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All Journal JURNAL GIZI INDONESIA Diponegoro International Medical Journal (DIMJ) Archives of The Medicine and Case Reports Journal of Sustainability Perspectives
Galuh Hardaningsih
Department Of Pediatrics, Faculty Of Medicine, Diponegoro University
Education Engineering Environmental Science Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health

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The Association between Serum Malondialdehyde and Nitric Oxide Level of Children Living In Area of Chronic Pesticide Exposure Astra Parahita; Galuh Hardaningsih; Anindita Soetadji
Diponegoro International Medical Journal Vol 1, No 1 (2020): July
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v1i1.7897

Abstract

Background: Chronic exposure of organophosphate pesticides is an oxidative stress that causes liver and aortic damage. Malondialdehyde (MDA) is a biological marker of oxidative damage to cell lipids membrane. The liver produces insulin growth factor-1 (IGF-1) which stimulates the enzyme nitric oxide synthase (eNOS) to produce vascular nitric oxide (NO). Children who are living in those area may be exposed to pesticide chronically. Objective: The study aims is to determine the relationship between serum MDA and NO level of children living in an area of chronic pesticide exposure.Method: Cross sectional study was conducted to 50 children aged between 8 – 10 years in agriculture areas of Brebes. Serum MDA and NO level was measured at the same time using ELISA method, data were shown on numerical scale. Statistical analysisby Pearson correlation.Result: Fifty children met the criteria, consisting of 30 males (60%) and 20 females (40%). The mean of serum MDA level in males, females, and total subjects were normal 6.03 (3.86) µg/ mL, 5.18 (2.11) µg/ mL, and 5.69 (2.60) µg/ mL, respectively. The mean of serum NO level in males, females, and total subjects were increased 79.42 (50.78) µmol/ L, 68.11 (50.81) µmol/ L, and 74.90 (50.58) µmol/ L, respectively. There was no association between serum MDA and NO level found.Conclusion: Serum NO level of children living in an area of chronic pesticide exposure was higher than normal value. However, there was no association between serum MDA and NO level found.
Risk factor of growth faltering in infants aged 2-12 months Rina Pratiwi; Adriyan Pramono; Galuh Hardaningsih
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 10, No 1 (2021): December
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jgi.10.1.72-79

Abstract

Background: Growth faltering is a condition of growth disturbance that marked by slower growth velocity compared with previous growth chart. Growth faltering can cause effects in immune response, cognitive, & physical and psychomotor disturbance, behavioral disorder, learning problems, higher risk of infection and mortality.Objectives: To analyze risk factor of growth faltering in infant aged 2-12 months.Materials and Methods: A case control study was conducted in Public Health Center in Semarang city. Subject were infants aged 2 until 12 months with growth faltering. Variables were divided to exclusive breastfeeding, mother’s education, mother’s employment, social economic status, infection, mother’s nutrition and gestational age. Anthropometric and questionnaire data were obtained and analyzed among 116 infants. Statistic test used Chi square and multivariate analysis.Results: Chi-square analysis showed that breastfeeding (p=0.016) and gender (p=0.04) had a significant relationship with growth faltering in infant 2-12 months. Under standard parent’s income (p=0.809), Acute Respiratory Tract Infection (ARTI) (p=0.377), diarrhea (p=0.243), mother’s nutrition (p=1.00), gestational age (p=0.77), low mother’s education (p=0.83) and working mother (p=0.26) didn’t have a significant relationship with growth faltering in infant aged 2-12 months. Multivariate analysis showed that gender (p=0.035) and breastfeeding (p=0.019) were the most influencing variable to growth faltering. In 2-6 group, breastfeeding pattern had significant relationship with growth faltering (p=0.77)Conclusions: Breastfeeding and gender were risk factors of growth faltering in infant aged 2-12 months. Further research needed on how to prevent growth faltering in first 1000 days of life so it may avoid stunting in later life.
The Relationship between Vitamin D Levels and Muscle Mass in Obese Children Hefira Rosadiani; Wistiani; Galuh Hardaningsih
Archives of The Medicine and Case Reports Vol. 4 No. 1 (2023): Archives of The Medicine and Case Reports
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/amcr.v4i1.272

Abstract

Obesity can result in the secretion of proinflammatory mediators, which can result in vitamin D deficiency and decreased muscle mass. Good muscle mass is necessary for a good quality of life in obese children. This study aimed to determine the relationship between vitamin D levels and muscle mass in obese children. The average muscle mass in obese children is 15.04 kg. As many as 24.4% of children have normal muscle mass levels, while 75.6% of obese children have low muscle mass. This study is an analytic observational study with a cross-sectional approach. A total of 86 research subjects participated in this study. Measurement of muscle mass and vitamin D levels was carried out in this study. Data analysis was performed using SPSS version 20 using univariate and bivariate methods. The average vitamin D level was 26.65 ng/mL. As many as 69.8% of obese children had normal vitamin D levels, while 30.2% had low levels of vitamin D. In conclusion, there is no relationship between vitamin D levels and muscle mass in obese children.
The Association of Food Insecurity and Chronic Diarrhea on the Prevalence of Stunting in Children under 2-5 Years of Age Agnia Marisa; Vivilia Niken Hastuti; Nina Resti; Galuh Hardaningsih; Martha Ardiaria; Denny Nugroho Sugianto; Diana Nur Afifah
Journal of Sustainability Perspectives Vol 5, No 1 (2025)
Publisher : Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jsp.2025.28638

Abstract

Stunting is associated with food insecurity and diarrheal infections. Age under five years is a golden age, which is very important for optimizing growth and development in the future. This study aimed to investigate the association between food insecurity and diarrhea and the prevalence of stunting in toddlers aged 2-5 years. Analytical observations using cross-sectional design. The study sample comprised 140 children aged 2-5 years. The sample was selected by simple random sampling. Data analysis was performed using univariate, chi-squared, Kruskal-Wallis, and multivariate tests. A total of 18.6% of the toddlers were stunted, 66 families were food insecure, and 31 toddlers had diarrhea. There was a relationship between chronic diarrhea and short nutritional status (p<0.001), and there was a significant relationship between food insecurity and the incidence of stunting (p=0.001). Results of the multivariate analysis using logistic regression. The final modal formula was log p (stunting) = -2.549 + 1.808 (parental income < minimum wage) + 6.098 (history of diarrhea) + 1.396 (food insecurity). Diarrhea is the dominant factor that most influences the incidence of stunting.
Co-Authors Adriyan Pramono Agnia Marisa Anindita Soetadji Astra Parahita Denny Nugroho Sugianto Diana Nur Afifah Hefira Rosadiani Martha Ardiaria Nina Resti Rina Pratiwi Vivilia Niken Hastuti Wistiani