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ERIZAL ERIZAL
PUSAT APLIKASI TEKNOLOGI ISOTOP dan RADIASI PATIR-BATAN
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

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Sintesis Hidrogel Superabsorben Polietilen Oksida-Alginat dengan Teknik Radiasi Gamma dan Karakterisasinya ERIZAL ERIZAL; I WAYAN REDJA
JURNAL ILMU KEFARMASIAN INDONESIA Vol 8 No 1 (2010): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Abstract: In order to develop the applications of radiation for biomaterial preparation, a non-toxic superabsorbent has been synthesized. A series of superbasorbent hydrogel were prepared from aqueous solution containing 5% polyethylene oxide (PEO) with different concentration of alginate (0.5-2.0%) were irradiated at the doses of 20, 30, and 40 kGy by gamma radiation.The gel fraction, swelling kinetics and the equilibrium degree of swelling (EDS) of the hydrogels were studied, It was found that the incorporation of even 2% alginate (sodium salt) increased the EDS of the hydrogels from 20g/g to 320 g/ g. At a dose of 20 kGy, PEO-alginat hydrogels with high gel fraction ( ̴ 8O%) and very high EDS ( ̴ 320 g/g) were obtained. The hydrogels were also found to be sensitive to the ionic solution of NaCl. The PEO-alginate hydrogels could be considered as candidate biomaterials in health care.
Sintesis Hidrogel Poli(N-Vinil-2-Pirolidon-Asam Tartrat) secara Iradiasi Gamma dan Karakterisasinya SWASONO R. TAMAT; ERIZAL ERIZAL; CHAIRIL GUNAWAN
JURNAL ILMU KEFARMASIAN INDONESIA Vol 6 No 1 (2008): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Synthesis of poly(N-vinyl pyrolidone-g-tartaric acid) hydrogel using gamma irradiation had been carried out in two steps. First, irradiation of various concentrations of N-vinyl pyrolidone (NVP) byvarious irradiation doses. The yield of this process was determined by a gravimetric method. Hydrogel with the highest yield was selected for the second step: immersion in various concentrations of tartaric acid (TA) solution followed by irradiation. The yield (grafting percentage) was indirectly determined by a titrimetric method. All hydrogels were tested for their swelling ability (%) in solution of Various pH. The results showed that both NVP concentration and irradiation dose, and also interaction of the two, influenced the yield (gel fraction). The highest gel fraction (99.52%) was obtained from 70% NVP and 40 kGy dose. The result also showed that both TA concentration and irradiation dose, as well asinteraction of the two, influenced the grafting percentage. The highest grafting percentage (42.03%) was obtained by 0.8% TA and 40 kGy dose; while this hydrogel swelled 44.41 times in a pH 8 solution and swelled 42.2 times in a saline solution. The swelling capacity was slightly higher than the SNI 16- 6363-2000 requirement for sanitary napkins, however, lower than the ISO 17190-5-2001 requirement for baby napkins.
Co-Authors CHAIRIL GUNAWAN I WAYAN REDJA SWASONO R. TAMAT