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Patricia Iskandar
Dokter Gigi Spesialis Ortodonti Fakultas Kedokteran Gigi, Universitas Indonesia Jakarta Pusat, Indonesia
Dentistry

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Peran prostaglandin pada pergerakan gigi ortodontik Patricia Iskandar; Nia Ayu Ismaniati
Journal of Dentomaxillofacial Science Vol. 9 No. 2 (2010): Formerly Jurnal Dentofasial ISSN 1412-8926
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15562/jdmfs.v9i2.238

Abstract

Orthodontic tooth movement is a complex process, in which cellular and chemicalchanges occur. When a force is applied onto a tooth, it causes tissue injury,compression of periodontal ligament and bone deformation. These procedures lead tofollowed by certain biochemical reactions at cellular level which results in boneremodeling. Thus a process of signal transduction occurs. In this process, somemessengers are released, including prostaglandin. Prostaglandin is an arachidonicacid metabolite, released when cell membrane is deformed. Prostaglandin,particularly PGE, play a role in bone metabolism and orthodontic tooth movement.Prostaglandin will stimulate the release of second messengers, i.e. cAMP and calciumintracellular. These second messengers will activate osteoclasts. Prostaglandin willalso induce RANKL (receptor activator of nuclear factor κβ ligand) to initiateosteoclasts differentiation. Some researchers proved that application of prostaglandinin orthodontic treatment can accelerate tooth movement.
Co-Authors Nia Ayu Ismaniati