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Ardo Sabir
Department of Conservative Dentistry, Faculty of Dentistry, Hasanuddin University, Makassar, Indonesia
Dentistry

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Indonesian propolis suppressed the expression of COX-2 in inflamed rat dental pulp in direct capping treatment Ardo Sabir
Journal of Dentomaxillofacial Science Vol. 4 No. 2 (2019): (Available online: 1 August 2019)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15562/jdmfs.v4i2.966

Abstract

Objective: The aim of the present study ass to analysis the expression COX-2 on inflamed rat dental pulp after capped with propolis. Material and Methods: Propolis was obtained from South Sulawesi, Indonesia. Flavonoid and non-flavonoid were purified from an ethanolic extract of propolis (EEP). Eighty male Sprague Dawley rats were divided randomly into 5 groups, each group consisting of 16 rats. Group I as a negative control, rats were left without any treatment. A Class I cavity was prepared on the occlusal surface of permanent maxillary right first molar. Dental pulp was exposed and allowed in oral environment for 1 hour, then capping with EEP (group II), flavonoid propolis (group III), non-flavonoid propolis (group IV), or calcium hydroxide (Ca(OH)2) (group V). All cavities were filled with glass ionomer cement. The animals were sacrificed at 6 hours, 2, 4 or 7 days after treatment, biopsy samples were obtained, processed for immunostaining of COX-2 and viewed under light microscope. Data was statistically analyzed using Friedman and Kruskal-Wallis tests with significant level P<0.05. Results: Except in group I, COX-2 expression was decreased in all treatment group with the longer of observation time periods. In group II and group V, COX-2 expression was weaker than group III and IV at all periods time. However, there was no statistically significant differences of COX-2 expression among groups for each time period. Conclusions: The present study suggests that EEP and Ca(OH)2 were stronger than other materials test to suppressed COX-2 expression on inflamed rat dental pulp.
Does propolis can relief toothache??? Ardo Sabir
Journal of Dentomaxillofacial Science Vol. 4 No. 2 (2019): (Available online: 1 August 2019)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (723.674 KB) | DOI: 10.15562/jdmfs.v4i2.967

Abstract

Objective: The aim of this literature review is to highlights the role and mechanisms of propolis at the molecular level in relief toothache caused by dental pulp inflammation.Methods: This review complied data from our study as well as from other researchers, focusing on molecular mechanism of inflammation, dental pain mechanism caused by inflammation and the role of propolis on inflammatory process.Results: Both in vitro and in vivo or even clinical research revealed thatpropolis has anti-inflammatory. Propolis could suppresses cyclooxygenase(COX) and lipoxygenase (LOX) enzymes during inflammation. COX-2 is mainly inhibited by flavonoid which suppresses prostaglandin endoperoxide synthase at high concentration depending on the hydrophilicity and structure whereas LOX is mainly inhibited by quercetin component of propolis. The major component of propolis is the caffeic acid (3.4-dihydroxycinnamic acid) phenethyl ester (CAPE). It has anti-inflammatory by inhibits LOX and COX enzymes that are involved in the AA metabolism pathways.Conclusion: It could be that propolis effective to relief toothache (odontalgia).
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