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Isolation of citronellal from Cymbopogon nardus (L) Rendle and its activity test as a burn healing in mice Yelfi Anwar; Novia Aditia Ningtiyas; Partomuan Simanjuntak
Current Research on Bioscences and Biotechnology Vol. 2 No. 1 (2020)
Publisher : Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/crbb.2020.2.1/NODZ4501

Abstract

Citronellal is one of the main compounds of essential oils of Cymbopogon nardus (L) Rendle, which is the most important chemical compound in the cosmetics and pharmacy industry. This study aimed to isolate the citronellal from the essential oil of Cymbopogon nardus (L) Rendle and activity on burns in male white mice (Mus musculus (L). The isolation method used column chromatography and n-hexane-ethyl acetate as eluent (20 : 1). The isolate obtained was used to burn activity on the back of male white mice (Mus musculus (L)). The ointment formula 0.25%, 0.5% and 1% were prepared using vaseline flavum. Based on the test using thin layer chromatography with the addition of cerium sulphate as a spotting appearance, was given one spot in the 4th isolate. Based on characterization data by UV-Vis spectrum, FTIR spectrum and GC-MS chromatogram showed that F4 isolate was citronellal. Based on the results of the burn activity on all concentrations, formula 1% showed the best burn healing activity. Citronellal can be isolated from the essential oil of Cymbopogon nardus (L) Rendle and has healing activities for burns in male white mice.
Karakteristik Sosiodemografi, Klinis, Dan Pola Terapi Antiretroviral Pasien HIV/AIDS di RSPI Prof. Dr. Sulianti Saroso Periode Januari - Juni 2016 Yelfi Anwar; Sucahyo Adi Nugroho; Niken Diaz Tantri
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 15 No. 01 Juli 2018
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (927.789 KB) | DOI: 10.30595/pharmacy.v15i1.1216

Abstract

HIV/AIDS merupakan suatu penyakit yang disebabkan oleh infeksi human immunodeficiency virus. Penyakit ini mengganggu sistem kekebalan tubuh dengan menekan dan menurunkan jumlah sel CD4 sehingga meningkatkan risiko infeksi oportunistik yang dapat dicegah dengan adanya terapi antiretroviral. Penelitian ini bertujuan untuk mengetahui karakteristik sosiodemografi, klinis, dan pola terapi antiretroviral pada pasien HIV/AIDS di RSPI Prof. dr. Sulianti Saroso periode Januari-Juni 2016. Desain penelitian ini adalah deskriptif dengan penelusuran data bersifat retrospektif. Sampel dalam penelitian ini adalah 124 pasien HIV/AIDS yang mendapatkan terapi antiretroviral di klinik Pokja HIV/AIDS dalam kurun waktu Januari hingga Juni 2016 data diambil dari rekam medis. Hasil penelitian menunjukkan pasien HIV/AIDS didominasi oleh laki-laki (74,19%) usia 30-39 tahun (40,32%) dengan jumlah CD4 terbanyak dibawah 200 sel/µl (59,29%) dengan stadium I (44,35%) disertai infeksi kandidiasis (17,74%), dimana pola terapi lini I yang digunakan adalah Tenofovir + Lamivudine + Evafirens (65,23%) dengan kepatuhan pasien 75%. Diharapkan penelitian ini dapat bermanfaat untuk perumusan program pencegahan dan tatalaksana HIV/AIDS di masa mendatang.
Penyuluhan Kesehatan Tentang Cara Kerja Obat Di Sekolah Dasar (SD) Muhammadiyah 17 – Jakarta Utara Yelfi Anwar; Seftian Putra Dwijaya Marpaung; Michael Michael
BERDIKARI Vol 2, No 1 (2019): Jurnal Berdikari Vol 2 No 1
Publisher : Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (207.617 KB) | DOI: 10.52447/berdikari.v2i1.4091

