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All Journal PHARMACON Pharmacology and Clinical Pharmacy Research
Erladys M. Rumondor
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Medicine & Pharmacology

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Anti-proliferative Activity of Crotalaria pallida Aiton on MCF-7 Breast Cancer Cells Erladys M. Rumondor; Moelyono Moektiwardoyo; Melisa I. Barliana
Pharmacology and Clinical Pharmacy Research Vol 2, No 3
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (145.873 KB) | DOI: 10.15416/pcpr.v2i3.16218

Abstract

 Crotalaria pallida Aiton (C. pallida Aiton) is empirically used as dietary supplement to treat cancer by the people of North Sulawesi. However, its scientific pharmacology activity has not been explored yet. Therefore, this study was conducted to evaluate anti-proliferative activity of C. pallida Aiton on MCF-7 breast cancer cells. The extraction of leaves and seeds were performed using ethanol, ethyl acetate, n-hexane, and water. Phytochemical screening was then performed to identify secondary metabolites in this extract. Anti-proliferative activity was evaluated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The results indicated that ethyl acetate fraction of C. pallida Aiton has the lowest IC50 (29,67). In conclusion, ethyl acetate fraction of C. pallida Aiton is potential to be developed as anti cancer agent.Keywords: Crotalaria pallida Aiton, WST assay, MCF-7 cell line
UJI AKTIVITAS EKSTRAK ETANOL SPONS Theonella swinhoei TERHADAP PERTUMBUHAN BAKTERI Escherichia coli DAN Staphylococus aureus Kevin R. Mengko; Defny S. Wewengkang; Erladys M. Rumondor
PHARMACON Vol. 11 No. 1 (2022): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.11.2022.39124

Abstract

ABSTRACTSponges are one of the components that compose coral reef which have a potential bioactive substance that has not been utilized. This test attempts to to know the antibacterial compound activity of sponges Theonella swinhoei extracts against the bacterial growth of Escherichia coli and Staphylococcus aureus. Maceration method is used for this extraction using 95% ethanol as solvent. The antibacterial activity is tested using the disk diffusion agar method kirby-bauer. The results against Staphylococcus aureus is 12,99 mm, 12,98 mm and 12,28 mm. Escherichia coli is 11,83 mm, 11,79 mm and 11,53 mm. The results showed that the extract is effective in inhibiting the bacterias and categorized strong against both bacterias. Keywords: Theonella swinhoei, Staphylococcus aureus, Escherichia coli, Extraction, Antibacterial ABSTRAKSpons merupakan satu biota laut penyusun terumbu karang yang mempunyai potensi bioaktif yang belum banyak dimanfaatkan. Penelitian ini bertujuan untuk untuk mengetahui aktivitas antibakteri dari ekstrak spons Theonellala swinhoei terhadap pertumbuhan bakteri Eschercia coli dan Staphylococus aureus. Metode ekstraksi yang digunakan adalah maserasi dengan menggunakan pelarut etanol 95%. Pengujian aktivitas antibakteri menggunakan metode disc diffusion kirby-bauer. Hasil yang didapat dari pengujian aktivitas antibakteri terhadap bakteri Staphyloccous aureus adalah 12,99 mm, 12,98 mm dan 12,28 mm dan Escherichia coli adalah sebesar 11,83 mm, 11,79 mm dan 11,53 mm.  Hasil uji menunjukan bahwa ekstrak tergolong kuat dalam aktivitas antibakteri terhadap bakteri uji. Kata Kunci: Theonella swinhoei, Staphylococcus aureus, Escherichia coli, Ekstraksi, Antibakteri
POTENSI ANTIBAKTERI EKSTRAK DAN FRAKSI DARI ORGANISME LAUT Stylissa carteriTERHADAP PERTUMBUHAN BAKTERI Staphyloccus aureus DAN Escherichia coli Viska Fadila Tompunu; Defny S. Wewengkang; Erladys M. Rumondor
PHARMACON Vol. 11 No. 1 (2022): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.11.2022.39135

Abstract

ABSTRACTSponges are multicellular metazoan animals belonging to the phylum Porifera. Sponges have antibacterial, anticancer and anti-parasitic activity. The purpose of this study was to determine whether Stylissa carteri sponge obtained from the waters of Manado Bay have the potential of antibacterial activity against Staphyloccous aureus and Escherichia coli bacteria. The extraction method used is maceration using 95% ethanol as solvent and the fractionation method used is liquid-liquid fractionation. Testing of antibacterial activity using disk diffusion agar method (kirby-bauer). The results obtained from the antibacterial activity test against Staphylococcus aureus bacteria, the methanol fraction obtained an average yield of 10.21 mm, and the n-hexane fraction obtained an average yield of 6.93 mm. Against Escherichia coli bacteria, the methanol fraction obtained an average yield of 7.96 mm and the n-hexane fraction averaged 8.62 mm, while the ethanol extract and chloroform fraction did not shown antibacterial activity against the two test bacteria. The methanol fraction had strong inhibition against Staphylococcus aureus and moderate inhibition against Escherichia coli, while the n-hexane fraction had moderate inhibition against the two test bacteria.                                                                                               Keywords: Stylissa carteri, antibacterial, Staphylococcous aureus, Escherichia coli.  ABSTRAKSpons merupakan hewan metazoa multiseluler yang tergolong dalam filum porifera. Spons  memiliki aktivitas antibakteri, anti kanker dan anti parasit. Tujuan penelitian ini untuk mengetahui apakah spons Stylissa carteri yang diperoleh dari perairan Teluk Manado memiliki potensi aktivitasi antibakteri terhadap bakteri Staphyloccous aureus dan Escherichia coli. Metode ekstraksi yang digunakan adalah maserasi dengan menggunakan pelarut etanol 95% dan metode fraksinasi yang digunakan yaitu fraksinasi cair-cair. Pengujian aktivitas antibakteri menggunakan metode difusi agar (disc diffusion kirby). Hasil yang didapat dari pengujian aktivitas antibakteri terhadap bakteri Staphyloccous aureus, fraksi metanol mendapatkan hasil rata-rata 10,21 mm, dan pada fraksi n-hexan hasil rata-rata 6,93 mm. Pada bakteri Escherichia coli, fraksi metanol mendapatkan hasil rata-rata 7,96 mm dan pada fraksi n-hexan hasil rata-rata 8,62 mm, sedangkan ekstrak etanol dan fraksi kloroform tidak memiliki aktivitas antibakteri pada kedua bakteri uji. Fraksi metanol memiliki daya hambat kuat terhadap bakteri Staphyloccous aureus dan daya hambat sedang pada bakteri Escherichia coli, sementara fraksi n hexan memiliki daya hambat sedang terhadap kedua bakteri uji. KataKunci:Stylissa carteri, antibakteri, Staphylococcous aureus, Escherichia coli 
Co-Authors Defny S. Wewengkang Kevin R. Mengko Melisa I. Barliana Moelyono Moektiwardoyo Viska Fadila Tompunu