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Agus Triyono
Balai Besar Penelitian dan Pengembangan Tanaman Obat dan Obat Tradisional Tawangmangu
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

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Studi Klinik Khasiat dan Keamanan Sediaan Tablet Ekstrak Dibanding Rebusan Ramuan Hiperurisemia Agus Triyono; Widhi Astana; Danang Ardianto; Fajar Novianto
JURNAL ILMU KEFARMASIAN INDONESIA Vol 19 No 1 (2021): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v19i1.739

Abstract

Hyperuricemia is a metabolic disorder that is often found in the community, and requires long-termtreatment. To determine the effi cacy and safety of the hyperuricemia herbs, clinical studies have been carried out on the effi cacy and safety of tablet preparations compared to boiled of the hyperuricemia herbs. The clinical study was conducted with an open label research design, randomized clinical study and parallel design. The study involved 55 subjects who had met the inclusion and exclusion criteria. Subjects were randomized and divided into groups of tablets or boiled with intervention for 28 days. The tablet group took tablets with a dose of 3x2 tablets per day and the boiled group drank infusion with a dose of 3 times a glass per day. Blood uric acid was examined at D0, D14 and D28. SGOT, SGPT, urea, and creatinine were examined at D0 and D28. The tablet reduced uric acid (7.74 mg/dL to 6.53 mg/dL) and the boiled reduced uric acid (7.93 mg/dL to 7.09 mg/dL). The administration of tablet preparations eliminates the clinical symptoms of swollen/pain of leg, swollen/pain of hand, stiff ness, pain and other symptoms at the deff erent time than boiled administration. The administration of both preparations for 28 days in the subjects did not increase the value of SGOT, SGPT, urea and creatinine and no symptoms of serious side eff ects were found.
Uji Klinik Khasiat Sediaan Rebusan Ramuan Jamu Hipertensi Dibanding Seduhan Jamu Hipertensi Agus Triyono; Peristiwan Ridha; Danang Ardianto
JURNAL ILMU KEFARMASIAN INDONESIA Vol 16 No 1 (2018): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (300.358 KB) | DOI: 10.35814/jifi.v16i1.425

Abstract

To search for scientific evidence the efficacy of herbal medicine, has conducted clinical trial the efficacy of hypertension herbs compared with hydrochlorotiazide. Efficacy of clinical trials were conducted with the design open-label, randomized clinical trials and parallel design. It was involving 80 subjects who have met the inclusion and exclusion criteria. Subjects randomized study that is divided into two groups, a herbs group and hydrochlorotiazide group. Subjects performed once a week to check the complaint history, the development of clinical symptoms, the possibility of side effects and diagnostic physical examination. Assessment score of quality of life by questionnaires Short Form 36 (SF-36) every four weeks. Results showed that administration of herbal medicine for 56 days hypertension, lower blood pressure (systolic and diastolikic) is equivalent to hydrochlorotiazide (HCT). Lowering blood pressure to normal (normotensive) 62.7% of the subjects. Eliminating the clinical symptoms of hypertension (dizziness / headache, stiff neck / whiny and myalgia) herbs group subjects at almost the same time with the hidrochlorthiazide group. Raising the quality of life scores (SF-36) subjects herbs group equivalent to the increase in quality of life scores (SF-36) hydrochlorotiazide group.
UJI KLINIK EFEK FORMULA JAMU PENURUN KOLESTEROL DARAH TERHADAP FUNGSI HATI Agus Triyono; Peristiwan R. Widhi Astana
JURNAL FARMASI GALENIKA Vol 4 No Edisi Khus (2017): Jurnal Farmasi Galenika Volume 4 Edisi Khusus SemNas Tanaman Obat Indone
Publisher : Universitas Bhakti Kencana