Abstract

Obat adalah benda atau zat yang dapat digunakan untuk merawat penyakit, meredakan atau menghilangkan gejala, atau mengubah proses kimia dalam tubuh. Obat merupakan bahan atau paduan bahan-bahan yang dimaksudkan untuk digunakan dalam menetapkan diagnosis, mencegah, mengurangi, menghilangkan, menyembuhkan penyakit atau gejala penyakit, luka atau kelainan fisik dan psikis pada manusia atau hewan. Di Amerika Serikat, seorang medis profesional dapat memperoleh obat dari perusahaan farmasi atau apotek (yang membeli obat dari perusahaan farmasi). Apotek dapat juga menyediakan obat secara langsung kepada pasien bila obat tersebut dapat dengan aman digunakan sendiri, atau diberi kuasa dengan resep yang ditulis oleh dokter. Dalam penyuluhan kesehatan tentang cara kerja obat di dalam tubuh di Sekolah Dasar (SD) Muhammadiyah 17- Jakarta Utara dengan umlah siswa 26 orang (Kelas 3). Media yang digunakan  digunakan dalam penyuluhan ini yaitu, banner, leaflet, dan power point untuk mendukung kegiatan menjadi lebih efektif. Dari beberapa siswa sebelum kami melakukan penyuluhan, sebagian besar mereka belum mengetahui tentang cara kerja obat di dalam tubuh oleh karena itu penyuluhan ini perlu kami lakukan di Sekolah Dasar tersebut. Dari penyuluhan yang telah dilakukan, dari total 26 siswa/i diperoleh persentase siswa yang telah memahami tentang bagaimana Cara Kerja Obat di dalam tubuh sebesar 93 % dan siswa yang masih belum memahami tentang bagaimana cara kerja obat di dalam tubuh sebesar 7%. Dengan adanya persentase yang diperoleh, secara garis besar siswa/i telah memahami tentang cara kerja obat. Kata Kunci: Penyuluhan, Cara kerja obat di dalam tubuhABSTRACTIn health education about the workings of drugs in the body in the Primary School (SD) Muhammadiyah 17- North Jakarta with 26 students (Class 3). The media used in this outreach are banner, leaflet and power point to support activities more effectively. From a number of students before we did counseling, most of them did not know about the workings of drugs in the body, so we needed to do this counseling at the elementary school. From counseling that has been done, from a total of 26 students obtained the percentage of students who have understood about how the drug works in the body by 93% and students who still do not understand about how the drug works in the body by 7%. With the percentage obtained, in general students have understood about how medicine works.Keywords: Counseling How the drug works in the body
Penyuluhan Penyakit Diabetes Mellitus kepada Remaja Sekolah Menengah Atas di Jakarta Utara Yelfi Anwar; Muhammad Dimas An-Naf; Maeesa Putri Lathiifah; Lesli Tiana; Ratih Hardianti; Dewi Puspitasari; Etika Dewi Maharani; Nia Khorotun Fadillah; Fatimah Tibbiya; Lulu Najmah; Kartika Kartika; Jodi Apriadi; Setya Astuti; Alicia Alicia; Naplatul Mahmudah; Indah Mareta Dwi Editia
Jurnal Pengabdian Masyarakat Farmasi : Pharmacare Society Vol 1, No 2 (2022): Vol 1 Edisi 2 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1119.791 KB) | DOI: 10.3731/phar.soc.v1i2.15569

Abstract

Diabetes mellitus counseling is an activity to provide information and education about Diabetes Mellitus (DM) to the community and schools. The counseling was held at the Al-Khariyah High School onsite, the target participants were 11th grade science students. This counseling aims to provide knowledge and understanding of DM and its risk factors, including Body Mass Index (BMI), blood pressure, physical activity habits, frequency of fruit and vegetable consumption, family history of DM, waist circumference (central obesity) in adolescents high school students. The extension activities were carried out for 2 hours, starting with giving a pre-test questionnaire and ending with giving a post-test according to the topic of the extension, each with 10 questions, with the same types of questions. The pre-test and post-test were used to see the presentation of the increase in knowledge and understanding of the extension participants. This training was attended by 26 participants. From the results of the pre-test and post-test answers given, there is an increase in understanding and knowledge about Diabetes Mellitus and risk factors in adolescents.
IDENTIFICATION IDENTIFICATION OF THE CHEMICAL COMPOUNDS OF CITRUS HYSTRIX ESSENTIAL OIL, CANANGA ORDORATA ESSENTIAL OIL, AND POGOSTEMON CABLIN BENTH ESSENTIAL OIL USING GAS CHROMATOGRAPHY-MASS SPECTROPHOTOMETRY (GC-MS) Yelfi Anwar; Efa Bonita; Andrianopsyah Mas Jaya Putra
BIOEDUKASI Vol 21 No 1 (2023)
Publisher : PROGRAM STUDI PENDIDIKAN BIOLOGI FAKULTAS KEGURUAN DAN ILMU PENDIDIKAN UNIVERSITAS JEMBER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/bioedu.v21i1.38039

