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All Journal Jurnal MIPA PHARMACON CHEMISTRY PROGRESS
Max R. J. Runtuwene
Jurusan Kimia FMIPA Universitas Sam Ratulangi Manado
Biochemistry, Genetics & Molecular Biology Chemistry Mathematics Medicine & Pharmacology Physics

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ANALISIS FITOKIMIA TUMBUHAN OBAT DI KABUPATEN MINAHASA UTARA Sangi, Meiske; Runtuwene, Max R. J.; Simbala, Henry E. I.; Makang, Veronica M. A.
CHEMISTRY PROGRESS Vol 1, No 1 (2008)
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/cp.1.1.2008.26

Abstract

A research has been done to analyze the phytochemical of medicine plant used by North Minahasa society. The research done qualitatively to know the present of alkaloid component, flavonoid, triterpenoid, steroid, saponin, and tannin. Analyzes of alkaloid component using Mayer, Dragendorff and Wagner reagents showed presipitate when react with alkaloid. Mayer reagent showed white presipitate, Dragendorff reagent showed red-orange presipitate and Wagner reagen showed brown presipitate. In flavonoid analysis, positive result indicated with red solution. Saponim analysis indicated with a stable foam. Tannins analysis indicated with green and blue-black solution and triterpenoid analysis indicated with red-orange or purple solution. Although the steroida analysis indicated with blue solution. The result show that 46 samples from 46 spesies of medicine plant that had been analyzed are 97,83% positive containing alkaloid component; 13,04% containing triterpenoid; 28,26% containing steroid; 47,83% containing flavonoid; 63,04% containing saponin and 63,44% containing tannin.
NANO KITOSAN EKSTRAK TONGKOL JAGUNG MANADO KUNING (ZEA MAYS L.) DAN AKTIVITAS ANTIOKSIDANNYA Kabalmay, Julista Alfa; Suryanto, Edi; Runtuwene, Max R. J.
CHEMISTRY PROGRESS Vol 12, No 1 (2019)
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/cp.12.1.2019.27916

Abstract

ABSTRAK Tujuan dari penelitian ini untuk mengetahui potensi antioksidan dari nanopartikel kitosan ekstrak tongkol jagung Manado kuning. Penelitian ini terdiri dari 2 tahap yaitu ekstraksi dan pembuatan nanopartikel kitosan. Parameter yang digunakan adalah total senyawa fenolik dan kemampuan mereduksi, ukuran partikel, indeks polidispersitas, dan morfologi permukaan nanopartikel kitosan ekstrak tongkol jagung Manado kuning. Pembuatan nanopartikel kitosan menggunakan metode gelasi ionik. Hasil penelitian menunjunkkan partikel serbuk tongkol jagung 75 µm  memiliki rendemen dan kandungan total fenolik yang lebih tinggi dibanding  ukuran 150 µm. Formula F1 nanopartikel kitosan ekstrak tongkol jagung memiliki ukuran partikel  yang lebih kecil (318,7 nm) daripada F2 (333,8 nm), dan F3  (339,9 nm).  Hasil pengamatan morfologi permukaan nanopartikel kitosan adalah berbentuk seperti gumpalan yang masih berukuran mikrometer dan bentuk bulat tidak sempurna. Hasil pengujian aktivitas antioksidan bahwa formulasi F1 memiliki aktivitas yang terbaik dibandingkan dengan F0, F2 dan F3. ABSTRACT The objective of this study was to determine the antioxidant potential of chitosan nanoparticles from corncob extracts of Manado yellow corn. The study was consist of two stages: extraction and synthesis of chitosan nanoparticles. The parameters evaluated were total phenolic content (TPC), reducing power, particle size, index of polydispersity, and surface morphology of chitosan nanoparticles from Manado yellow corncob extract. Synthesis of chitosan nanoparticles was carried out by using ionic gelation method. The result showed that corncob powder with particle size 75 ?m had higher recovery yield and higher total phenolic content (150 ?m) than 150 ?m. Formula F1 chitosan nanoparticles extract of corncob had smaller particle size (318.7 nm) compared to F2 (333.8 nm) and F3 (339.9 nm). Surface morphology observation revealed that the shape of chitosan nanoparticles were like lumps with imperfect round shape within micrometer-size. Antioxidant activity assay showed that the F1 had the highest antioxidant activity compared to F0, F2 and F3. 
AKTIVITAS ANTIOKSIDAN FRAKSI ETIL ASETAT DAN FRAKSI HEKSANA DAUN SOYOGIK (Saurauia bracteosa DC) TERHADAP OKSIDASI ASAM LINOLEAT Runtuwene, Max R. J.; Kamu, Vanda S; Rotty, Marsella
CHEMISTRY PROGRESS Vol 14, No 2 (2021)
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/cp.14.2.2021.37559

