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Rosalina Wisastra
Bioorganic, Department of Chemistry, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung
Mathematics

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Synthesis of Isothiazolone and 5-Chloroisothiazolone Derivatives Through Simple Amidation and Cyclization Processes Rosalina Wisastra; Frank J. Dekker; Megawati Santoso
Jurnal Matematika & Sains Vol 16, No 2 (2011)
Publisher : Institut Teknologi Bandung

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Abstract

Several methyl alkanoate substituted isothiazolones and 5-chloroisothiazolones were synthesized using a simple amidation process of 3,3’-dipropionic acid and chlorination during 3,3’-dithiobispropanamide cyclization process, respectively. The results showed that 5-chloroisothiazolones were produced in a good yield (40-70%), whereas the isothiazolones are produced in moderate yield (±20%). Keywords: Isothiazolone, 5-chloroisothiazolone, Organic synthesis, 3,3’-dithiopropionic acid. Sintesa Derivatif Isothiazolon dan 5-Kloroisothiazolon melalui Proses Amidasi dan Siklisasi Sederhana Abstrak Berbagai senyawa turunan dari isothiazolon tersubsitusi oleh metil alkanoat dan 5-kloroisothiazolon disintesis masing-masing melalui proses amidasi sederhana pada senyawa 3,3’-asam dipropionat dan klorinasi saat terjadinya siklisasi 3,3’-dithiobispropanamida. Dalam penelitian ini, 5-kloroisothiazolon tersubsitusi oleh metil alkanoat dapat dihasilkan dengan yield yang memadai (40-70%), sedangkan isothiazolon dapat dihasilkan dengan yield 20%. Kata kunci: Isothiazolon, 5-kloroisothiazolon, Sintesis organik, Asam 3,3’-dithiopropionat
Co-Authors Frank J. Dekker Megawati Santoso