.) UV-Vis spectrophotometry. This study aims to determine the SPF value, percent transmission erythema (% Te), and the percent transmission of pigmentation (% Tp) of the extract cortex anak dara (Croton oblongus Burm f.) with use spectrophotometer UV-Vis. Determination of potential sunscreen SPF value is determined based on the calculation of %Te and %Tp. The measurement results indicate that the SPF value of the extract with a concentration of 300 ppm = 2,991. Value of %Te = 22, 655%, and the value of %Tp = 26.837%. SPF value can be determined extract cortex anak dara (Croton oblongus Burm f.) at a concentration of 300 ppm has a minimum level of protection and sunscreen for the result value %Te and %Tp extract cortex anak dara (Croton oblongus Burm f.) is said to not be able to hold the skin to prevent redness / erythema, but can withstand pigmentation or darkening of the skin.
OPTIMASI NANOKAPSUL ASPIRIN YANG TERSALUT KITOSAN– GOM GUAR YANG DIPAUT SILANG DENGAN NATRIUM TRIPOLIFOSFAT Surya Ningsi; Ismail Ismail; Andi Ulfiana Utari
Jurnal Farmasi UIN Alauddin Makassar Vol 2 No 4 (2014): Jurnal Farmasi
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/jurfar.v2i4.2157

Abstract

A researched has been done about optimation of chitosan – guar gum crosslinked with sodium tripolyphosphate as coating agents nanocapsule aspirin. The researched purposed to get the best coating aspirin adsorption is based from observation of morpology and effisiency encapsulation.Nanocapsule formulations made with ionic gelation methods, using variation concentration of chitosan (1,5%, 1,75%, 2%), guar gum (0,75%, 0,55%, 0,35%), with fixed concentration of sodium tripolyphosphate (5%). Nanocapsules aspirin was measured using UV-Vis Spectrophotometry at a wavelength of 287 nm. Observation of the shape and size of the particles was performed using SEM (Scanning Electron Microscope). Encapsulation Effisiency obtained from formula A, B, and C of 28%, 52,6%, and 31,2%. Formula with chitosan concentration 1,75%, 0,55% guar gum, and 5% sodium tripolyphosphate (Formula B) has the best characteristics of the encapsulation effisiencyof 52,6%, the not sferis shape of the particles and more uniform thet the smallest particles size was 400 nm and the largest particle size was 2400 nm.
FORMULASI SEDIAAN LULUR KRIM AMPAS KEDELAI PUTIH DAN AMPAS KOPI ARABIKA Surya Ningsi; Faridha Yenny Nonci; Rifqiyati Sam
Jurnal Farmasi UIN Alauddin Makassar Vol 3 No 1 (2015): Jurnal Farmasi
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/jurfar.v3i1.2173

Abstract

The  formulation  of  herbal  preparations  have  been  done  scrub  cream  white soybean dregs and arabica coffee dregs using a variation of the type of emulsifier, the nonionic surfactant (tween 80 and span 80) and a anionic surfactant (sodium lauryl sulfate). This study aims to determine the type of emulsifier which has good physical stability. Test stability scrub cream dosage is determined based on observations of organoleptic (color, smell and shape), creaming, viscosity, size of the dispersed drops, pH and phase inversion on the condition before and after accelerated storage at a temperature of 5oC and 35oC. Statistical analysis showed that the RAK emulsifier no significant differences on viscosity scrub cream before and after the storage accelerated and does not give any influence on organoleptic, the size of the dispersed drops, the pH before and after accelerated storage. The results of the study showed no creaming and inverse phase with all the scrub cream, so that all can be categorized as scrub cream with good stability.
UJI EFEK GEL EKSTRAK ETANOL DAUN TEMBELEKAN (LANTANA CAMARA LINN.) TERHADAP PENYEMBUHAN LUKA SAYAT PADA KELINCI (ORYCTOLAGUS CUNICULUS) Surya Ningsi; Khairunnisa Khairunnisa; Nur Ida
Jurnal Farmasi UIN Alauddin Makassar Vol 3 No 2 (2015): Jurnal Farmasi
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/jurfar.v3i2.2204

