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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Berkala Ilmiah Kedokteran Duta Wacana MEDICINUS Jurnal Kedokteran Meditek
Rizaldy Pinzon
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Systematic Review: Pre-Stroke Use of Angiotensin Receptor Blockers and Stroke Outcomes Ivana Purnama Dewi; Virandra B. Kusmanto; Kristin Purnama Dewi; Rizaldy Pinzon
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 2 (2018)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (635.902 KB) | DOI: 10.19106/JMedSci005002201815

Abstract

Background: Hypertension is the major risk factor and the most important modifiable risk factor for stroke. Angiotensin Receptor Blockers (ARB) are widely used in patient at high risk of cardiocerebrovascular events. The objective of this literature review was to determine the efficacy of pre-stroke use of ARB on stroke outcomes.Methods: Major medical databases (PubMed, MEDLINE, Clinical Key, Cochrane Library, EMBASE) were systematically searched using keyword: “hypertension”, “ARB”, “stroke”, and “outcome”. The search were limited to clinical trials published within the last 10 years, written in English, with full-text availability. We used GRADE Working Group to measure the quality of evidence.Results: Four clinical studies, three retrospective studies and one nationwide population-based cohort study met our inclusion criteria with total of 102.644 patients for analysis. The scientific quality of the studies varied from poor (1 study), moderate (1 study), and high quality (2 studies). Generally, the subjects of the studies were acute ischemic stroke patients. Three studies showed pre-stroke use of ARB were significantly associated with better stroke outcomes. Only one study found different result whereas pre-stroke use of ARB did not appear to affect stroke outcomes. Outcome of the studies was explored according to morbidity (severity and functional status upon discharge) and mortality (30-days mortality or in-hospital mortality). Several limitations were present, including non-random treatment assignment, retrospective study design, and lack of data for longitudinal medication exposure in observational studies.Conclusions: This systematic review shows evidence that there is possible benefit of pre-stroke ARB treatment in relation to better ischemic stroke outcomes. However, further studies with better research method quality are still needed. The efficacy of ARB treatment in relation to other type of stroke outcomes also needs to be furtherly examined.Keywords: ARB, pre-stroke, benefit, prognosis Makalah ini dipresentasikan dalam Poster Session 11th Scientific Meeting of Indonesian Society of Hypertension, 24-26 February 2017
DAMPAK PENERAPAN CLINICAL PATHWAY TERHADAP BIAYA PERAWATAN PASIEN STROKE ISKEMIK AKUT DI RS BETHESDA YOGYAKARTA Jemsner Stenly Iroth; Riris Andono Ahmad; Rizaldy Pinzon
Berkala Ilmiah Kedokteran Duta Wacana Vol 2, No 1 (2016): BERKALA ILMIAH KEDOKTERAN DUTA WACANA
Publisher : Faculty of Medicine Universitas Kristen Duta Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (287.402 KB) | DOI: 10.21460/bikdw.v2i1.38

Abstract

Latar Belakang dan Tujuan: Stroke bukan hanya menyebabkan beban dalam dunia kesehatan akan tetapi juga membebani baik dari segi ekonomi suatu negara, dan juga secara psikologis, terutama pada keluarga dengan pasien yang mengalami kecacatan total. Biaya langsung maupun tidak langsung dari perawatan stroke diperkirakan mencapai lebih dari 65 miliar US dollar, sehingga stroke dapat digolongkan sebagai penyakit termahal setara dengan penyakit kronis diabetes dan gangguan depresi. Adanya variasi dalam pelayanan kesehatan diperkirakan membawa dampak terhadap biaya yang tidak tetap dan bahkan berlebihan. Panduan tertulis berupa Clinical Pathway (CP) diharapkan mampu mengurangi variasi biaya ini, dengan tetap mempertahankan kualitas yang baik. Metoda Penelitian: Penelitian ini merupakan penelitian observasional inferensial, dengan metoda Retrospektif Kohort. Data yang diambil adalah data sekunder di RS Bethesda Yogyakarta, berupa database komputer. Sampel yang diambil berjumlah 130 orang, baik pada kelompok kontrol (Perawatan tanpa CP), maupun pada kelompok observasi (Perawatan dengan CP). Hasil: Terdapat perbedaan signifikan terhadap biaya perawatan stroke iskemik akut setelah penerapan CP (p=0,004), dimana rerata biaya perawatan pada kelompok dengan CP sebesar Rp 8.212.656,02 dan pada kelompok tanpa CP sebesar Rp 10.659.617,72 (setelah penyesuaian dengan tingkat inflasi dari BPSI sebesar 19,08%) dengan beda rerata sebesar Rp 2.446.961,70. Kesimpulan: Clinical Pathway mampu memberikan penurunan biaya perawatan terhadap perawatan stroke iskemik akut di RS. Bethesda Yogyakarta.
Tinjauan Neurobiology Gangguan Spektrum Autistik Rizaldy Pinzon; Lucas Meliala; Sri Sutarni
Jurnal Kedokteran Meditek vol. 14 no. 37 Mei-Agustus 2006
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v14i37.176

Abstract

Prognosis Tumor Otak Metastase Rizaldy Pinzon
Jurnal Kedokteran Meditek vol. 15 no. 39 Januari-April 2007
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v15i39.189

Abstract

Peran Kortikosteroid Sistemik Sebagai Terapi Adjuvan Nyeri Punggung pada Metastase Spinal Rizaldy Pinzon
Jurnal Kedokteran Meditek vol. 15 no. 40 Januari-April 2009
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v15i40.191

Abstract

Closing the Gap of Unmet Needs in Inflammatory Pain Management: Case Series of Predimenol for Pain Rizaldy Pinzon
MEDICINUS Vol. 34 No. 2 (2021): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (151.21 KB) | DOI: 10.56951/medicinus.v34i2.65

Abstract

Chronic inflammatory pain is major medical problem worldwide. Nonsteroidal anti-inflammatory drugs (NSAIDs) and selective cyclooxygenase (COX)-2 inhibitors are commonly used medications to treat chronic pain. However, these agents have been associated with serious gastrointestinal, renal and cardiovascular adverse effects. This limitation indicates a clear unmet need in terms of safety of current treatment options for the management of chronic inflammatory pain. Those adverse effects may caused by overlapping roles of COX-1 and COX-2 in physiological and pathophysiological processes. Predimenol is a herbal medicine that can be used to treat pain. Recent findings showed that these phytochemicals may directly act upon several inflammatory processes and offer compelling evidence that predimenol could reduce pain and inflammation. We report two cases and short review of the use of predimenol for pain management. Our review showed that predimenol formulations could be a valuable alternative treatment to relieve symptoms of pain with good safety profile. Further researches through large, high quality RCTs to investigate the clinical benefit of predimenol for pain management are needed.
Co-Authors Ivana Purnama Dewi Jemsner Stenly Iroth Kristin Purnama Dewi Lucas Meliala Riris Andono Ahmad Sri Sutarni Virandra B. Kusmanto