Novina Rahmawati
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Faktor risiko yang mempengaruhi disfungsi tuba Eustachius pada penderita rinitis alergi persisten Novina Rahmawati; Suprihati Suprihati; Muyassaroh Muyassaroh
Oto Rhino Laryngologica Indonesiana Vol 41, No 2 (2011): Volume 41, No. 2 July - December 2011
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (338.232 KB) | DOI: 10.32637/orli.v41i2.51

Abstract

Background: Persistent allergic rhinitis (AR) can lead to Eustachian tuba dysfunction. It could beinfluenced by many factors. Purpose: To prove that AR’s degree, duration, presence of chronic tonsillitisand the use of air conditioner are the risk factors of the Eustachean tube dysfunction in patients withpersistent allergic rhinitis. Method: A cross-sectional study was conducted on patients between 11-54years age who came with persistent AR. Tubal dysfunction was detected by tympanometric examination (MEP negative <-25 mmH2O). The data analysis was analyzed using Chi square test and prevalence ratio. Results: There were 68 subjects. The largest age group was 23-34 years old with mean age is 27.8years. Twenty-six patients (32,8%) with persistent AR had tubal dysfunction. Chi square test for persistentAR’s degree, duration of AR and presence of chronic tonsillitis had no significant relationship with tubaldysfunction. The use of AC was significantly correlated with tubal dysfunction (p>0.05). Multivariatelogistic regression analysis found that it became a risk factor for tubal dysfunction p= 0.019, RP=5.446, CI 95%= 1.321- 22.575. Conclusion: The use of AC becomes a risk factor for tubal dysfunctionin patients with persistent allergic rhinitis. Keywords: persistent allergic rhinitis, Eustachean tube dysfunction, tympanometry Abstrak :  Latar belakang: Rinitis alergi (RA) persisten dapat menimbulkan disfungsi tuba Eustachius. Disfungsituba dapat dipengaruhi oleh beberapa faktor. Tujuan: Membuktikan bahwa derajat RA, lama sakit RA,keberadaan tonsiltis kronik dan pemakaian air conditioner (AC) merupakan faktor risiko terjadinyadisfungsi tuba pada penderita rinitis alergi persisten. Metode: Penelitian dengan metode potong-lintangpada RA persisten usia 11-54 tahun. Disfungsi tuba ditentukan dengan pemeriksaan timpanometri (MEPnegatif/<-25 mmH2O). Analisis hasil dengan uji Chi square dan rasio prevalensi. Hasil: Didapatkan68sampel. Usia terbanyak 23-34 tahun, rerata usia 27,8 tahun. Penderita RA persisten dengan disfungsituba 26 (38,2%). Uji Chi square didapatkan derajat RA persisten, lama sakit dan keberadaan tonsilitiskronik tidak mempengaruhi disfungsi tuba (p>0,05). Analisis regresi logistik multivariate didapatkanpemakaian AC secara independen mempunyai risiko terjadinya disfungsi tuba p=0,019, RP=5,446, CI95%= 1,321-22,575. Kesimpulan: Pemakaian AC merupakan faktor risiko terjadinya disfungsi tubapada penderita rinitis alergi persisten. Kata kunci: rinitis alergi persisten, disfungsi tuba, timpanometri
Effectiveness of ethanol extract of kirinyuh leaf (Chromolaena odorata L) on the increase the fibroblasts and angiogenesis in nose mucosa of rabbit (lepus curpaneums) Teuku Husni TR; Novina RAHMAWATI; Irnawati IRNAWATİ
Journal of Syiah Kuala Dentistry Society Vol 7, No 2 (2022): December 2022
Publisher : Dentistry Faculty

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jds.v7i2.30231

Abstract

Wounds are the loss or damage to a part of the body's tissue that disrupts the tissue's continuity.Kirinyuh plants have been used as a traditional wound treatment in various cultures worldwide. Purpose: To provethe effectiveness of topical ethanol extract of kirinyuh leaf ointment on increasing angiogenesis and fibroblasts inhealing rabbit nasal mucosal incisions. Methods: This research is an experimental study with a posttest-only controlgroup design. The research subjects consisted of 25 rabbits divided into five groups; one positive control group, onenegative control group, and three treatment groups. The positive control group was given betadine ointment, thenegative control group was made by incision of the nasal mucosa, and the three treatment groups were given 5%,10%, and 15% concentrations of kirinyuh leaf ethanol extract ointment. Results: The results showed thatadministering kirinyuh leaf ethanol extract ointment with concentrations of 5%, 10%, and 15% could improve thehealing of rabbit nasal mucosal incisions (Lepus Curpaneums), which were characterized by an increase in thenumber of fibroblasts and angiogenesis. In general, the increase in fibroblast cells between the concentrations of theethanol extract of kirinyuh leaf ointment was significantly different (p0.05) with a negative correlation (r= -0.538).Meanwhile, there was no significant difference in the amount of angiogenesis between concentrations (p0.05) witha positive relationship (r=0.099).Conclusion: the ethanol extract of kirinyuh leaf ointment applied topically improvesthe healing of rabbit nasal mucosal incisions KEYWORDS: ethanol extract of kirinyuh leaf ointment, wound healing, fibroblast, angiogenesis