Abstract

Research Test The Effect Gel Ethanolic Extract of Tembelekan Leaf (Lantana camara L.) to cuts wound healing in Rabbits (Oryctolagus cuniculus) as been done with the objective to determine the effectiveness of Tembelekan (Lantana camara L.) leaf ethanol extract gel to healing  cuts wound in rabbits. The method used were extraction of the sample is by maceration, Formulation gel with varian consentration ethanolic extract of Tembelekan leaf (Lantana camara L.) were 1%, 2%, 4% and base gel without extract, test the effect in skin rabbits has been cuts wound healing in skin rabbitsfor all of the formula, positive control and negative control. Result of Research were given for extract 1%, 2%, dan 4%, positive control, and negative control average on the 12th, 11th, 9th, 6th, and 14th. From the result of statistical test completely randomized design (CRD) and the least significant difference test (LSD) can be conclueded that gel were given more effectif are ethanolic of Tembelekan (Lantana camara L.) extract content of 4%.
PENGARUH JENIS PENGIKAT TERHADAP SIFAT FISIKA SEDIAAN SERBUK MASKER WAJAH KULIT BUAH SEMANGKA (CITRULLUS VULGARIS SCHRAD) Isriany Ismail; Surya Ningsi; Nurshalati Tahar; Aswandi Aswandi
Jurnal Farmasi UIN Alauddin Makassar Vol 2 No 2 (2014): Jurnal Farmasi
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/jurfar.v2i2.2210

Abstract

Telah dilakukan penelitian tentang Pengaruh Jenis Pengikat Terhadap Sifat Fisika Sediaan Serbuk Masker Wajah Kulit Buah Semangka (Citrullus vulgaris Schrad ). Penelitian ini bertujuan untuk mengetahui pengaruh agen pengikat terhadap sifat fisika sediaan serbuk masker wajah Kulit Buah Semangka (Citrullus vulgaris Schrad) dan jenis agen pengikat terbaik yang dapat dijadikan formula sediaan serbuk masker wajah. Evaluasi kestabilan fisika dilakukan dengan pengamatan organoleptis, pengamatan ukuran partikel granul sediaan, laju alir dan sudut istirahat, kelembaban, uji daya serap air, uji pH, uji daya sebar, uji daya lekat, dan uji homogenitas sediaan. Formulasi sediaan masker wajah Kulit Buah Semangka (Citrullus vulgaris Schrad ) menggunakan tiga jenis agen pengikat yang berbeda yaitu Karbopol 940, Na.CMC, dan HPMC K4M dengan bahan aktif serbuk Kulit Buah Semangka dan menggunakan bahan tambahan pati beras ketan putih. Hasil penelitian menunjukkan bahwa ketiga jenis sediaan berwarna hijau kecokelatan dan memiliki bau khas lemak. Ukuran partikel granul pengikat Na.CMC yaitu 1 mm, Karbopol 940 yaitu 1 mm, HPMC K4M yaitu 1 mm. Laju alir pengikat Na.CMC yaitu 1,9 g/s, Karbopol 940 yaitu 2 g/s, HPMC K4M yaitu 1,9 g/s. Sudut istirahat pengikat Na.CMC yaitu 23,2o, Karbopol 940 yaitu 23o, HPMC K4M yaitu 23,7o. Kelembaban pengikat Na.CMC yaitu 1%, Karbopol 940 yaitu 2%, HMPC yaitu 1%. Daya serap air pengikat Na.CMC yaitu 5,57 ml, Karbopol 940 yaitu 6,9 ml, HPMC K4M yaitu 6 ml. pH ketiga jenis pengikat yaitu Na.CMC 5, Karbopol 940 6, dan HPMC K4M 6. Daya sebar pengikat Na.CMC yaitu 5,57 mm/g, Karbopol 940 3,23 mm/g, HMPC yaitu 2,28 mm/g. Daya lekat pengikat Na.CMC yaitu 27 menit, Karbopol 940 yaitu 29 menit, HPMC K4M yaitu 23 menit. Homogenitas ketiga jenis pengikat yaitu homogen. Secara keseluruhan hasil pengamatan menunjukkan ketiga jenis pengikat tidak mempengaruhi sifat fisika sediaan serta ketiga jenispengikat baik untuk digunakan sebagai pengikat sediaan.
STUDI KEMAMPUAN PATI BIJI ALPUKAT (Persea americana Mill) PREGELATINASI SEBAGAI BAHAN PENGHANCUR PADA TABLET PARACETAMOL KEMPA LANGSUNG Surya Ningsi; Dwi Wahyuni Leboe; Qurratul Aeni
Jurnal Farmasi UIN Alauddin Makassar Vol 4 No 3 (2016): Jurnal Farmasi
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/jurfar.v4i3.2233

