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All Journal Molecular and Cellular Biomedical Sciences (MCBS)
Rina Triana
Magister Program of Clinical Pharmacy, Faculty of Pharmacy, Padjajaran University, Bandung
Biochemistry, Genetics & Molecular Biology Dentistry Immunology & microbiology Medicine & Pharmacology Neuroscience

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Ischemic Stroke: New Neuron Recovery Approach with Mesenchymal and Neural Stem Cells Angliana Chouw; Rina Triana; Nurrani Mustika Dewi; Siska Darmayanti; Miftakh Nur Rahman; Ardian Susanto; Bayu Winata Putera; Cynthia Retna Sartika
Molecular and Cellular Biomedical Sciences Vol 2, No 2 (2018)
Publisher : Cell and BioPharmaceutical Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (877.297 KB) | DOI: 10.21705/mcbs.v2i2.28

Abstract

Stroke is a leading cause of death and long-term disability. This due to the ischemic event that cause by embolism of blockage blood flow. Thrombolytic agent plasminogen activator (tPA) is the only treatment approved by FDA. However, the used of tPA is limited to the short time window period. Neural stem cells (NSCs) show the potential to repair neuronal damage naturally after stroke. However, isolating NSCs is a challenging process due to the limitations of the method and its invasiveness. Some studies that had used mesenchymal stem cell (MSCs) as the main source of stem cell for therapy show that MSCs have the potency to differentiate into NSCs. in vitro, a differentiation process from MSC to NSC has been developed by combining the supplement or growth factor needed in the culture media.Keywords: stem cells, neuron stem cell, mesenchymal stem cell, stroke, trans-differentiation
Co-Authors Angliana Chouw Ardian Susanto Bayu Winata Putera Cynthia Retna Sartika Miftakh Nur Rahman Nurrani Mustika Dewi Siska Darmayanti