Abstract

Soyogik (Saurauia bracteosa DC) merupakan tanaman obat yang berasal dari Minahasa Tenggara, Provinsi Sulawesi Utara. Penelitian ini bertujuan untuk menentukan potensi aktivitas antioksidan ekstrak dan fraksi pelarut dari daun soyogik. Ekstraksi dilakukan dengan maserasi menggunakan metanol dan fraksinasi dengan n-heksana dan etil asetat. Kandungan total fenolik ekstrak dan fraksi diukur menggunakan uji Folin-Ciocalteu sedangkan aktivitas antioksidan dievaluasi dengan penghambatan oksidasi asam linoleat dengan metode Ferric Thiocyanate (FTC) dan penghambatan malonaldehid (MDA) dengan metode Thiobarbituric Acid Reactive Substance (TBARS). Hasil penelitian menunjukkan bahwa kandungan fenolik yang dinyatakan dalam ekuivalen asam galat dari ekstrak dan fraksi berkisar antara 50,83-99,67 g/mL. Fraksi etil asetat memiliki kandungan fenolik yang lebih tinggi dibandingkan fraksi heksana dan ekstrak metanol. Hasil penelitian ini juga menunjukkan bahwa fraksi etil asetat, n-heksana, dan α-tokoferol memiliki penghambatan peroksida masing-masing sebesar 50,21, 44,26, dan 46,96% dan penghambatan malonaldehid masing-masing 91,03, 88,81, dan 89,48%. Kemampuan hambat peroksida dan malonaldehid menunjukkan bahwa fraksi etil asetat memiliki aktivitas antioksidan yang lebih tinggi dibandingkan fraksi n-heksana dan a-tokoferol sebagai kontrol positif.ABSTRACT Soyogik (Saurauia bracteosa DC) is a medicinal plant originating from Southeast Minahasa, North Sulawesi Province. The objective of study was to determine the potential antioxidant activity of the extract and the solvent fraction of soyogik leaves. Extraction was carried out by maceration using methanol and fractionation with n-hexane and ethyl acetate. The total phenolic contents of extract and fractions were measured using a Folin-Ciocalteu assay while the antioxidant activities was evaluated by the inhibition of linoleic acid oxidation with the Ferric Thiocyanate (FTC) and measuring the malonaldehyde (MDA) inhibition with the Thiobarbituric Acid Reactive Substance (TBARS) methods. The results showed that phenolic content expressed in gallat acid equivalent of extract and fractions ranged from 50.83-99.67 µg/mL. The ethyl acetate fraction has higher phenolic content than hexane fraction and methanol extract. The results showed also that the ethyl acetate, n-hexane fractions and a-tocopherol had peroxide inhibition were 50.21, 44.26, and 46.96%, respectively and the inhibition of malonaldehyde were 91.03, 88.81, and 89.48% respectively. The inhibitory ability of peroxides and malonaldehyde showed that the ethyl acetate fraction had higher antioxidant activity than the n-hexane and a-tocopherol fractions as positive controls.
Co-Authors Arter Dein Muaja Dina E. B. Rompas, Dina E. B. Edi Suryanto Erling Pasaraeng Filbert . Gerry Sumihe Griffin A. D. Rambi, Griffin A. D. Harry S. J. Koleangan Henry E. I. Simbala Jemmy Abidjulu Jhon Smith Wongkar, Jhon Smith Johnly A. Rorong Kabalmay, Julista Alfa Lakoro, Julia Elsa Lidya I. Momuat Meiske Sangi Paulina yamlean Rotty, Marsella Triyono Mojo, Triyono Vanda S Kamu Vanda S. Kamu Veronica M. A. Makang Yusuf R. Fattah