Abstract

Essential oils, commonly known as etheric oils (essential oil, volatile oil), are produced by plants and can be obtained from the roots, stems, leaves, and flowers of plants. This study aims to determine the chemical components of kaffir lime (Citrus hystix) essential oil, ylang ylang (Cananga ordorata), and patchouli oil (Pogostemon cablin benth) obtained from farmers and refiners in Lembang, West Java. The composition of this essential oil was analyzed using the gas chromatography–mass spectrometry (GC–MS) method. The results of the analysis of the chemical components of the essential oil constituents of kaffir lime showed that the main components included linalyl acetate (20.59%), D-limonene (17.77%), and linalool (15.19%). In ylang-ylang oil, bioactive compounds such as sesquiterpenes, namely caryophyllene, were found in as much as 14.36%, which has anti-inflammatory, anti-bacterial, and local anesthetic properties. Identification of patchouli oil with its main component, namely patchouli alcohol, at 19.27%.
Identification Chemical Compounds of Cymbopogon nardus (L.) Rendle Essential Oil Using Gas Chromatography and Mass Spectrophotometry (GC-MS) Marisa Tamara Sari; Yelfi Anwar; Andrianopsyah Mas Jaya Putra
BIOEDUKASI Vol 21 No 2 (2023)
Publisher : PROGRAM STUDI PENDIDIKAN BIOLOGI FAKULTAS KEGURUAN DAN ILMU PENDIDIKAN UNIVERSITAS JEMBER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/bioedu.v21i2.39692

Abstract

The fragrant Citronella oil derived from Cymbopogon nardus (L.) Rendle has many benefits, one of which is as an antibacterial. This research aims to identify the chemical compounds present in the essential oil Citronella obtained from a local distillery in Anding Village, Suliki District, Gunung Mas 50 Kota Regency, Province West Sumatra. The essential oil Citronella was identified using Gas Chromatography-Mass Spectrophotometry (GC-MS) at the BRIN (National Research and Innovation Agency) chemistry laboratory in Serpong, South Tangerang, Banten. The results showed that the essential oil Citronella met the requirements of SNI 06-3953-1995, and after being identified with GC-MS, 39 chemical compounds were found, with 3 compounds having high concentrations in the essential oil: Citronellal (24.57%), Citronellol (11.69%), and Geraniol (15.59%).
Formulasi Obat Kumur Minyak Atsiri Sereh Wangi (Cymbopogon nardus (L.) Rendle) dan Uji Aktivitas Antibakteri terhadap Streptococcus mutans Marisa Tamara Sari; Yelfi Anwar; Andrianopsyah Mas Jaya Putra
Bioscientist : Jurnal Ilmiah Biologi Vol 11, No 1 (2023): June
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v11i1.8308

Abstract

Mouthwash is a liquid, aqueous composition that is primarily used to treat oral conditions, as well as maintain oral health. The purpose of this study was to prove the antibacterial efficacy of citronella essential oil against Streptococcus mutans bacteria made in mouthwash formulations. Citronella essential oil was analyzed using GC-MS and then formulated into a mouthwash with concentrations of 1.5%, 3% and 4.5% at cold temperatures (2-8°C) and room temperature (20-25°C).The test results were evaluated, and analyzed using One Way ANOVA and Post Hoc Tukey. The GC-MS results showed that 3 main compounds were detected, namely Citronellol (11.69%), Geraniol (15.59%), and Citronellal (24.57%). The mouthwash formulation did not show any organoleptic change in physical preparation, was homogeneous, had a pH range of 4.91-5.18 at cold temperature and pH 5.02-5.23 at room temperature, had a viscosity consistency that met the standard of 0.8 -1 at cold temperature and room temperature, and no separation was found, such as the presence of precipitate in each treatment. Formula 3 is considered to have medium inhibition compared to formulas 1 and 2 with an average inhibition power at cold temperature formula 6.73 while at room temperature formula 7.35. Briefly, the formulation is stable both at cold temperature (2-8°C) and room temperature (20-25°C) with moderate inhibition at a concentration of 4.5%.