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Surya Ningsi
Jurusan Farmasi Fakultas Kedokteran dan Ilmu Kesehatan Universitas Islam Negeri Alauddin Makassar
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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STUDI KEMAMPUAN PATI BIJI ALPUKAT (Persea americana Mill) PREGELATINASI SEBAGAI BAHAN PENGHANCUR PADA TABLET PARACETAMOL KEMPA LANGSUNG Surya Ningsi; Dwi Wahyuni Leboe; Qurratul Aeni
Jurnal Farmasi UIN Alauddin Makassar Vol 4 No 3 (2016): Jurnal Farmasi
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/jurfar.v4i3.2233

Abstract

Researched about the study of the ability of pregelatinized avocado seeds (Persea americana Mill) starch as disintegrant by direct compression of paracetamol tablets formulation.This Research suppose to know about the ability of pregelatinized avocado seeds starch as disintegrant and optimum concentration of pregelatinized avocado seeds starch as disintegrant on direct compression fulfill the qualification good tablets.Pregelatinized starch produced by heating in its gelatinated temperature, next dried and standardized its measure. Then, evaluated according to granul evaluation. Mixing the mass of tablets, Three formulas were made by disintegrants concentration different (pregelatinized avocado seeds starch) FI 5%, FII 10% dan FIII 15%. Next, evaluated. Tablets compressed by direct compression method and evaluated.The evaluation results pregelatinized avocado seeds starch regularly have particle size 231,3μm, angel of repose 22,76o, fluidity 7,40/det, density true 1,21g/ml, density bulk 0,68 g/ml, density tapped 0,72 g/ml, porosity 40,84 %, compressibility index 3,77%, hausner’s ratio 1,03 and LOD 0,39%. The result show that pregelatinized avocado seeds starch have a good compressibility and fluidity. Result test for tablets show all formulas fulfill the qualification the tablets size uniformity, FII dan FIII fulfill the qualification at the weights uniformity, its hardness regulary 4,51 kg; 6,39 kg; 4,23 kg, friability 1,4%; 0,07%, and 1,50% and disintegration time 0,27 minute; 0,44 minute and 0,04 minute.From this result can be concluded that the pregelatinized avocado seeds starch can be used as a disintegrant on direct compression and the optimum concentration on direct compression pregelatinized avocado seeds of the produce tablets fulfill the qualification a good tablets is FII (10%).
STUDI KEMAMPUAN PATI BIJI ALPUKAT (Persea americana Mill) PREGELATINASI SEBAGAI BAHAN PENGHANCUR PADA TABLET PARACETAMOL KEMPA LANGSUNG Surya Ningsi; Dwi Wahyuni Leboe; Karlina Amir Tahir; Qurratul Aeni
Jurnal Farmasi UIN Alauddin Makassar Vol 4 No 4 (2016): Jurnal Farmasi
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/jurfar.v4i4.2258

Abstract

Researched about the study of the ability of pregelatinized avocado seeds (Persea americana Mill) starch as disintegrant by direct compression of paracetamol tablets formulation. This Research suppose to know about the ability of pregelatinized avocado seeds starch as disintegrant  and optimum concentration of pregelatinized avocado seeds starch as disintegrant on direct compression fulfill the qualification good tablets.Pregelatinized starch produced by heating in its gelatinated temperature, next dried and standardized its measure. Then, evaluated according to granul evaluation. Mixing the mass of tablets, Three formulas were made by disintegrants concentration different (pregelatinized avocado seeds starch) FI 5%, FII 10% dan FIII 15%. Next, evaluated. Tablets compressed by direct compression method and evaluated.The evaluation results pregelatinized avocado seeds starch regularly have particle size 231,3µm, angel of repose 22,76o, fluidity 7,40/det, density true 1,21g/ml, density bulk 0,68 g/ml, density tapped 0,72 g/ml, porosity 40,84 %, compressibility index 3,77%, hausner’s ratio 1,03 and LOD 0,39%. The result show that pregelatinized avocado seeds starch have a good compressibility and fluidity. Result test for tablets show all formulas fulfill the qualification the tablets size uniformity, FII dan FIII fulfill the qualification at the weights uniformity, its hardness regulary 4,51 kg; 6,39 kg; 4,23 kg,  friability 1,4%; 0,07%, and 1,50% and disintegration time 0,27 minute; 0,44 minute and 0,04 minute. From this result can be concluded that the pregelatinized avocado seeds starch can be used as a disintegrant on direct compression and the optimum concentration on direct compression pregelatinized avocado seeds of the produce tablets fulfill the qualification a good tablets is FII (10%).
PENENTUAN TOKSISITAS FRAKSI EKSTRAK ETANOL BIJI BUAH SALAK (Salacca zalacca (Gaert.) Voss) ASAL KABUPATEN ENREKANG TERHADAP LARVA Artemia salina Leach DENGAN METODE BRINE SHRIMP LETHALITY TEST Surya Ningsi; A.Armisman Edy P; Hamida Hamida
Jurnal Farmasi UIN Alauddin Makassar Vol 6 No 2 (2018): Jurnal Farmasi
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/jurfar.v6i2.6754

Abstract

Penelitian ini dilakukan dengan tujuan untuk menentukan efek toksik dari fraksi ekstrak etanol biji buah salak (Salacca zalacca (Gaert.) Voss) terhadap larva Artemia salina Leach dengan menggunakan metode Brine Shrimp Lethality Test (BSLT) serta menentukan golongan senyawa yang terkandung dalam fraksi dengan nilai LC50 terkecil. Biji buah salak diekstraksi dengan pelarut etanol menggunakan metode refluks. Fraksinasi ekstrak etanol dilakukan dengan menggunakan kromatografi cair vakum dan diperoleh tiga fraksi gabungan yaitu fraksi A, B dan C. Uji toksisitas dilakukan dengan menggunakan larva udang Artemia salina Leach dan efek toksik diidentifikasi dengan persentase kematian larva udang menggunakan analisis probit.  Dari Hasil penelitian diperoleh bahwa ketiga fraksi A, B dan C memiliki nilai LC50 masing-masing sebesar 0,170 µg/ml; 0,988 µg/ml; dan 2,654 µg/ml. Hasil identifikasi fraksi A dengan efek toksik terbesar menunjukkan adanya kandungan senyawa aktif golongan triterpen dan steroid. Hasil penelitian ini menunjukan bahwa ketiga fraksi bersifat toksik dan berpotensi sebagai antikanker dimana fraksi A menunjukkan efek toksik yang lebih besar dibandingkan fraksi lainnya.
Co-Authors A.Armisman Edy P Dwi Wahyuni Leboe Hamida Hamida Karlina Amir Tahir Qurratul Aeni