Abstract

Researched about the study of the ability of pregelatinized avocado seeds (Persea americana Mill) starch as disintegrant by direct compression of paracetamol tablets formulation.This Research suppose to know about the ability of pregelatinized avocado seeds starch as disintegrant and optimum concentration of pregelatinized avocado seeds starch as disintegrant on direct compression fulfill the qualification good tablets.Pregelatinized starch produced by heating in its gelatinated temperature, next dried and standardized its measure. Then, evaluated according to granul evaluation. Mixing the mass of tablets, Three formulas were made by disintegrants concentration different (pregelatinized avocado seeds starch) FI 5%, FII 10% dan FIII 15%. Next, evaluated. Tablets compressed by direct compression method and evaluated.The evaluation results pregelatinized avocado seeds starch regularly have particle size 231,3μm, angel of repose 22,76o, fluidity 7,40/det, density true 1,21g/ml, density bulk 0,68 g/ml, density tapped 0,72 g/ml, porosity 40,84 %, compressibility index 3,77%, hausner’s ratio 1,03 and LOD 0,39%. The result show that pregelatinized avocado seeds starch have a good compressibility and fluidity. Result test for tablets show all formulas fulfill the qualification the tablets size uniformity, FII dan FIII fulfill the qualification at the weights uniformity, its hardness regulary 4,51 kg; 6,39 kg; 4,23 kg, friability 1,4%; 0,07%, and 1,50% and disintegration time 0,27 minute; 0,44 minute and 0,04 minute.From this result can be concluded that the pregelatinized avocado seeds starch can be used as a disintegrant on direct compression and the optimum concentration on direct compression pregelatinized avocado seeds of the produce tablets fulfill the qualification a good tablets is FII (10%).
FORMULASI DAN UJI STABILITAS FISIK GEL EKSTRAK DAUN BINAHONG (Andredera cordifolia) Surya Ningsi; Dwi Wahyuni Leboe; Sri Armaya
Jurnal Farmasi UIN Alauddin Makassar Vol 4 No 1 (2016): Jurnal Farmasi
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/jurfar.v4i1.2242

Abstract

A research on the Formulation and Physical Stability Test Preparations Gel Binahong Leaf Extract (Andredera cordifolia). This study aims to determine the effect of the type and concentration of the base of the physical stability of the gel extracted using leaf samples binahong (Andredera cordifolia) by using 96% ethanol by maceration method. Gel formulation using 2 carbopol gel base is a base 940 and NaCMC. Each base is made in 3 concentration. Base is 0.5% carbopol 940, 1.25%, and 2%. NaCMC 3%, 4.5%, and 6% in addition to the base gel was also used as a negative control. Test is determined by observation of the organoleptic characteristics include color, smell, shape, pH probe, homogeneity inspection, test dispersive power, consistency test, test syneresis and viscosity determination. The results showed 940 carbopol gel with 1.25% concentration is shown in formula B is gelling who has the best physical stability for binahong leaf extract gel (Andredera cordifolia).
Co-Authors A.Armisman Edy P Achsanul Husna Afrisusnawati Rauf Andi Hasriani Andi Ulfiana Utari Aswandi Aswandi Dwi Wahyuni Leboe Faridha Yenny Nonci Haeria Haeria Haeria Haeria Hamida Hamida Ismail Ismail Israyani Israyani Isriany Ismail Karlina Amir Tahir Khairunnisa Khairunnisa Mukhriani, Mukhriani Nining Iklasita Nur Azizah Syahrana Nur Ida Nur Syamsi Dhuha Nurshalati Tahar Qurratul Aeni Rezky Nurul Fadhilah Rifqiyati Sam Sri Armaya Syamsuri Syakri UL Miftahurrahmah Ulfa Utami Amrus Wahyuddin, Munifah