Haryoto Saroyo
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Antioxidant Activity Using DPPH & Frap Method and Their Correlation with The Levels of Phenolic and Flavonoid Compounds from Nemba Plants (Azadirachta Indica A. Juss) Haryoto Saroyo; Ismi Aziz Nur Arifah
Journal of Nutraceuticals and Herbal Medicine Vol 3, No 2 (2020): JNHM 2020
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/jnhm.v3i2.15658

Abstract

One of the herbal plants, namely neem (Azadirachtaindica A. Juss) can generally be used as an ingredient for traditional medicine. Neem is known to have the potential to produce antioxidants, where it can play an important role in counteracting free radicals. As a result of the increasing number of free radicals, the number of antioxidants and free radicals becomes unbalanced. If this continues, it can cause problems, namely the emergence of various kinds of serious diseases. The purpose of this literature review is to present articles related to the potential for antioxidant activity; content of phenolic compounds and flavonoids; knowing whether there is a relationship between phenolic compounds and flavonoids on antioxidant activity; as well as providing information related to other potentials of neem (Azadirachta indica A. Juss) plants. Several studies have stated that the neem plant has antioxidant activity. The strongest antioxidant activity was found in the neem root. The secondary metabolites produced are alkaloids, flavonoids, steroids, polyphenols, glycosides, phenols, tannins, essential oils, carotenoids, fatty acids, and saponins. Another study also stated that neem has the potential for other pharmacological activities such as antibacterial, immunomodulatory, antidiarrheal, and antifungal activities. polyphenols, glycosides, phenols, tannins, essential oils, carotenoids, fatty acids, and saponins. Another study also stated that neem has the potential for other pharmacological activities such as antibacterial, immunomodulatory, antidiarrheal, and antifungal activities. polyphenols, glycosides, phenols, tannins, essential oils, carotenoids, fatty acids, and saponins. Another study also stated that neem has the potential for other pharmacological activities such as antibacterial, immunomodulatory, antidiarrheal, and antifungal activities.
Cytotoxicity of Mangrove Leaves (Rhizophora) Ethanolic Extract on Cancer Cells Haryoto Saroyo; Nur Fajariyah Maulidah Saputri
Journal of Nutraceuticals and Herbal Medicine Vol 4, No 1 (2021): JNHM 2021
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/jnhm.v4i1.15657

Abstract

Cancer is a disease that can attack any part of the body when the abnormal cells begin to grow  uncontrollably beyond the limit, then attack the connected parts of the body and  spread to other organs. The mangrove (Rhizophora) is a herbal plant that can be used as a treatment for various diseases, one of which is cancer. The mangrove (Rhizophora) plant contains phytochemicals  ranging from fruit, seeds, leaves and roots. This review article aims to examine the cytotoxicity effects of mangrove (Rhizophora)  plants on cancer cells. The library sources in this article review use the Google Scholar and PubMed databases. The inclusion criteria used were articles containing the cytotoxic test of mangrove (Rhizophora) with the last 10 years of publication (2011-2020), original research, there were results of anticancer activity in the form of IC50 and research using   mangrove (Rhizophora).  plant extracts. The exclusion criteria used were articles that did not contain a full text, used plants with different genus, did not have an IC50 value and were not original research. From the journals that have been analyzed, it can be said that the extract of the mangrove (Rhizophora) plant can be developed for cancer treatment. The mangrove (Rhizophora) plant has cytotoxic activity because it contains active compounds in the form of phenolic, flavonoids and terpenoids. Based on the results of the cytotoxic test of mangrove (Rhizophora) extract, the plant parts that have the strongest cytotoxic effect are fruit.