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Abstract

Hiperkolesterolemia merupakan penyakit degeneratif yang sering memerlukan pengobatan seumur hidup. Hiperkolesterolemia sebagai faktor resiko aterosklerosis yang bisa menyebabkan kematian. Telah dilakukan penelitian efek formula jamu penurun kolesterol darah terhadap fungsi hati (SGOT dan SGPT). Uji klinik dilakukan dengan desain penelitian pre-post test design pada 85 subjek penelitian laki laki dan perempuan usia 25 - 55 tahun. Subjek penelitian minum formula jamu selama enam minggu dengan kontrol seminggu sekali. Dilakukan observasi kinik serta pemeriksaan SGOT dan SGPT pada awal penelitian, hari ke-21 dan hari ke-42. Hasil pemeriksaan SGOT dan SGPT dianalisis dengan uji t berpasangan. Hasil uji t berpasangan sebelum perlakuan dibanding sesudah perlakuan 21 hari untuk kadar SGOT nilai p 0.313 dan kadar SGPT nilai p 0.286. Hasil uji t berpasangan sebelum perlakuan dibanding sesudah perlakuan 42 hari untuk kadar SGOT nilai p 0.204 dan kadar SGPT nilai p 0.280. Tidak ada perbedaan bermakna (p>0.05) kadar SGOT dan SGPT sebelum perlakuan dibanding setelah perlakuan 21 hari dan 42 hari. Jadi disimpulkan bahwa penggunaan formula jamu penurun kolesterol darah selama 42 hari tidak mengganggu fungsi hati.
GAMBARAN PROFIL LIPID PADA PASIEN HIPERTENSI DI KLINIK SAINTIFIKASI JAMU HORTUS MEDICUS TAWANGMANGU Peristiwan R. Widhi Astana; Agus Triyono
JURNAL FARMASI GALENIKA Vol 4 No Edisi Khus (2017): Jurnal Farmasi Galenika Volume 4 Edisi Khusus SemNas Tanaman Obat Indone
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Diagnosis penyakit yang sering dijumpai pada fasilitas pelayanan kesehatan adalah hipertensi. Faktor-faktor penyebab hipertensi sangat beragam. Salah satu di antaranya adalah gangguan profil lipid. Profil lipid dapat memicu terjadinya hipertensi melalui berbagai mekanisme, baik secara langsung atau tidak langsung. Penelitian ini bertujuan untuk meneliti tentang gambaran profil lipid pada pasien dengan diagnosis hipertensi. Penelitian ini menggunakan data sekunder berupa rekam medis pada klinik Saintifikasi Jamu Hortus Medicus Tawangmangu periode Januari – Desember 2013. Metode penelitian yang di gunakan adalah metode yang bersifat deskriptif. Data rekam medis yang diamati adalah data pasien hipertensi yang datang ke klinik hortus medicus dan melakukan pemeriksaan profil lipid. Parameter yang diamati meliputi kolesterol total, kolesterol HDL (High Density Lipoprotein), kolesterol LDL (Low Density Lipoprotein), dan trigliserida. Hasil penelitian menunjukan kadar kolesterol total normal sebanyak 47,6% dengan kadar rata-rata 158,4 mg/dl, kadar kolesterol abnormal sebanyak 52,4% dengan kadar rata-rata 247,2 mg/dl. Kadar kolesterol HDL normal sebanyak 75% dengan kadar rata-rata 53,8 mg/dl, kadar kolesterol HDL abnormal sebanyak 25% dengan kadar rata-rata 34,5 mg/dl. Kadar kolesterol LDL normal sebanyak 54,3% dengan kadar rata-rata 92,4 mg/dl, kadar kolesterol LDL abnormal sebanyak 45,7% dengan kadar rata-rata 152,1 mg/dl. Sedangkan kadar trigliserida normal sebanyak 61,7% dengan kadar rata-rata 112,3 mg/dl, kadar trigliserida abnormal sebanyak 38,3% dengan kadar rata-rata 271,6 mg/dl.
Co-Authors Danang Ardianto Danang Ardianto Fajar Novianto Peristiwan R. Widhi Astana Peristiwan Ridha Widhi Astana